http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Enyu Song (검색결과 4 건)
- 무료
- 기관 내 무료
- 유료
-
-
Flavone Attenuates Vascular Contractions by Inhibiting RhoA/Rho Kinase Pathway
Inji Baek,Su Bun Jeon,Min-Ji Song,Enyue Yang,Uy Dong Sohn,In Kyeom Kim 대한생리학회-대한약리학회 2009 The Korean Journal of Physiology & Pharmacology Vol.13 No.3
Our previous study demonstrated that flavone inhibits vascular contractions by decreasing the phosphorylation levelof the myosin phosphatase target subunit (MYPT1). In the present study, we hypothesized that flavone attenuates vascular contractions through the inhibition of the RhoA/Rho kinase pathway. Rat aortic rings were denuded of endothelium, mounted in organ baths, and contracted with either 30 nM U46619 (a thromboxane A2 analogue) or 8.0 mM NaF 30 min after pretreatment with either flavone (100 or 300ՌM) or vehicle. We determined the phosphorylation level of the myosin light chain (MLC<sub>20</sub>), the myosin phophatase targeting subunit 1 (MYPT1) and the protein kinase C-potentiated inhibitory protein for heterotrimeric myosin light chain phophatase of 17-kDa (CPI17) by means of Western blot analysis. Flavone inhibited, not only vascular contractions induced by these contractors, but also the levels of MLC<sub>20</sub> phosphorylation. Furthermore, flavone inhibited the activation of RhoA which had been induced by either U46619 or NaF. Incubation with flavone attenuated U46619- or NaF-induced phosphorylation of MYPT1<sup>Thr855</sup> and CPI17<sup>Thr38</sup>, the downstream effectors of Rho-kinase. In regards to the Ca<sup>2+</sup>-free solution, flavone inhibited the phosphorylation of MYPT1<sup>Thr855</sup> and CPI17<sup>Thr38</sup>, as well as vascular contractions induced by U46619. These results indicate that flavone attenuates vascular contractions, at least in part, through the inhibition of the RhoA/Rho-kinase pathway.
-
Flavone Attenuates Vascular Contractions by Inhibiting RhoA/Rho Kinase Pathway
Baek, In-Ji,Jeon, Su-Bun,Song, Min-Ji,Yang, Enyue,Sohn, Uy-Dong,Kim, In-Kyeom The Korean Society of Pharmacology 2009 The Korean Journal of Physiology & Pharmacology Vol.13 No.3
Our previous study demonstrated that flavone inhibits vascular contractions by decreasing the phosphorylation levelof the myosin phosphatase target subunit (MYPT1). In the present study, we hypothesized that flavone attenuates vascular contractions through the inhibition of the RhoA/Rho kinase pathway. Rat aortic rings were denuded of endothelium, mounted in organ baths, and contracted with either 30 nM U46619 (a thromboxane A2 analogue) or 8.0 mM NaF 30 min after pretreatment with either flavone (100 or 300 $({\mu}M$) or vehicle. We determined the phosphorylation level of the myosin light chain ($MLC_{20}$), the myosin phophatase targeting subunit 1 (MYPT1) and the protein kinase C-potentiated inhibitory protein for heterotrimeric myosin light chain phophatase of 17-kDa (CPI17) by means of Western blot analysis. Flavone inhibited, not only vascular contractions induced by these contractors, but also the levels of $MLC_{20}$ phosphorylation. Furthermore, flavone inhibited the activation of RhoA which had been induced by either U46619 or NaF. Incubation with flavone attenuated U46619 or NaF-induced phosphorylation of $MYPT1^{Thr855}$ and $CPI17^{Thr38}$, the downstream effectors of Rho-kinase. In regards to the $Ca^{2+}$-free solution, flavone inhibited the phosphorylation of $MYPT1^{Thr855}$ and $CPI17^{Thr38}$, as well as vascular contractions induced by U 46619. These results indicate that flavone attenuates vascular contractions, at least in part, through the inhibition of the RhoA/Rho-kinase pathway.
-
Error modeling and accuracy optimization of rotating ultrasonic vibration assisted EDM machine tool
Minggang Xu,Zhiwei Wu,Feng Gao,Linlin Liu,Enyu Song 대한기계학회 2020 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.34 No.7
Rotating ultrasonic vibration assisted EDM is a composite machining method that uses EDM to etch a metal surface and adds rotating and ultrasonic vibration. It has high efficiency and a wide range of workpiece materials. Aiming at the structural characteristics of rotary ultrasonic vibration assisted EDM machine tool, the errors caused by the main moving parts of the machine tool were analyzed. The structure relationship is described by multi-body system theory, and the geometric error model is deduced by homogeneous coordinate transformation method. The aim was to improve the overall accuracy, reduce the cost, trace the error source, and get the corresponding relationship between the basic geometric errors and the precision parameters of the related parts. Under the requirement of ensuring the overall accuracy, an optimization function was established that minimizes the cost and relaxes all accuracy parameters to the greatest extent. Finally, MATLAB and its genetic algorithm toolbox was used for analysis. Verification shows that this model can properly reduce the cost on the premise of ensuring the accuracy.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
