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Jatuporn Phaopongthai,Suthep Wiyakrutta,Duangdeun Meksuriyen,Nongluksna Sriubolmas,Khanit Suwanborirux 한국미생물학회 2013 The journal of microbiology Vol.51 No.6
In this study, a tropical endophytic fungus, Alternaria alternata Tche-153 was isolated from a Thai medicinal plant Terminalia chebula Rezt. The ethyl acetate extract prepared from the fermentation broth exhibited significant ketoconazole-synergistic activity against Candida albicans. Bioassaydirected fractionation of the ethyl acetate extract led to the isolation of altenusin (1), isoochracinic acid (2), and altenuic acid (3) together with 2,5-dimethyl-7-hydroxychromone (4). Using the disc diffusion method and the microdilution chequerboard technique, only altenusin (1) in combination with each of three azole drugs, ketoconazole, fluconazole or itraconazole at their low sub-inhibitory concentrations exhibited potent synergistic activity against C. albicans with the fractional inhibitory concentration index range of 0.078 to 0.188. This first discovery of altenusin (1) as a new azole-synergistic prototype possessing a biphenyl structure is of significance for further development of new azole-synergists to treat invasive candidiasis.
Lee Juian Lin,Duangdeun Meksuriyen,Geoffrey A. Cordell,Won Sick Woo,Chung Kyu Lee 한국생약학회 1987 생약학회지 Vol.18 No.2
The structure of the neolignan americanin A was confirmed to be 2, through the application of the Selective INEPT NMR technique. Complete and unambiguous proton and <sup>13</sup>C-NMR assignments are provided.
Nonthaneth Nalinratana,Weeraya Kaewprem,Sarunya Tongumpai,Rataya Luechapudiporn,Uthai Sotanaphun,Duangdeun Meksuriyen 한국한의학연구원 2014 Integrative Medicine Research Vol.3 No.2
Background: Phikud Navakot (PN), a combination of nine herbs, has been used traditionally inThai medicinal formulas to relieve circulatory disorder. The present study aimed to comparethe synergistic antioxidant efficacy and toxicity of the hydroethanolic and water extracts ofPN at cellular level.Methods: PN and its nine herbs were extracted with either 50% ethanol or water. All extractswere tested for in vitro antioxidant potential using standard antioxidant assays. Evaluationof cytotoxicity, genotoxicity, and intracellular reactive oxygen species were performed usinghuman endothelial ECV304 cells.Results: Antioxidant assays in cell-free systems showed that the hydroethanolic extractof PN scavenged superoxide, hydroxyl, nitric oxide radicals, and hydrogen peroxide moreeffectively than its water extract. Combination indices were calculated to show that theingredients of the hydroethanolic extract acted synergistically to exhibit antioxidant activi-ties against all tested radicals, whereas, in the case of water extract, this effect was observedonly against 2,2-diphenyl-1-picrylhydrazyl, superoxide, and hydroxyl radicals. A cell-basedassay also revealed that the hydroethanolic extract concentration-dependently attenuatedhydrogen peroxide-induced stress more effectively than the water extract. At the antioxi-dant and cytotoxic concentrations of both extracts, no genotoxicity was found.Conclusion: Our findings demonstrate that the synergistic antioxidant action of PN amelio-rates endothelial stress, which may provide some clues for understanding the traditionaluse of PN for the treatment of circulatory disorder. Additionally, the selection of a suitablesolvent for the extraction of PN herbal combination is essential for maximal efficacy andsafety