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Cui, Jing-Hao,Cao, Qing-Ri,Lee, Beom-Jin Informa Healthcare 2007 DRUG DELIVERY Vol.14 No.5
<P> Enhanced delivery of bifidobacteria and fecal changes were compared following multiple oral administrations of protected bifidobacteria-loaded alginate poly-l-lysine microparticles (bap-microparticles) and unprotected bifidobacteria cultures over a period of 1 month to healthy human volunteers as preliminary in vivo studies. When bap-microparticles were orally administered, enhanced delivery of bifidobacteria was achieved. The viability of the bifidobacteria was significantly increased ∼ 11.5-30 times (1.06-1.48 log cycles) during the ingestion period when compared with the bifidobacteria culture group (p < 0.05). However, other gut microflora such as bifidobacteria, enterobacteriaceae, lactic acid bacteria, and staphylococci in feces were not significantly different between the two groups. Encapsulated bifidobacteria resulted in more frequent defecation and decreased fecal viscosity.</P>
Cui, Jing-Hao,Cao, Qing-Ri,Choi, Yun-Jaie,Lee, Kyung-Hoon,Lee, Beom-Jin The Pharmaceutical Society of Korea 2006 Archives of Pharmacal Research Vol.29 No.8
Bifidobacteria-loaded alginate poly-l-lysine microparticles (bap microparticles) were prepared using an air atomization method and then freeze-dried. The viability of the bap microparticles was investigated as a function of the amount of the bifidobacteria cultures, and the addition of a yeast extract, cryoprotectants, antioxidants and neutralizer. The size of the bap microparticles with and without the bifidobacteria was $84.8{\pm}28.5\;{\mu}m$ ($mean{\pm}standard$ deviation) and $113.1{\pm}38.5\;{\mu}m$, respectively. The surface morphology was slightly ellipsoid and wrinkled regardless of the incorporating bifidobacteria. The viability gradually decreased with increasing freeze-drying time. Free-flowing powdered bap microparticles were obtained at least 12 h after freeze-drying the wetted slurry of bap microparticles. However, the particles tended to aggregate when either lactose or ascorbic acid was added. The addition of a yeast extract, cryoprotectants (glycerol and lactose), antioxidants ($NaHSO_3$ and ascorbic acid) and neutralizer $(Mg_3(PO_4)_2)$ resulted in a significantly higher viability of the bifidobacteria in the bap microparticles after freeze-drying (0.34-1.84 log) compared with the culture alone.
Cui, Jing,Shen, Liang,Wang, Yu Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.10
Background: The Cyclin D1(CCND1) G870A polymorphism may be associated with breast cancer, but the evidence from individual studies is inconclusive. The aim of this study was to investigate the correlation between the CCND1 G870A polymorphism and breast cancer risk in a meta-analysis. Materials and Methods: We searched Pubmed and analysed 11 articles on 5,528 cases and 5,353 controls before February 1, 2012. Results: we found there are significant association for AA versus GG and AA versus GA/GG. No significant associations were found for GA versus GG, GA/AA versus GG. There are significant association for AA versus GG, and AA versus GA/GG in Caucasians. We didn't find any significant main effects for G870A polymorphism on breast cancer risk either in recessive or dominant models in Asians. Conclusion: This meta-analysis suggests that AA of the CCND1 G870A polymorphism is associated with breast cancer susceptibility.
Nonlocal Cauchy problem for some stochastic integro-differential equations in Hilbert spaces
Jing Cui,Litan Yan,Xiaotai Wua 한국통계학회 2012 Journal of the Korean Statistical Society Vol.41 No.3
In this paper, we study the existence results of mild solutions for a class of stochastic integro-differential equations with nonlocal conditions and stochastic impulsive integrodifferential equations with nonlocal conditions in Hilbert spaces. Sufficient conditions for the existence of mild solutions are derived by means of Leray–Schauder nonlinear alternative. An example is provided to illustrate the theory.
Nonlocal Cauchy problem for some stochastic integro-differential equations in Hilbert spaces
Cui, Jing,Yan, Litan,Wu, Xiaotai 한국통계학회 2012 Journal of the Korean Statistical Society Vol.41 No.3
In this paper, we study the existence results of mild solutions for a class of stochastic integro-differential equations with nonlocal conditions and stochastic impulsive integro-differential equations with nonlocal conditions in Hilbert spaces. Sufficient conditions for the existence of mild solutions are derived by means of Leray-Schauder nonlinear alternative. An example is provided to illustrate the theory.
Jing-Hao Cui,Qing-Ri Cao,Yun-Jaie Choi,Kyung-Hoon Lee,이범진 대한약학회 2006 Archives of Pharmacal Research Vol.29 No.8
Bifidobacteria-loaded alginate poly-l-lysine microparticles (bap microparticles) were prepared using an air atomization method and then freeze-dried. The viability of the bap microparticles was investigated as a function of the amount of the bifidobacteria cultures, and the addition of a yeast extract, cryoprotectants, antioxidants and neutralizer. The size of the bap microparticles with and without the bifidobacteria was 84.8±28.5 μm (mean±standard deviation) and 113.1±38.5 μm, respectively. The surface morphology was slightly ellipsoid and wrinkled regardless of the incorporating bifidobacteria. The viability gradually decreased with increasing freeze-drying time. Free-flowing powdered bap microparticles were obtained at least 12 h after freeze-drying the wetted slurry of bap microparticles. However, the particles tended to aggregate when either lactose or ascorbic acid was added. The addition of a yeast extract, cryoprotectants (glycerol and lactose), antioxidants (NaHSO3 and ascorbic acid) and neutralizer (Mg3(PO4)2) resulted in a significantly higher viability of the bifidobacteria in the bap microparticles after freeze-drying (0.34-1.84 log) compared with the culture alone.