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RISS 인기검색어
- 검색키워드
- 저자 : David B. Robinson (검색결과 3 건)
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Presynaptic Regulation of Astroglial Excitatory Neurotransmitter Transporter GLT1
Yang, Yongjie,Gozen, Oguz,Watkins, Andrew,Lorenzini, Ileana,Lepore, Angelo,Gao, Yuanzheng,Vidensky, Svetlana,Brennan, Jean,Poulsen, David,Won Park, Jeong,Li Jeon, Noo,Robinson, Michael B.,Rothstein, J Elsevier 2009 Neuron Vol.61 No.6
<P><B>Summary</B></P><P>The neuron-astrocyte synaptic complex is a fundamental operational unit of the nervous system. Astroglia regulate synaptic glutamate, via neurotransmitter transport by GLT1/EAAT2. Astroglial mechanisms underlying this essential neuron-glial communication are not known. We now show that presynaptic terminals regulate astroglial synaptic functions, GLT1/EAAT2, via kappa B-motif binding phosphoprotein (KBBP), the mouse homolog of human heterogeneous nuclear ribonucleoprotein K (hnRNP K), which binds the GLT1/EAAT2 promoter. Neuron-stimulated KBBP is required for GLT1/EAAT2 transcriptional activation and is responsible for astroglial alterations in neural injury. Denervation of neuron-astrocyte signaling by corticospinal tract transection, ricin-induced motor neuron death, or neurodegeneration in amyotrophic lateral sclerosis all result in reduced astroglial KBBP expression and transcriptional dysfunction of astroglial transporter expression. Presynaptic elements dynamically coordinate normal astroglial function and also provide a fundamental signaling mechanism by which altered neuronal function and injury leads to dysregulated astroglia in CNS disease.</P>
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Effect of Ordered Intermediate Porosity on Ion Transport in Hierarchically Nanoporous Electrodes
Chae, Weon-Sik,Gough, Dara Van,Ham, Sung-Kyoung,Robinson, David B.,Braun, Paul V. American Chemical Society 2012 ACS APPLIED MATERIALS & INTERFACES Vol.4 No.8
<P>The high surface area of nanoporous electrodes makes them promising for use in electrochemical double-layer supercapacitors, desalination and pollution remediation, and drug delivery applications. When designed well and operating near their peak power, their charging rates are limited by ion transport through their long, narrow pores. This can be alleviated by creating pores of intermediate diameter that penetrate the electrode. We have fabricated electrodes featuring these by creating colloidal crystal-templated opals of nanoporous gold formed by dealloying. The resulting electrodes contain a bimodal pore-size distribution, with large pores on the order of several 100 nm and small pores on the order of 10 nm. Electrochemical impedance spectrometry shows that porous gold opals sacrifice some capacitance, but possess a lower internal resistance, when compared to a porous gold electrode with only the smaller-diameter pores. The architectural flexibility of this approach provides a greater ability to design a balance between power density and energy density.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/aamick/2012/aamick.2012.4.issue-8/am300798j/production/images/medium/am-2012-00798j_0010.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/am300798j'>ACS Electronic Supporting Info</A></P>
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Bimodal Porous Gold Opals for Molecular Sensing
채원식,유현웅,Sung-Kyoung Ham,Myung-Jin Lee,Jin-Seung Jung,David B. Robinson 대한금속·재료학회 2013 ELECTRONIC MATERIALS LETTERS Vol.9 No.6
We have fabricated bimodal porous gold skeletons by double-templating routes using poly(styrene) colloidal opals as templates. The fabricated gold skeletons show a bimodal pore-size distribution, with small pores within spheres and large pores between spheres. The templated bimodal porous gold skeletons were applied in Raman scattering experiments to study sensing efficiency for probe molecules. We found that the bimodal porous gold skeletons showed obvious enhancement of Raman scattering signals versus that of the unimodal porous gold which only has interstitial pores of several hundred nanometers.
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