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An Overview on Wound Dressings and Sutures Fabricated by Electrospinning
Rezvan Mohamadinooripoor,Soheila Kashanian,Elham Arkan 한국생물공학회 2023 Biotechnology and Bioprocess Engineering Vol.28 No.1
Electrospinning is simple and cost-effective technique for micro/nano-fibers production that have emerged recently. Electrospun fibers have a wide variety of applications. They can provide ideal wound dressings, and so exhibit significant potential in production of therapeutic loaded sutures. Wound treatments have a huge commercial enterprise and the demand of them are increasing day by day. Thus, it seems essential to summarize wound dressings and sutures which were prepared using electrospinning technique. In this review, we will investigate the wound healing processes and the process of electrospinning and also the effective parameters of the process. Future directions of this compilation will explore kinds of electrospun wound dressing and sutures.
Leila Behbood,Soroush Karimi,Esmaeil Mirzaei,Ghobad Mohammadi,Mahsa Azami,Elham Arkan 한국섬유공학회 2018 Fibers and polymers Vol.19 No.7
The mucoadhesive Chitosan (CS) nanofibers as a drug delivery system were developed. Chitosan was modified via the immobilization of thiol groups from L-cysteine as a mucoadhesive reagent. The mucoadhesive properties of the chitosan nanofibers were evaluated by tensiometer set and via tensile studies. Drug and mucoadhesive agent loading lead to decrease diameters and increased porous of nanofibers. The release of Tetracycline (Tet) and Triamcinolone (Tri) were increased with increasing immersion time and it became constant at long immersion times. Mucoadhesion studies were done at pH 2-7 and in pH 6 maximum mucoadhesive properties observed. Release studies demonstrated a sustained release of both drug continued up to 48 hours. Microbial studies were performed on the nanofibers. The drug delivery system represented a novel tool for improve the therapeutic efficacy of various drugs that are poorly absorbed from the gastrointestinal tract. Also it is an efficient system for treatment of oral ulceration.