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Thomas Michlmayr,Andreas Fognini,Thomas B¨ahler,Gerard Salvatella Orgill´es,Christoph Wetli,Andreas Vaterlaus,Yves Acremann 한국물리학회 2013 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.62 No.12
We report on the design and tests of a completely mobile photoemission end station for femtosecondtime, energy and spin resolved magnetodynamics experiments. The setup is designed forthe use at free-electron laser (FEL) x-ray beamlines as well as at synchrotron facilities. In situsample preparation in an adjacent UHV chamber is performed. The assembly can be altered toobtain energy resolved measurements with the help of a hemispherical electron energy analyzeror to obtain energy integrated measurements by inserting an electron transfer lens system. Themagnetic information is obtained by spin analysis with a 50 kV Mott detector. The setup is testedin house with an electron gun, at the Swiss Light Source (SLS) and has been used at the FEL atFLASH in Hamburg. Results show the practicability of the system and exemplarily the kineticenergy dependent polarization of the low energy secondary electrons emitted from a 15 ML ironfilm on W(110) is presented.
Thomas, Karen C,Ethirajan, Manivannan,Shahrokh, Kiumars,Sun, Hao,Lee, Jeewoo,Cheatham, Thomas E,Yost, Garold S,Reilly, Christopher A Williams Wilkins 2011 The Journal of pharmacology and experimental thera Vol.337 No.2
<P>Activation of intracellular transient receptor potential vanilloid-1 (TRPV1) in human lung cells causes endoplasmic reticulum (ER) stress, increased expression of proapoptotic GADD153 (growth arrest- and DNA damage-inducible transcript 3), and cytotoxicity. However, in cells with low TRPV1 expression, cell death is not inhibited by TRPV1 antagonists, despite preventing GADD153 induction. In this study, chemical variants of the capsaicin analog nonivamide were synthesized and used to probe the relationship between TRPV1 receptor binding, ER calcium release, GADD153 expression, and cell death in TRPV1-overexpressing BEAS-2B, normal BEAS-2B, and primary normal human bronchial epithelial lung cells. Modification of the 3-methoxy-4-hydroxybenzylamide vanilloid ring pharmacophore of nonivamide reduced the potency of the analogs and rendered several analogs mildly inhibitory. Correlation analysis of analog-induced calcium flux, GADD153 induction, and cytotoxicity revealed a direct relationship for all three endpoints in all three lung cell types for nonivamide and N-(3,4-dihydroxybenzyl)nonanamide. However, the N-(3,4-dihydroxybenzyl)nonanamide analog also produced cytotoxicity through redox cycling/reactive oxygen species formation, shown by inhibition of cell death by N-acetylcysteine. Molecular modeling of binding interactions between the analogs and TRPV1 agreed with data for reduced potency of the analogs, and only nonivamide was predicted to form a 'productive' ligand-receptor complex. This study provides vital information on the molecular interactions of capsaicinoids with TRPV1 and substantiates TRPV1-mediated ER stress as a conserved mechanism of lung cell death by prototypical TRPV1 agonists.</P>
Christopher Thomas Plastaras,Seth Schran,Joseph Constantino 셀메드 세포교정의약학회 2014 TANG Vol.4 No.4
Neck pain is an extremely common symptom with a variety of potential etiologies. A significant number of patients are turning to complementary and alternative medicine therapies. In particular, chiropractic and osteopathic manipulation techniques are discussed. “Low quality evidence”, as per the GRADE system criteria used by the Cochrane Review, supports the beneficial effects of these treatments Complications are generally benign and self-limited although occasional catastrophic consequences have been documented. Medical practitioners should familiarize themselves and their patients with the risks and benefits of complementary and alternative medicine in order to make informed decisions.
Adaptive Smith Predictor for Teleoperation of UAVs with Time-varying Internet Delay
Christopher Thomas,Sun Yi,Shava Meadows,Ryan Sherrill 제어·로봇·시스템학회 2020 International Journal of Control, Automation, and Vol.18 No.6
Time delay in a networked control system can negatively impact the performance of the system. Dynamic networks with unknown and varying latency such as the Internet are studied. Also, experiments with teleoperation of drones and communication loops through the Internet are conducted. Smith Predictors are well known for their ability to handle time delay. Smith Predictor controllers perform well when modeled accurately and when the delay is known. The proposed method combines a delay estimation technique based on characteristic roots of delay differential equations to measure the delay with an Adaptive Smith Predictor. When the delay parameter is adjusted correctly, the negative effects caused by delay are significantly reduced. The proposed method performs satisfactory for networked systems with unknown delay and the results are validated through simulations and experimentation.
디지털 시대에 EFL의 쓰기 - L2를 쓰는 사람들을 돕기 위한 기술적 전략에 관한 논의
( Christopher Thomas Linville ) 숭실대학교 인문과학연구소 2010 인문학연구 Vol.40 No.-
기술을 주변화 시키거나 전혀 사용하지 않는 구식의 교육 방식을 고수하는 언어 교육자들이 여전히 많은 가운데, 수업 중에 기술을 사용하는 것이 더 긍정적인 분위기를 만들고 학생들에게 동기를 부여하며 수단과 모델을 단순화시킴으로써 L2 학습자를 돕는다는 연구가 늘고 있다. 기술은 특별히 읽기, 쓰기, 말하기와 듣기라는 네 영역의 언어 획득 영역을 연관시켜 발전시키는데 효율적이라는 사실 또한 발견되었다. 이 논문의 초점은 EFL 수업에서 쓰기 능력을 돕기 위한 기술적인 다양한 전략에 대해 소개하는데 있다. While there are still many language educators that hold onto the old ways of teaching in which technology is sidelined or barely used at all, growing research suggests that using technology in the classroom creates a more positive atmosphere, engages and motivates students, and helps L2 learners by simplifying methods and models. Specifically, technology has also been found to be very useful in engaging and improving all four areas of language acquisition: reading, writing, speaking, and listening. The focus of this paper is to present various technological strategies to aid writing ability in the EFL classroom.
