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RISS 인기검색어
- 검색키워드
- 저자 : Elamin M. Elamin (검색결과 3 건)
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Clinical and Prognostic Features of Erionite-Induced Malignant Mesothelioma
Ersin Demirer,Elamin M. Elamin,Christian F. Ghattas,Mohamed O. Radwan 연세대학교의과대학 2015 Yonsei medical journal Vol.56 No.2
This review analytically examines the published data for erionite-related malignantpleural mesothelioma (E-MPM) and any data to support a genetically predisposedmechanism to erionite fiber carcinogenesis. Adult patients of age ≥18 years with erionite-related pleural diseases and genetically predisposed mechanisms to erionite carcinogenesis were included, while exclusion criteria included asbestos- or tremolite-related pleural diseases. The search was limited to human studies though not limited to a specific timeframe. A total of 33 studies (31042 patients) including 22 retrospective studies, 6 prospective studies, and 5 case reports were reviewed. E-MPM developed in some subjects with high exposures to erionite, though not all. Chest CT was more reliable in detecting various pleural changes in E-MPM than chest X-ray, and pleural effusion was the most common finding in E-MPM cases, by both tests. Bronchoalveolar lavage remains a reliable and relatively less invasivetechnique. Chemotherapy with cisplatin and mitomycin can be administered either alone or following surgery. Erionite has been the culprit of numerous malignantmesothelioma cases in Europe and even in North America. Erionite has a higher degree of carcinogenicity with possible genetic transmission of erionite susceptibilityin an autosomal dominant fashion. Therapeutic management for E-MPM remains very limited, and cure of the disease is extremely rare.
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Ibrahim Abbas,M. Saif AlDien,Mawahib Elamin,Alaa El-Bary Techno-Press 2024 Coupled systems mechanics Vol.13 No.1
This study seeks to develop analytical solutions for the biothermoelastic model without accounting for energy dissipation. These solutions are then applied to estimate the temperature changes induced by external heating sources by integrating relevant empirical data characterizing the biological tissue of interest. The distributions of temperature, displacement, and strain were obtained by utilizing the eigenvalues approach with the Laplace transforms and numerical inverse transforms method. The impacts of the rate of blood perfusion and the metabolic activity parameter on thermoelastic behaviors were discussed specifically. The temperature, displacement, and thermal strain results are visually represented through graphical representations.
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Oleuropein Induces Anti-metastatic Effects in Breast Cancer
Hassan, Zeinab K.,Elamin, Maha H.,Daghestani, Maha H.,Omer, Sawsan A.,Al-Olayan, Ebtesam M.,Elobeid, Mai A.,Virk, Promy,Mohammed, Osama B. Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.9
Breast cancer causes death due to distant metastases in which tumor cells produce matrix metalloproteinase (MMP) enzymes which facilitate invasion. Oleuropein, the main olive oil polyphenol, has anti-proliferative effects. This study aimed to investigate the effect of oleuropein on the metastatic and anti-metastatic gene expression in the MDA human breast cancer cell line. We evaluated the MMPs and TIMPs gene expression by semi-quantitative reverse transcriptase polymerase chain reaction (RT-PCR) in treated and untreated cells. This study demonstrated that OL may induce anti-metastatic effects on human breast cancer cells. We found that TIMP1,-3, and -4 were over-expressed after all periods of incubation in treated cancer cells compared to untreated cells, while MMP2 and MMP9 genes were down-regulated, at least initially. Treatment of breast cancer cells with oleuropein could help in prevention of cancer metastasis by increasing the TIMPs and suppressing the MMPs gene expressions.
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