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RISS 인기검색어
- 검색키워드
- 저자 : Dosso, Mireille (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
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Kouadio, Kouame,Zheng, Kui-Cheng,Toure, Abdoulaye Abba,Dosso, Mireille,Todoriki, Hidemi The Korean Society for Preventive Medicine 2014 Journal of Preventive Medicine and Public Health Vol.47 No.1
Objectives: We established a Wistar rat model of asthma caused by toluene diisocyanate (TDI) exposure, and investigated the relationship between TDI exposure concentrations and respiratory hypersensitivity, airway inflammation, and cytokine secretions in animals, to better understand the mechanism of TDI induced occupational asthma. Methods: Wistar rats were exposed to two different concentrations of TDI vapor four hours a day for five consecutive days. Bronchoalveolar lavage (BAL) was performed, and differential leucocytes from the BAL fluid were analyzed. Lung histopathological examination was carried out to investigate the inflammatory status in the airways. Production of cytokines interleukin (IL)-4 and IL-5 productions in the BAL fluid in vivo was determined with enzyme-linked immunosorbent assay kits. Results: The TDI-exposed rats exhibited greater airway hypersensitivity symptoms than the control rats. The BAL differential cell count and lung histopathological examination demonstrated that inflammation reactions were present in both the central and peripheral airways, characterized with marked infiltration of eosinophils in the TDI-exposed rats. The cytokine assay showed that IL-4 and IL-5 were predominantly produced in the BAL fluid in vivo. Conclusions: These findings imply that TDI exposure concentrations may greatly affect the occurrence and extent of inflammatory events and that Th2 type cytokines may play an important role in the immunopathogenesis of TDI-induced occupational respiratory hypersensitivity.
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Kouame Kouadio,Kui-Cheng Zheng,Abdoulaye Abba Toure,Mireille Dosso,Hidemi Todoriki 대한예방의학회 2014 Journal of Preventive Medicine and Public Health Vol.47 No.1
Objectives: We established a Wistar rat model of asthma caused by toluene diisocyanate (TDI) exposure, and investigated the relationshipbetween TDI exposure concentrations and respiratory hypersensitivity, airway inflammation, and cytokine secretions in animals,to better understand the mechanism of TDI induced occupational asthma. Methods: Wistar rats were exposed to two different concentrations of TDI vapor four hours a day for five consecutive days. Bronchoalveolarlavage (BAL) was performed, and differential leucocytes from the BAL fluid were analyzed. Lung histopathological examination was carried out to investigate the inflammatory status in the airways. Production of cytokines interleukin (IL)-4 and IL-5 productions in the BAL fluid in vivo was determined with enzyme-linked immunosorbent assay kits. Results: The TDI-exposed rats exhibited greater airway hypersensitivity symptoms than the control rats. The BAL differential cell count and lung histopathological examination demonstrated that inflammation reactions were present in both the central and peripheral airways, characterized with marked infiltration of eosinophils in the TDI-exposed rats. The cytokine assay showed that IL-4 and IL-5 were predominantly produced in the BAL fluid in vivo. Conclusions: These findings imply that TDI exposure concentrations may greatly affect the occurrence and extent of inflammatory events and that Th2 type cytokines may play an important role in the immunopathogenesis of TDI-induced occupational respiratory hypersensitivity.
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Bernadette Gblossi Goualié,Honoré Gnenequidou Ouattara,Eric Essoh Akpa,Nathalie kouadio Guessends,Souleymane Bakayoko,Sébastien Lamine Niamké,Mireille Dosso 한국식품과학회 2014 Food Science and Biotechnology Vol.23 No.4
The level of antibiotic multiresistance ofCampylobacter strains from chicken was evaluated andresponses to the bactericidal effects of organic acids wereanalyzed. Strains (76) isolated from chicken were analyzedfor resistance to antibiotics and acid shock. A high strainresistance to fluoroquinolones (ciprofloxacin and nalidixicacid) was observed, with cross resistance to both drugs in41% of strains. A low resistance was observed for amoxicillin,erythromycin, and gentamicin. Campylobacter jejuni wasthe most resistant species. Antibacterial activities againstmultiresistant Campylobacter strains were observed usingacetic, citric, and ascorbic acids at minimum bactericidalconcentrations (MBC) ranging from 0.3 to 3 mg/mL. Acetic acid was the most efficient acid with the lowestMBC value. However, a contact time of 4 h was requiredfor an efficient effect against Campylobacter contaminatedchicken skin. Using organic acids in the poultry productionchain can reduce propagation of antibiotic multiresistantstrains of Campylobacter.
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