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광-전자파 기반 20 GHz급 펄스 샘플링 오실로스코프
이동준(Dong-Joon Lee),강노원(No-Weon Kang),이주광(Joo-Gwang Lee),강태원(Tae-Weon Kang) 한국전자파학회 2011 한국전자파학회논문지 Vol.22 No.10
본 논문에서는 전자 소자 기반의 상용 오실로스코프에 의한 기존의 펄스 신호 측정 방법의 주파수 한계를 극복하기 위하여 전기광학 기반의 측정 방법을 기술하였다. 펄스폭 0.1 ps의 펨토초 레이저와 광다이오드를 사 용하여 20 GHz 주파수 범위에 대응되는 전자기 펄스를 발생시키고, 마이크로스트립 선로를 통해 전송되는 전자기 펄스를 검출하기 위하여 전기광학 샘플링 기법을 이용하였다. 마이크로스트립 선로 위의 매우 근접한 거리에서 광학 결정 프로브를 이용하여 비접촉식으로 펄스 신호를 검출하고, 선로의 출력단 펄스 신호를 기존의 오실로스코프로 측정하여 두 측정 결과를 서로 비교하였다. This paper presents an optical sampling technique which can be used to overcome the limited bandwidth of a commercial electronic sampling oscilloscope for pulsed signal measurement. Employing an ultrafast laser with 0.1 ps pulse duration, 20 GHz electromagnetic pulses were generated through a fast photodiode. These pulses were transmitted through a microstrip line and sampled with an optically triggered electro-optic system. Two sampled 20 GHz pulses - measured independently over the transmission line with a non-contacting electro-optic method and conventional electronic one through a coaxial cable - were compared.
Kim, Hyun-Yi,Yang, Dong-Hwa,Shin, Song-Weon,Kim, Mi-Yeon,Yoon, Jae-Hyun,Kim, Suhyun,Park, Hae-Chul,Kang, Dong Woo,Min, DoSik,Hur, Man-Wook,Choi, Kang-Yell The Federation of American Societies for Experimen 2014 The FASEB Journal Vol.28 No.2
<P>CXXC5 is a member of a small subset of proteins containing CXXC-type zinc-finger domain. Here, we show that CXXC5 is a transcription factor activating <I>Flk-1</I>, a receptor for vascular endothelial growth factor. CXXC5 and Flk-1 were accmulated in nucli and membrane of mouse embryonic stem cells (mESCs), respectively, during their endothelial differentiation. CXXC5 overexpression induced <I>Flk-1</I> transcription in both endothelium-differentiated mESCs and human umbilical vein endothelial cells (HUVECs). <I>In vitro</I> DNA binding assay showed direct interaction of CXXC5 on the <I>Flk-1</I> promoter region, and mutation on its DNA-binding motif abolished transcriptional activity. We showed that bone morphorgeneic protein 4 (BMP4) induced <I>CXXC5</I> transcription in the cells, and inhibitors of BMP signaling suppressed the <I>CXXC5</I> induction and the consequent <I>Flk-1</I> induction by BMP4 treatment. <I>CXXC5</I> knockdown resulted in suppression of BMP4-induced stress fiber formation (56.8±1.3% decrease, <I>P</I><0.05) and migration (54.6±1.9% decrease, <I>P</I><0.05) in HUVECs. The <I>in vivo</I> roles of CXXC5 in BMP-signaling-specific vascular development and angiogenesis were shown by specific defect of caudal vein plex vessel formation (57.9±11.8% decrease, <I>P</I><0.05) in <I>cxxc5</I> morpholino-injected zebrafish embryos and by supression of BMP4-induced angigogensis in subcutaneously injected Matrigel plugs in <I>CXXC5</I><SUP>−/−</SUP> mice. Overall, CXXC5 is a transcriptional activator for <I>Flk-1</I>, mediating BMP signaling for differentiation and migration of endothelial cell and vessel formation.—Kim, H.-Y., Yang, D.-H., Shin, S.-W., Kim, M.-Y., Yoon, J.-H., Kim, S., Park, H.-C., Kang, D. W., Min, D., Hur, M.-W., Choi, K.-Y. CXXC5 is a transcriptional activator of <I>Flk-1</I> and mediates bone morphogenic protein-induced endothelial cell differentiation and vessel formation.</P>
( Dong Hoon Suh ),( Min A Kim ),( Hee Seung Kim ),( Hyun Hoon Chung ),( Ae Weon Kim ),( Noh Hyun Park ),( Yong Sang Song ),( Soon Beom Kang ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.98 No.-
To investigate the association between L1 cell adhesion molecule (L1CAM) expression and lymph node (LN) metastasis in diabetic patients with endometrial cancer (EC). A matched case control study was conducted with each 34 diabetic and non-diabetic EC patients. L1CAM expression was evaluated by immunohistochemistry and its correlation with LN metastasis was examined. Of the 68 patients, 13 (19.1%) were positive for L1CAM immunostaining: 6 (8.8%) in tumor cells and 7 (10.3%) in tumor stroma. Positive rate of L1CAM expression in diabetic EC patients was similar to that in non-diabetic EC patients, irrespective of the area of L1CAM expression (14.7% vs. 23.5%, p=.355). Of 64 who underwent lymphadenectomy, 8 (12.5%) had LN metastasis: 4 diabetic and 4 non-diabetic EC patients. At 50.5 months of the mean follow-up (range 2-113 months), a total of three recurrences: 2 diabetic and 1 non-diabetic patients. Tumor recurred more in the patients with positive L1CAM expression in tumor cells than those with negative L1CAM expression for all enrolled patients (33.3% vs. 1.6%, p=.019). However, we failed to find any significant association between L1CAM expression and LN metastasis for the entire subjects. Only for the diabetic EC patients (n = 34), patients with pelvic LN metastasis showed L1CAM expression in tumor cells more than those without LN metastasis (50.0% vs. 3.6%, p=.035). Nevertheless, there was no significant association between paraaortic LN metastasis and L1CAM expression in tumor cells as well as in tumor stroma (p>.05 for both). Advanced stage was the only risk factor for recurrence that showed a significant association with L1CAM expression in tumor cells, but not in tumor stroma, of EC patients (p=.014). Moreover, in a subgroup analysis with the diabetic EC patients, the significant relationship between advanced stage and L1CAM expression in tumor cells was also observed (p=.006). L1CAM expression is associated with pelvic LN metastasis and advanced stage in diabetic patients with EC.
Photonic-Assisted Reactive-Near-Field Analysis of a 3 ㏈-Tapered Ka-Band Array Antenna
Dong-Joon Lee,Jeong-Jin Kang,No-Weon Kang,Wan-Sik Kim,Wee Sang Park,Edward J. Rothwell,John F. Whitaker 한국전자파학회JEES 2010 Journal of Electromagnetic Engineering and Science Vol.10 No.1
A Ka-band microstrip array antenna for wide-range detection of moving targets is analyzed through a photonicassisted reactive-near-field characterization technique. The antenna array employs a 3-㏈-tapered feed network to suppress the sidelobe level while retaining a wide azimuth beamwidth for a wide detection range. The relative nearelectric field patterns of the array and its 3-㏈-tapered feed lines have been measured using an electro-optic fieldmapping technique for minimally invasive millimeter-wave sensing. A number of typical limitations on the technique, involving bandwidth, low signal-modulation depth, and high laser-induced noise in high-frequency applications, have been overcome by suppressing the carrier portion of the optical interrogation beam.