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인구구조 변화와 사회보장 재정의 사회경제적 파급효과 연구(2차년도)
원장욱,장인수,( Jinkook Lee ),( Ltab Lopez Garcia ),( David M. K. Knapp ) 한국보건사회연구원 2016 한국보건사회연구원 연구보고서 Vol.2016 No.-
It is the second year work of three-year project of modeling effect of social security finance to the macro-economy and household decision making in retirement timing and saving. In 2015, we have built three quantitative models of Social accounting matrix, Macro econometric model, and dynamic behavioral model that can evaluate impact of social security finance to the macro-economy and household decision making. In 2016, we tested impact of national pension finance toward macro and micro economy by utilizing three different models. We tested situation of contribution increase from 9% to 11%, and found that influx of pension fund to economy could produce positive effect in GDP growth rate despite of diminishing disposable income due to increase in contribution rate. However as portion of overseas investment of national pension fund increases the positive effect on GDP growth rate diminish or turn to negative effect. In micro level, we have tested contribution increase to observe pension participants timing of retirement and level of saving using dynamic programming. With 2% point increase in contribution rate, on average, people tend to retire earlier than before and save less. In 2016 work of dynamic analysis, we have utilized actual reported income data from NPS to match KLoSA data as cell type merge. By doing this, we obtained better estimate of pension benefit and real income. Also, we could increase sample size by including self-employed that was deleted due to lack of information to estimate income. We will continue to extend dynamic programming model to add health effect or health insurance effect top of pension model in 2017. We hope that our three-year work on modeling effect of social security finance could enhance feasibility of policy experiment in social security system and finance.
Highly stable trypsin-aggregate coatings on polymer nanofibers for repeated protein digestion
Kim, Byoung Chan,Lopez-Ferrer, Daniel,Lee, Sang-Mok,Ahn, Hye-Kyung,Nair, Sujith,Kim, Seong H.,Kim, Beom Soo,Petritis, Konstantinos,Camp, David G.,Grate, Jay W.,Smith, Richard D.,Koo, Yoon-Mo,Gu, Man B WILEY-VCH Verlag 2009 Proteomics Vol.9 No.7
<P>A stable and robust trypsin-based biocatalytic system was developed and demonstrated for proteomic applications. The system utilizes polymer nanofibers coated with trypsin aggregates for immobilized protease digestions. After covalently attaching an initial layer of trypsin to the polymer nanofibers, highly concentrated trypsin molecules are crosslinked to the layered trypsin by way of a glutaraldehyde treatment. This process produced a 300-fold increase in trypsin activity compared with a conventional method for covalent trypsin immobilization, and proved to be robust in that it still maintained a high level of activity after a year of repeated recycling. This highly stable form of immobilized trypsin was resistant to autolysis, enabling repeated digestions of BSA over 40 days and successful peptide identification by LC-MS/MS. This active and stable form of immobilized trypsin was successfully employed in the digestion of yeast proteome extract with high reproducibility and within shorter time than conventional protein digestion using solution phase trypsin. Finally, the immobilized trypsin was resistant to proteolysis when exposed to other enzymes (i.e., chymotrypsin), which makes it suitable for use in “real-world” proteomic applications. Overall, the biocatalytic nanofibers with trypsin aggregate coatings proved to be an effective approach for repeated and automated protein digestion in proteomic analyses.</P>
Apalutamide Treatment and Metastasis-free Survival in Prostate Cancer
Smith, Matthew R.,Saad, Fred,Chowdhury, Simon,Oudard, Sté,phane,Hadaschik, Boris A.,Graff, Julie N.,Olmos, David,Mainwaring, Paul N.,Lee, Ji Youl,Uemura, Hiroji,Lopez-Gitlitz, Angela,Trudel, G&e New England Journal of Medicine 2018 The New England journal of medicine Vol.378 No.15
<P>Among men with nonmetastatic castration-resistant prostate cancer, metastasis-free survival and time to symptomatic progression were significantly longer with apalutamide than with placebo.</P>