http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Corté,s, M.L.,Rodriguez, W.,Doornenbal, P.,Obertelli, A.,Holt, J.D.,Lenzi, S.M.,Mené,ndez, J.,Nowacki, F.,Ogata, K.,Poves, A.,Rodrí,guez, T.R.,Schwenk, A.,Simonis, J.,Stroberg, S.R. North-Holland Pub. Co 2020 Physics letters. Section B Vol.800 No.-
<P><B>Abstract</B></P> <P>Excited states in the N = 40 isotone <SUP>62</SUP>Ti were populated via the <SUP>63</SUP>V ( p , 2 p ) <SUP>62</SUP>Ti reaction at ∼200 MeV/nucleon at the Radioactive Isotope Beam Factory and studied using <I>γ</I>-ray spectroscopy. The energies of the 2 1 + → 0 gs + and 4 1 + → 2 1 + transitions, observed here for the first time, indicate a deformed <SUP>62</SUP>Ti ground state. These energies are increased compared to the neighboring <SUP>64</SUP>Cr and <SUP>66</SUP>Fe isotones, suggesting a small decrease of quadrupole collectivity. The present measurement is well reproduced by large-scale shell-model calculations based on effective interactions, while ab initio and beyond mean-field calculations do not yet reproduce our findings. The shell-model calculations for <SUP>62</SUP>Ti show a dominant configuration with four neutrons excited across the N = 40 gap. Likewise, they indicate that the N = 40 island of inversion extends down to Z = 20 , disfavoring a possible doubly magic character of the elusive <SUP>60</SUP>Ca.</P>
Rugo, Hope S.,Tré,dan, Olivier,Ro, Jungsil,Morales, Serafin M.,Campone, Mario,Musolino, Antonino,Afonso, Noé,mia,Ferreira, Marta,Park, Kyong Hwa,Cortes, Javier,Tan, Antoinette R.,Blum, Joa Springer-Verlag 2017 Breast cancer research and treatment Vol.165 No.3
<P>R/D/E did not improve PFS compared with R/E. Because the PFS reported for R/E was similar to that reported for everolimus plus exemestane in patients with advanced breast cancer, it is possible that lower-dose ridaforolimus in the R/D/E arm (from overlapping toxicities with IGF1R inhibitor) contributed to lack of improved PFS.</P>
Yon, Felipe,Kessler, Danny,Joo, Youngsung,Corté,s Llorca, Lucas,Kim, Sang-Gyu,Baldwin, Ian T. Wiley (Blackwell Publishing) 2017 Journal of integrative plant biology Vol.59 No.3
<P>Ecological interactions between flowers and pollinators are all about timing. Flower opening/closing and scent emissions are largely synchronized with pollinator activity, and a circadian clock regulates these rhythms. However, whether the circadian clock increases a plant's reproductive success by regulating these floral rhythms remains untested. Flowers of Nicotiana attenuata, a wild tobacco, diurnally and rhythmically open, emit scent and move vertically through a 140 degrees arc to interact with nocturnal hawkmoths. We tethered flowers to evaluate the importance of flower positions for Manduca sexta-mediated pollinations; flower position dramatically influenced pollination. We examined the pollination success of phase-shifted flowers, silenced in circadian clock genes, NaZTL, NaLHY, and NaTOC1, by RNAi. Circadian rhythms in N. attenuata flowers are responsible for altered seed set from outcrossed pollen.</P>
Jabbour, Elias,Kantarjian, Hagop M.,Saglio, Giuseppe,Steegmann, Juan Luis,Shah, Neil P.,Boqué,, Concepció,n,Chuah, Charles,Pavlovsky, Carolina,Mayer, Jiř,í,Cortes, Jorge,Baccara American Society of Hematology 2014 Blood Vol.123 No.4
<P>This analysis explores the impact of early cytogenetic and molecular responses on the outcomes of patients with chronic myeloid leukemia in chronic phase (CML-CP) in the phase 3 DASatinib versus Imatinib Study In treatment-Naive CML patients trial with a minimum follow-up of 3 years. Patients with newly diagnosed CML-CP were randomized to receive 100 mg dasatinib (n = 259) or 400 mg imatinib (n = 260) once daily. The retrospective landmark analysis included patients evaluable at the relevant time point (3, 6, or 12 months). Median time to complete cytogenetic response was 3 vs 6 months with dasatinib vs imatinib. At 3 and 6 months, the proportion of patients with BCR-ABL transcript levels ≤10% was higher in the dasatinib arm. Deeper responses at 3, 6, and 12 months were observed in a higher proportion of patients on dasatinib therapy and were associated with better 3-year progression-free survival and overall survival in both arms. First-line dasatinib resulted in faster and deeper responses compared with imatinib. The achievement of an early molecular response was predictive of improved progression-free survival and overall survival, supporting new milestones for optimal response in patients with early CML-CP treated with tyrosine kinase inhibitors. This study was registered at www.clinicaltrials.gov as NCT00481247.</P>
Perspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics
Ding, Li,Bailey, Matthew H.,Porta-Pardo, Eduard,Thorsson, Vesteinn,Colaprico, Antonio,Bertrand, Denis,Gibbs, David L.,Weerasinghe, Amila,Huang, Kuan-lin,Tokheim, Collin,Corté,s-Ciriano, Isidro,J Elsevier 2018 Cell Vol.173 No.2
<P><B>Summary</B></P> <P>The Cancer Genome Atlas (TCGA) has catalyzed systematic characterization of diverse genomic alterations underlying human cancers. At this historic junction marking the completion of genomic characterization of over 11,000 tumors from 33 cancer types, we present our current understanding of the molecular processes governing oncogenesis. We illustrate our insights into cancer through synthesis of the findings of the TCGA PanCancer Atlas project on three facets of oncogenesis: (1) somatic driver mutations, germline pathogenic variants, and their interactions in the tumor; (2) the influence of the tumor genome and epigenome on transcriptome and proteome; and (3) the relationship between tumor and the microenvironment, including implications for drugs targeting driver events and immunotherapies. These results will anchor future characterization of rare and common tumor types, primary and relapsed tumors, and cancers across ancestry groups and will guide the deployment of clinical genomic sequencing.</P> <P><B>Highlights</B></P> <P> <UL> <LI> An overview of PanCancer Atlas analyses on oncogenic molecular processes </LI> <LI> Germline genome affects somatic genomic landscape in a pathway-dependent fashion </LI> <LI> Genome mutations impact expression, signaling, and multi-omic profiles </LI> <LI> Mutation burdens and drivers influence immune-cell composition in microenvironment </LI> </UL> </P> <P><B>Graphical Abstract</B></P> <P>[DISPLAY OMISSION]</P>