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Magnetic Resonance Myocardial Feature Tracking in Transfusion-Dependent Myelodysplastic Syndrome
Marta Alonso-Fernandez-Gatta,Ana Martin-Garcia,Maria Diez-Campelo,Agustin C. Martin-Garcia,Manuel Barreiro-Pérez,Félix Lopez-Cadenas,Elena Diaz-Pelaez,Pedro L. Sanchez 한국심초음파학회 2021 Journal of Cardiovascular Imaging (J Cardiovasc Im Vol.29 No.4
BACKGROUND: Myocardial deformation with echocardiography allows early detection of systolic dysfunction and is related to myocardial iron overload (MIO) determined by T2* in hereditary anemias under transfusion support. Our aim was to analyze the diagnostic and prognostic usefulness of magnetic resonance feature tracking (MR-FT) myocardial strain in low-risk myelodysplastic syndromes (LR-MDS) patients. METHODS: Prospective study in transfusion-dependent LR-MDS patients and healthy controls who underwent a cardiac MR-FT. We analyzed the relationships between strain MR-FT and iron overload parameters and its prognostic impact in cardiovascular events and/or death. RESULTS: Thirty-one patients and thirteen controls were included. MIO (T2* < 20 ms) was detected in 9.7% of patients. Left ventricular global longitudinal strain (LV-GLS) by MR-FT was pathological (> −19.3%) in 32.3% of patients. Less negative strain values correlated with lower T2* (R = −0.37, p = 0.033) and native myocardial T1 (R = −0.39, p = 0.031) times. LV-GLS by MR-FT was significantly associated with higher incidence of the combined cardiovascular events and/or all-cause death (p = 0.047), with a cut-off value of −17.7% for predicting them (63% sensitivity and 81% specificity, area under the curve = 0.69). After adjusting analysis including demographic, biomarkers and imaging variables, a higher LV-GLS value by MR-FT remained as predictor of combined event in transfusion-dependent LR-MDS patients (hazard ratio, 0.4; confidence interval, 0.15–0.98; p = 0.045). CONCLUSIONS: Longitudinal myocardial strain by MR-FT in LR-MDS patients is associated to MIO and correlates with adverse events in the follow-up, what could serve as a prognostic tool.
L. Molinero,J. Esteban,F. Sanchez,F. Garcia-Ochoa,M. Ladero 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.109 No.-
As a way to valorise glycerol, the main by-product of biodiesel, this study is focused on the production ofesters of p-methoxycinnamic acid and glycerol. These esters can replace hazardous octylmethoxycinnamatein the cosmetic industry, which is thought to act as an endocrine disruptor and can interfere withthyroid function. Several sulfonated mesoporous catalysts, with and without endcapping, were easilysynthetized using several alcohols as porogens. These catalysts were characterized for structure and surfacearea, chemical composition and acidity, and tested under solventless conditions for the esterificationof glycerol with p-methoxycinnamic acid. Their activity was similar to that of p-toluenesulfonic acid. Thebest catalysts for the reaction under study was the end-capped mesoporous solid prepared in isopropanol. Finally, the selected catalyst was tested in 9 runs conducted at 150–170 C and at molar ratiosglycerol:p-methoxycinnamic acid ranging from 3:1 to 9:1. The kinetic model that better fits to the experimentaldata comprises two esterification reactions in-series and a first-order catalyst deactivation. Theactivation energies were 87.33 ± 5.67 kJ mol1 for the average esterification to the monoglycerides, 69. 17 ± 9.84 kJ mol1 in average for the reactions yielding the diglycerides, and 104.00 ± 15.30 kJ mol1for the catalyst deactivation.