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Experimental Investigations on VIV of Bridge Deck Sections: A Case Study
Zeng-shun Chen,Si-meng Liu,Xianfeng Yu,Cun-ming Ma,Lei Liu 대한토목학회 2017 KSCE Journal of Civil Engineering Vol.21 No.7
In this paper, the Vortex Induced Vibrations (VIVs) of bridge deck sections of the Hong Kong-Zhuhai-Macao Bridge were investigated experimentally. Aeroelastic tests for the bridge deck of two scale ratios (1:20 model and 1:50 model) under different wind attack angles, wind speeds, and damping ratios were performed. Accessory and windbreak effects on the VIVs of the bridge deck were also carried out. The experimental results show that the accessory and windbreak tend to enlarge the VIVs of the bridge deck. Furthermore, the most unfavorable wind attack angle is 5o. At this attack angle and low damping ratios, the VIVs of the bridge deck are significant and much larger than the allowable value. In addition, the VIVs of the bridge deck decrease with increasing the damping ratios (Particularly, at large damping ratios, the VIVs were well suppressed). This study provides a guideline for the designs of long span flexible bridges on suppressing the VIVs of the bridges.
Design optimization and development of SMC composite tray
Cun-fei Wang,Zeng-fu Yang,Chengwang Shi,Xiaodong Li,Xu-feng Zhang 한양대학교 청정에너지연구소 2024 Journal of Ceramic Processing Research Vol.25 No.2
In the engineering application, trays are easy to break down to result in anchorage failure in the composite anchoring systems. Therefore, the research carried out the force analysis with mechanics of materials to observe the main stress concentration anddeformation of the tray. From the findings of the force analysis, the structure and key parameters of the tray were optimizedwith reference of the existing tray design. Besides, the study turns to the finite element software to simulate and analyze thetray. The results manifest that tray failure during the support mainly results from the expansion and deformation of the taperhole squeezed by the nut, which causes the tray taper hole to rupture and crackle extend, thus leading to its crack. What’smore, the tray breaks for the compression of the tray edge by the surrounding rock. The maximum deformation at the largeend of the optimized tray tapered hole was reduced from 33.8 mm to 4.7 mm, approximately 86% with the shear stress reducedfrom 781.67 Mpa to 258.83 Mpa, about 66.8%. Using Sheet Molding Compound (SMC) to mould trays with new structure andconducting the test of tray bearing capacity, it can be found that its bearing capacity is up to 250 KN. After the taper hole ofthe tray is locally strengthened, its bearing capacity is increased to 304 KN.
Shi, Liang,Wu, Li-Li,Yang, Jian-Rong,Chen, Xiao-Fei,Zhang, Yi,Chen, Zeng-Qiang,Liu, Cun-Li,Chi, Sheng-Ying,Zheng, Jia-Ying,Huang, Hai-Xia,Yu, Fu-Jun,Lin, Xiang-Yang Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.7
Background: Recently, peroxiredoxin3 (PRDX3) was identified as a novel molecular marker for the progression of hepatocellular carcinoma (HCC). However, its potential clinical application as a serum marker for the early diagnosis and prognosis of HCC has not been investigated. Methods: PRDX3, alpha-fetaprotein (AFP), and other biochemical parameters were measured in serum samples from 297 Chinese patients, including 96 with HCC, 98 with liver cirrhosis (LC), and 103 healthy controls (HCs). Correlations between serum PRDX3 expression and clinicopathological variables and the relationship between serum PRDX3 expression and prognosis were analyzed. Results: Serum PRDX3 was significantly higher in HCC patients than in the LC and HC groups. The sensitivity and specificity of serum PRDX3 for the diagnosis of HCC were 85.9% and 75.3%, respectively, at a cutoff of 153.26 ng/mL, and the area under the curve was 0.865. Moreover, serum PRDX3 expression was strongly associated with AFP level, tumor diameter, TNM stage, and portal vein invasion. Kaplan-Meier curve analysis revealed that HCC patients with high serum PRDX3 expression had a shorter median survival time than those with low PRDX3 expression. Moreover, serum PRDX3 expression was an independent risk factor for overall survival. The inverse correlation between serum PRDX3 and patient survival remained significant in patients with early-stage HCC and in those with normal serum AFP levels. Conclusions: Serum PRDX3 can be used as a noninvasive biomarker for the diagnosis and/or prognosis of HCC.
Shi, Liang,Chen, Zhan-Guo,Wu, Li-li,Zheng, Jian-Jian,Yang, Jian-Rong,Chen, Xiao-Fei,Chen, Zeng-Qiang,Liu, Cun-Li,Chi, Sheng-Ying,Zheng, Jia-Ying,Huang, Hai-Xia,Lin, Xiang-Yang,Zheng, Fang Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.23
Many chemotherapeutic agents have been successfully used to treat hepatocellular carcinoma (HCC); however, the development of chemoresistance in liver cancer cells usually results in a relapse and worsening of prognosis. It has been demonstrated that DNA methylation and histone modification play crucial roles in chemotherapy resistance. Currently, extensive research has shown that there is another potential mechanism of gene expression control, which is mediated through the function of short noncoding RNAs, especially for microRNAs (miRNAs), but little is known about their roles in cancer cell drug resistance. In present study, by taking advantage of miRNA effects on the resistance of human hepatocellular carcinoma cells line to cisplatin, it has been demonstrated that miR-340 were significantly downregulated whereas Nrf2 was upregulated in HepG2/CDDP (cisplatin) cells, compared with parental HepG2 cells. Bioinformatics analysis and luciferase assays of Nrf2-3'-untranslated region-based reporter constructor indicated that Nrf2 was the direct target gene of miR-340, miR-340 mimics suppressing Nrf2-dependent antioxidant pathway and enhancing the sensitivity of HepG2/CDDP cells to cisplatin. Interestingly, transfection with miR-340 mimics combined with miR-340 inhibitors reactivated the Nrf2 related pathway and restored the resistance of HepG2/CDDP cells to CDDP. Collectively, the results first suggested that lower expression of miR-340 is involved in the development of CDDP resistance in hepatocellular carcinoma cell line, at least partly due to regulating Nrf2-dependent antioxidant pathway.