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RISS 인기검색어
- 검색키워드
- 저자 : Chertok, M. (검색결과 3 건)
- 무료
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Chertok, Beata,David, Allan E.,Yang, Victor C. Elsevier 2011 Journal of controlled release Vol.155 No.3
<P><B>Abstract</B></P><P>Our previous studies demonstrated feasibility of magnetically-mediated retention of iron oxide nanoparticles in brain tumors after intravascular administration. The purpose of this study was to elucidate strategies for further improvement of this promising approach. In particular, we explored administration of the nanoparticles via a non-occluded carotid artery as a way to increase the passive exposure of tumor vasculature to nanoparticles for subsequent magnetic entrapment. However, aggregation of nanoparticles in the afferent vasculature interfered with tumor targeting. The magnetic setup employed in our experiments was found to generate a relatively uniform magnetic flux density over a broad range, exposing the region of the afferent vasculature to high magnetic force. To overcome this problem, the magnetic setup was modified with a 9-mm diameter cylindrical NdFeB magnet to exhibit steeper magnetic field topography. Six-fold reduction of the magnetic force at the injection site, achieved with this modification, alleviated the aggregation problem under the conditions of intact carotid blood flow. Using this setup, carotid administration was found to present 1.8-fold increase in nanoparticle accumulation in glioma compared to the intravenous route at 350mT. This increase was found to be in reasonable agreement with the theoretically estimated 1.9-fold advantage of carotid administration, <I>R</I><SUB><I>d</I></SUB>. The developed approach is expected to present an even greater advantage when applied to drug-loaded nanoparticles exhibiting higher values of <I>R</I><SUB><I>d</I></SUB>.</P> <P><B>Graphical abstract</B></P><P><ce:figure id='f0035'></ce:figure></P>
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David, A.E.,Cole, A.J.,Chertok, B.,Park, Y.S.,Yang, V.C. Elsevier Science Publishers 2011 Journal of controlled release Vol.152 No.1
Magnetic nanoparticles (MNP) continue to draw considerable attention as potential diagnostic and therapeutic tools in the fight against cancer. Although many interacting forces present themselves during magnetic targeting of MNP to tumors, most theoretical considerations of this process ignore all except for the magnetic and drag forces. Our validation of a simple in vitro model against in vivo data, and subsequent reproduction of the in vitro results with a theoretical model indicated that these two forces do indeed dominate the magnetic capture of MNP. However, because nanoparticles can be subject to aggregation, and large MNP experience an increased magnetic force, the effects of surface forces on MNP stability cannot be ignored. We accounted for the aggregating surface forces simply by measuring the size of MNP retained from flow by magnetic fields, and utilized this size in the mathematical model. This presumably accounted for all particle-particle interactions, including those between magnetic dipoles. Thus, our ''corrected'' mathematical model provided a reasonable estimate of not only fractional MNP retention, but also predicted the regions of accumulation in a simulated capillary. Furthermore, the model was also utilized to calculate the effects of MNP size and spatial location, relative to the magnet, on targeting of MNPs to tumors. This combination of an in vitro model with a theoretical model could potentially assist with parametric evaluations of magnetic targeting, and enable rapid enhancement and optimization of magnetic targeting methodologies.
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CDF run IIb silicon: design and testing
Lu, R.-S.,Akimoto, T.,Aoki, M.,Azzi, P.,Bacchetta, N.,Behari, S.,Benjamin, D.,Bisello, D.,Bolla, G.,Bortoletto, D.,Busetto, G.,Cabrera, S.,Canepa, A.,Cardoso, G.,Chertok, M.,Ciobanu, C.I.,Derylo, G.,F IEEE 2004 IEEE transactions on nuclear science Vol.51 No.5
<P>The various generations of Silicon Vertex Detectors (SVX, SVX', SVXII) for Collider Detector at Fermilab (CDF) at the Fermilab Tevatron have been fundamental tools for heavy-flavor tagging via secondary vertex detection. The CDF Run IIb Silicon Vertex Detector (SVXIIb) has been designed to be a radiation-tolerant replacement for the currently installed SVXII because SVXII was not expected to survive the Tevatron luminosity anticipated for Run IIb. One major change in the new design is the use of a single mechanical and electrical element throughout the array. This element, called a stave, carries six single-sided silicon sensors on each side and is built using carbon fiber skins with a high thermal conductivity on a foam core with a built-in cooling channel. A Kapton bus cable carries power, data and control signals underneath the silicon sensors on each side of the stave. Sensors are read out in pairs via a ceramic hybrid glued on one of the sensors and equipped with four SVX4 readout chips. This new design concept leads to a very compact mechanical and electrical unit, allowing streamlined production and ease of testing and installation. A description of the design and mechanical performance of the stave is given. Results on the electrical performance obtained using prototype staves are also presented.</P>
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