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Howaida I. Abd-Alla,Dalila Souguir,Mohamed O. Radwan 대한약학회 2021 Archives of Pharmacal Research Vol.44 No.11
Sophora is deemed as one of the most remarkablegenera of Fabaceae, and the third largest family offl owering plants. The genus Sophora comprises approximately52 species, 19 varieties, and 7 forms that are widelydistributed in Asia and mildly in Africa. Sophora speciesare recognized to be substantial sources of broad spectrumbiopertinent secondary metabolites namely fl avonoids, isoflavonoids, chalcones, chromones, pterocarpans, coumarins,benzofuran derivatives, sterols, saponins (mainly triterpeneglycosides), oligostilbenes, and mainly alkaloids. Meanwhile,extracts and isolated compounds from Sophora havebeen identifi ed to possess several health-promising eff ectsincluding anti-infl ammatory, anti-arthritic, antiplatelets,antipyretic, anticancer, antiviral, antimicrobial, antioxidant,anti-osteoporosis, anti-ulcerative colitis, antidiabetic, antiobesity,antidiarrheal, and insecticidal activities. Herein,the present review aims to provide comprehensive detailsabout the phytochemicals and biological eff ects of Sophoraspecies. The review spotlighted on the promising phytonutrientsextracted from Sophora and their plethora of bioactivities. The review also clarifi es the remaining gapsand thus qualifi es and supplies a platform for further investigationsof these compounds.