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The in vivo photothermal treatment of gold nanorod in the mouse ear model
Liu, Bruce Yao Wen,Chen, Cheng-Lung,Lee, Shin-Yu,Chang, Fu-Hsiung,Lin, Win-Li,Chia, Chih-Ta,Chen, Yang-Yuan Techno-Press 2014 Biomaterials and biomedical engineering Vol.1 No.1
Gold nanorod's exceptional light to heat transduction is a robust phonomenon that has been extensively verified. The phenomenon is a trait from which many novel applications across disciplines have been proposed. In this investigation, the feasibility of utilizing heat harvested from such photothermal method to combat cancer is presented. Using non-invasive laser methods, an in vivo study is conducted on mouse ear tumors administered with gold nanorods (Au NRs). An emphasis is placed on monitoring the tumor developments after photothermal treatments, over time. The findings reveal significant tumor growth surpression at a threshold laser power of $0.6W/cm^2$ lasting 2 minutes; this energy also brought about dramatic size reduction in treated tumors. Furthermore, the apparent formation of an eschar over the laser treated region indicates extensive hemorrhagic necrosis of the tumor tissue; a phenomenon implicative to the inhibition of angiogenesis.
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The in vivo photothermal treatment of gold nanorod in the mouse ear model
Liu, Bruce Yao Wen,Chen, Cheng-Lung,Lee, Shin-Yu,Chang, Fu-Hsiung,Lin, Win-Li,Chia, Chih-Ta,Chen, Yang-Yuan Techno-Press 2014 Biomaterials and Biomechanics in Bioengineering Vol.1 No.1
Gold nanorod's exceptional light to heat transduction is a robust phonomenon that has been extensively verified. The phenomenon is a trait from which many novel applications across disciplines have been proposed. In this investigation, the feasibility of utilizing heat harvested from such photothermal method to combat cancer is presented. Using non-invasive laser methods, an in vivo study is conducted on mouse ear tumors administered with gold nanorods (Au NRs). An emphasis is placed on monitoring the tumor developments after photothermal treatments, over time. The findings reveal significant tumor growth surpression at a threshold laser power of $0.6W/cm^2$ lasting 2 minutes; this energy also brought about dramatic size reduction in treated tumors. Furthermore, the apparent formation of an eschar over the laser treated region indicates extensive hemorrhagic necrosis of the tumor tissue; a phenomenon implicative to the inhibition of angiogenesis.
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Chi-Chu Tsai,Chiou-Rong Sheue,Chih-Hsiung Chen,Chang-Hung Chou 한국식물학회 2010 Journal of Plant Biology Vol.53 No.6
The Phalaenopsis violacea complex includes two species: P. violacea Witte and Phalaenopsis bellina (Rchb.f.) E. A. Christ. However, three forms of P. violacea have been found in different areas, including Sumatra, the Malay Peninsula, and Mentawai Island. The phylogenetic tree inferred from the internal transcribed spacer (ITS)region of nuclear ribosomal DNA (nrDNA), the trnL intron,and the atpB-rbcL spacer of plastid DNA were used to clarify the phylogenetics and biogeography of the P. violacea complex. Analyses of the trnL intron sequences and of the atpB-rbcL spacer did not allow for apparent discrimination among these three species of the P. violacea complex. Based on the phylogenetic tree inferred from the ITS sequence, P. bellina cannot be separated from populations of P. violacea, with the exception of the population distributed on Mentawai Is., Indonesia. Based on morphological characteristics, P. violacea distributed on Mentawai Is. has a long and roundish rachis and is separate from the other groups of the P. violacea complex described by Christenson (Timber, Portland, OR, 2001). Therefore,the results of this study show a trend that supports the conclusion that the population of the P. violacea complex on Mentawai Is. is a separate species from P. violacea. Based on the biogeography of the P. violacea complex,Mentawai plants of this complex might be descended from those on the Sumatra/Malay Peninsula.
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Tai, Cheng-Jeng,Pan, Chin-Kwun,Chen, Ching-Shyang,Hung, Chin-Sheng,Wu, Chih-Hsiung,Chiou, Hung-Yi Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.3
Objective: The optimal duration of adjuvant trastuzumab treatment in patients with HER2-positive breast cancer is not known. The aim of this study was to evaluate the efficacy of 6 months of adjuvant trastuzumab treatment in patients with stage II or III HER2-positive breast cancer. Methods: The records of patients with HER2-positive stage II or III breast cancer who were admitted to the Breast Center of Taipei Medical University Hospital and Yuan's General Hospital between 2000 and 2008 were reviewed. All patients received adjuvant trastuzumab at an initial dose of 4 mg/kg followed by a maintenance dose of 2 mg/kg/week for 22 weeks in combination with chemotherapy. Results: A total of 51 patients were included with a mean age of 46.9 years. Approximately 55% of the patients had stage III disease. The mean follow-up time from initiation of treatment was 45.2 months (range, 0.9 to 85 months). During follow-up, 46 patients (90.2%) did not experience tumor recurrence. The mean estimated disease free survival was 80.2 months. The estimated 1-, 2-, 5-, and 7-year survival rates were 97.9%, 93.1%, 93.1%, and 93.1%, respectively. The most common adverse effects were gastrointestinal symptoms (21.6%), chills (17.6%), dizziness (9.8%), and bone pain (7.8%). No cardiac or hematologic adverse events occurred. Conclusion: Adjuvant therapy with trastuzumab for 6 months resulted in a clinical benefit in patients with HER2-positive breast cancer.
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