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Opioid induced hyperalgesia in anesthetic settings
이현정,David C. Yeomans 대한마취통증의학회 2014 Korean Journal of Anesthesiology Vol.67 No.5
Pain is difficult to investigate and difficult to treat, in part, because of problems in quantification and assessment. The useof opioids, combined with classic anesthetics to maintain hemodynamic stability by controlling responses to intraoperativepainful events has gained significant popularity in the anesthetic field. However, several side effects profiles concerningperioperative use of opioid have been published. Over the past two decades, many concerns have arisen with respectto opioid-induced hyperalgesia (OIH), which is the paradoxical effect wherein opioid usage may decrease pain thresholdsand increase atypical pain unrelated to the original, preexisting pain. This brief review focuses on the evidence,mechanisms, and modulatory and pharmacologic management of OIH in order to elaborate on the clinical implicationof OIH.