http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Chowdhury Mobaswar Hossain (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
-
Imon Chakraborty,Chowdhury Mobaswar Hossain,Piyali Basak 대한의용생체공학회 2021 Biomedical Engineering Letters (BMEL) Vol.11 No.1
Hypopharyngeal tissue engineering is increasing rapidly in this developing world. Tissue damage or loss needs the replacementby another biological or synthesized membrane using tissue engineering. Tissue engineering research is emergingto provide an effective solution for damaged tissue replacement. Polyurethane in tissue engineering has successfully beenused to repair and restore the function of damaged tissues. In this context, Can polyurethane be a useful material to dealwith hypopharyngeal tissue defects? To explore this, here ester diol based polyurethane (PU) was synthesized in two steps:firstly, polyethylene glycol 400 (PEG 400) was reacted with lactic acid to prepare ester diol, and then it was polymerizedwith hexamethylene diisocyanate. The physical, mechanical, and biological testing was done to testify the characterizationof the membrane. The morphology of the synthesized membrane was investigated by using field emission scanning electronmicroscopy. Functional groups of the obtained membrane were characterized by fourier transform infrared spectroscopyspectroscopy. Several tests were performed to check the in vitro and in vivo biocompatibility of the membrane. A highlyconnected homogeneous network was obtained due to the appropriate orientation of a hard segment and soft segment in thesynthesized membrane. Mechanical property analysis indicates the membrane has a strength of 5.15 MPa and strain 124%. The membrane showed high hemocompatibility, no cytotoxicity on peripheral blood mononuclear cell, and susceptible todegradation in simulated body fluid solution. Antimicrobial activity assessment has shown promising results against clinicallysignificant bacteria. Primary hypopharyngeal cell growth on the PU membrane revealed the cytocompatibility andsubcutaneous implantation on the back of Wistar rats were given in vivo biocompatibility of the membrane. Therefore, thesynthesized material can be considered as a potential candidate for a hypopharyngeal tissue engineering application.
-
Raja Majumder,Lopamudra Adhikari,Chowdhury Mobaswar Hossain,Moonmun Dhara,Jinamitra Sahu 경희대학교 융합한의과학연구소 2020 Oriental Pharmacy and Experimental Medicine Vol.20 No.3
Olax psittacorum (Lam.) Vahl. has versatile ethnopharmacological healing property in addition with incomplete research are adequate pieces of information to support the choice of the plant to build up proper data in acute and sub-chronic toxicological, cytotoxicity with ex vivo and in vivo antioxidant profile as well as qualitative analytical illustration through GC–MS of the selected extracts obtained from different parts of the plant. We have extracted leaf methanolic extract (LME), stem methanolic extract (SME), stem aqueous extract (SAE) and fruits aqueous extract (FrAE) for the above mentioned respective studies. OECD guideline 420 and 407, brine shrimp lethality (BSLA), lipid peroxidation, catalase assay was conducted to gather information on toxicity, cytotoxicity, and antioxidant properties respectively. BSLA study indicates that LME may be a good choice to develop as an anticancer drug for future perspective ( LC50 = 41.88 μg/ml). Both LME and SME have been selected for ex vivo and in vivo antioxidant analysis on the basis of their low toxicity and GCMS analysis. Moreover, in vivo lipidperoxidation as well as catalase assay both having significant difference (P < 0.05) between the groups except LME 200 and positive control (P = 0.084) as well as LME 200 and SME 100 (P = 0.054) respectively. This study justifies that high dose exposure of FrAE, SAE, and SME could be so toxic due to changes in biochemical parameters and in comparison, LME is safer according to the significant (P < 0.05) outcome statistically. LME and SME are safe to consume at a dose of ≤ 200 mg/kg/bw as herbal supplements with antioxidant property.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
