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Systematic Reviews of Sport for Development Literature: Managerial and Policy Implications
Simon C.Darnell,Meredith A. Whitley,Martin Camiré,William V. Massey,Lindsey C. Blom,Megan Chawansky,Shawn Forde,Laura Hayden 글로벌지식마케팅경영학회 2022 Journal of Global Sport Management Vol.7 No.2
This paper reports findings of two systematic reviews of Sport for Development (SfD) evidence, with a particular focus on manager- ial and policy implications. We suggest that the outcomes of the systematic reviews yield significant insights regarding the current state of the SfD literature, particularly with respect to the diversity of interventions, the importance of scale and context, and the general paucity of rigorous, empirical analyses. In turn, we pro- pose that several managerial and policy implications and recom- mendations can be gleaned from these assessments, including the importance of an ongoing and even renewed commitment to theory and context, and critical considerations of the structure of the SfD field itself. We also use the results of the reviews to make suggestions about the importance of future research in this area, as well as the kind of research that is needed, in both policy and programming terms.
RNA Regulation in Neurologic Disease and Cancer
Robert B. Darnell 대한암학회 2010 Cancer Research and Treatment Vol.42 No.3
The paraneoplastic neurologic diseases (PNDs) are brain degenerations that develop in the setting of clinically inapparent cancers. PNDs arise when common cancers express brain proteins, triggering an anti-tumor immune response and tumor immunity. Research on these brain-cancer proteins has revealed a new world of neuron-specific RNA binding proteins whose functions may be aberrantly used by tumor cells. Efforts to gain insight into their function has led to the development of new methods and strategies to understand RNA protein regulation in living tissues.
Ince-Dunn, G.,Okano, Hirotaka J.,Jensen, K.B.,Park, W.Y.,Zhong, R.,Ule, J.,Mele, A.,Fak, John J.,Yang, C.,Zhang, C.,Yoo, J.,Herre, M.,Okano, H.,Noebels, Jeffrey L.,Darnell, Robert B. Cell Press 2012 Neuron Vol.75 No.6
The paraneoplastic neurologic disorders target several families of neuron-specific RNA binding proteins (RNABPs), revealing that there are unique aspects of gene expression regulation in the mammalian brain. Here, we used HITS-CLIP to determine robust binding sites targeted by the neuronal Elav-like (nElavl) RNABPs. Surprisingly, nElav protein binds preferentially to GU-rich sequences in vivo and in vitro, with secondary binding to AU-rich sequences. nElavl null mice were used to validate the consequence of these binding events in the brain, demonstrating that they bind intronic sequences in a position dependent manner to regulate alternative splicing and to 3'UTR sequences to regulate mRNA levels. These controls converge on the glutamate synthesis pathway in neurons; nElavl proteins are required to maintain neurotransmitter glutamate levels, and the lack of nElavl leads to spontaneous epileptic seizure activity. The genome-wide analysis of nElavl targets reveals that one function of neuron-specific RNABPs is to control excitation-inhibition balance in the brain. Video Abstract: