http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
The 72-h WEBT microvariability observation of blazar S5 0716 + 714 in 2009
Bhatta, G.,Webb, J. R.,Hollingsworth, H.,Dhalla, S.,Khanuja, A.,Bachev, R.,Blinov, D. A.,Bö,ttcher, M.,Bravo Calle, O. J. A.,Calcidese, P.,Capezzali, D.,Carosati, D.,Chigladze, R.,Collins, A.,Colo EDP Sciences 2013 Astronomy and astrophysics Vol.558 No.-
Comprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma
Ally, Adrian,Balasundaram, Miruna,Carlsen, Rebecca,Chuah, Eric,Clarke, Amanda,Dhalla, Noreen,Holt, Robert A.,Jones, Steven J.M.,Lee, Darlene,Ma, Yussanne,Marra, Marco A.,Mayo, Michael,Moore, Richard A Elsevier 2017 Cell Vol.169 No.7
<P><B>Summary</B></P> <P>Liver cancer has the second highest worldwide cancer mortality rate and has limited therapeutic options. We analyzed 363 hepatocellular carcinoma (HCC) cases by whole-exome sequencing and DNA copy number analyses, and we analyzed 196 HCC cases by DNA methylation, RNA, miRNA, and proteomic expression also. DNA sequencing and mutation analysis identified significantly mutated genes, including <I>LZTR1</I>, <I>EEF1A1</I>, <I>SF3B1</I>, and <I>SMARCA4</I>. Significant alterations by mutation or downregulation by hypermethylation in genes likely to result in HCC metabolic reprogramming (<I>ALB</I>, <I>APOB</I>, and <I>CPS1</I>) were observed. Integrative molecular HCC subtyping incorporating unsupervised clustering of five data platforms identified three subtypes, one of which was associated with poorer prognosis in three HCC cohorts. Integrated analyses enabled development of a p53 target gene expression signature correlating with poor survival. Potential therapeutic targets for which inhibitors exist include WNT signaling, MDM4, MET, VEGFA, MCL1, IDH1, TERT, and immune checkpoint proteins CTLA-4, PD-1, and PD-L1.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Analysis of hepatocellular carcinomas integrates data of multiple genomic platforms </LI> <LI> Mutated genes reveal oncogenic processes altering hepatocyte energy balance </LI> <LI> Multiplex analyses suggest a key role for Sonic hedgehog signaling in HCC </LI> <LI> IDH mutations point to a HCC subgroup molecularly similar to cholangiocarcinoma </LI> </UL> </P> <P><B>Graphical Abstract</B></P> <P>[DISPLAY OMISSION]</P>