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Francilene V. Silva,Irisdalva S. Oliveira,Kayo A. Figueiredo,Francisco B. Melo Junior,Danielly A. Costa,Mariana H. Chaves,Mauricio P.M. Amaral,Fernanda R.C. Almeida,Francisco A. Oliveira,Rita C.M. Oli 한국식품영양과학회 2014 Journal of medicinal food Vol.17 No.6
The present work reports the anti-inflammatory and antinociceptive activities of the ethanol extract obtained from the stem bark of Sterculia striata A. St.-Hil. & Naudin (Ss-EtOH) in the experimental models of edema induced by carrageenan, dextran, or histamin and nociception induced by chemical stimuli, such as acetic acid, formalin, capsaicin, or glutamate. The Ss-EtOH (50 mg/kg) promoted a marked inhibition on the hind paw edema induced by carrageenan or dextran (30% and 73%, respectively). Besides, Ss-EtOH (25 mg/kg) exhibited a slight activity (30%) on the hind paw edema induced by histamin. The Ss-EtOH (12.5 and 25 mg/kg) showed the antinociceptive activity on chemical stimuli induced by acetic acid (65.59% and 38.37%, respectively), formalin, in the initial (35.08% and 31.5%, respectively) and late phases (44.09% and 83.57%, respectively), capsaicin (43.77% and 51.31%, respectively), or glutamate (36.6% and 52.12%, respectively). Regarding the possible mechanism involved in the antinociceptive effect, Ss-EtOH (12.5 mg/kg) showed a decrease in the antinociceptive effect (65.8%) in the acetic acid model after pretreatment with naloxone. Thus, opioid mechanisms might be underlying this response.
Virginia D. Kappel,Geison M. Costa,Gustavo Scola,Francilene A. Silva,Melissa F. Landell,Patr?cia Valente,Daiana G. Souza,Danielli C. Vanz,Fl?vio H. Reginatto,Jos? C.F. Moreira 한국식품영양과학회 2008 Journal of medicinal food Vol.11 No.2
The phenolic content, antioxidant potential, and antimicrobial activity of extracts of different parts of the fruitfrom Capsicum baccatumL. var. pendulumwere investigated. The analysis of phenolic content was performed by the Folin-Ciocalteu method and reversed-phase high-performance liquid chromatography. The in vitroantioxidant activity was assessedby the total reactive antioxidant potential and total antioxidant reactivity index. The antioxidant activity was positively cor-related with the amount of phenolics found in each sample. The ex vivoantioxidant potential was assessed using the rat liverslice model. The antimicrobial activity was screened using Gram-positive and Gram-negative bacteria and fungi. All the ex-tracts revealed antioxidant activity and a weak antimicrobial activity.