Primiani Christopher Thomas,Husari Khalil Salim,Mathur Rohan,Geocadin Romergryko Guance 대한신경집중치료학회 2022 대한신경집중치료학회지 Vol.15 No.2
Background: Fixed and dilated pupils (FDPs) have become synonymous with devastating neurological damage and brainstem injury commonly associated with mass effect and herniation. Infrequently, changes in pupillary light response have been described with seizures; however, the loss of pupillary response with documented Neurological Pupil index has not been well established in patients with seizures.Case Report: We present a case report describing a middle-aged female patient with focal status epilepticus with intermittent FDPs. An abnormal pupillary response occurred with right hemispheric lateralized periodic discharges and resolution with anti-seizure medication escalation. To our knowledge, this is the first description of objective documentation of reversible FDP as a possible clinical correlate of lateralized periodic discharges. Conclusion: The use of handheld automated pupillometry in conjunction with electroencephalogram (EEG) has provided the therapeutic direction. Further research is warranted to fully describe the mechanistic underpinnings of these observations.
Thomas, Karen C,Roberts, Jessica K,Deering-Rice, Cassandra E,Romero, Erin G,Dull, Randal O,Lee, Jeewoo,Yost, Garold S,Reilly, Christopher A American Physiological Society 2012 American journal of physiology. Lung cellular and Vol.302 No.1
<P>Endogenous agonists of transient receptor potential vanilloid-1 (TRPV1) (endovanilloids) are implicated as mediators of lung injury during inflammation. This study tested the hypothesis that endovanilloids produced following lipopolysaccharide (LPS) treatment activate TRPV1 and cause endoplasmic reticulum stress/GADD153 expression in lung cells, representing a mechanistic component of lung injury. The TRPV1 agonist nonivamide induced GADD153 expression and caused cytotoxicity in immortalized and primary human bronchial, bronchiolar/alveolar, and microvascular endothelial cells, proportional to TRPV1 mRNA expression. In CF-1 mice, Trpv1 mRNA was most abundant in the alveoli, and intratracheal nonivamide treatment promoted Gadd153 expression in the alveolar region. Treatment of CF-1 mice with LPS increased Gadd153 in the lung, lactate dehydrogenase (LDH) in bronchoalveolar lavage (BAL) fluid, and lung wet-to-dry weight ratio. Cotreating mice with LPS and the TRPV1 antagonist LJO-328 reduced Gadd153 induction and LDH in BAL but did not inhibit increases in lung wet-to-dry ratio. In Trpv1(-/-) mice treated with LPS, Gadd153 induction and LDH in BAL were reduced relative to wild-type mice, and the wet-to-dry weight ratios of lungs from both wild-type and Trpv1(-/-) mice decreased. Organic extracts of blood collected from LPS-treated mice were more cytotoxic to TRPV1-overexpressing cells compared with BEAS-2B cells and extracts from control mice, however, most pure endovanilloids did not produce cytotoxicity in a characteristic TRPV1-dependent manner. Collectively, these data indicate a role for TRPV1, and endogenous TRPV1 agonists, in ER stress and cytotoxicity in lung cells but demonstrate that ER stress and cytotoxicity are not essential for pulmonary edema.</P>
Neuropeptide Regulation of Signaling and Behavior in the BNST
Thomas L. Kash,Kristen E. Pleil,Catherine A. Marcinkiewcz,Emily G. Lowery-Gionta,Nicole Crowley,Christopher Mazzone,Jonathan Sugam,J. Andrew Hardaway,Zoe A. McElligott 한국분자세포생물학회 2015 Molecules and cells Vol.38 No.1
Recent technical developments have transformed how neuroscientists can probe brain function. What was once thought to be difficult and perhaps impossible, stimulating a single set of long range inputs among many, is now relatively straight-forward using optogenetic approaches. This has provided an avalanche of data demonstrating causal roles for circuits in a variety of behaviors. However, despite the critical role that neuropeptide signaling plays in the regulation of behavior and physiology of the brain, there have been remarkably few studies demonstrating how peptide release is causally linked to behaviors. This is likely due to both the different time scale by which peptides act on and the modulatory nature of their actions. For example, while glutamate release can effectively transmit information between synapses in milliseconds, peptide release is potentially slower [See the excellent review by Van Den Pol on the time scales and mechanisms of release (van den Pol, 2012)] and it can only tune the existing signals via modulation. And while there have been some studies exploring mechanisms of release, it is still not as clearly known what is required for efficient peptide release. Furthermore, this analysis could be complicated by the fact that there are multiple peptides released, some of which may act in contrast. Despite these limitations, there are a number of groups making progress in this area. The goal of this review is to explore the role of peptide signaling in one specific structure, the bed nucleus of the stria terminalis, that has proven to be a fertile ground for peptide action.