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- 저자 : Chen Jinzhi (검색결과 3 건)
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( Juan Chen ),( Zhenwen Qian ),( Fengling Li ),( Jinzhi Li ),( Yi Lu ) 대한소화기학회 2017 Gut and Liver Vol.11 No.1
Background/Aims: The integration of multiple profiling data and the construction of a transcriptional regulatory network may provide additional insights into the molecular mechanisms of hepatocellular carcinoma (HCC). The present study was conducted to investigate the deregulation of genes and the transcriptional regulatory network in HCC. Methods: An integrated analysis of HCC gene expression datasets was performed in Gene Expression Omnibus. Functional annotation of the differentially expression genes (DEGs) was conducted. Furthermore, transcription factors (TFs) were identified, and a global transcriptional regulatory network was constructed. Results: An integrated analysis of eight eligible gene expression profiles of HCC led to 1,835 DEGs. Consistent with the fact that the cell cycle is closely related to various tumors, the functional annotation revealed that genes involved in the cell cycle were significantly enriched. A transcriptional regulatory network was constructed using the 62 TFs, which consisted of 872 TF-target interactions between 56 TFs and 672 DEGs in the context of HCC. The top 10 TFs covering the most downstream DEGs were ZNF354C, NFATC2, ARID3A, BRCA1, ZNF263, FOXD1, GATA3, FOXO3, FOXL1, and NR4A2. This network will appeal to future investigators focusing on the development of HCC. Conclusions: The transcriptional regulatory network can provide additional information that is valuable in understanding the underlying molecular mechanism in hepatic tumorigenesis. (Gut Liver 2017;11:112-120)
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Zhou, Limin,Zhang, Kai,Sheng, Jinzhi,An, Qinyou,Tao, Zhanliang,Kang, Yong-Mook,Chen, Jun,Mai, Liqiang Elsevier 2017 Nano energy Vol.35 No.-
<P><B>Abstract</B></P> <P>Considering inherent large structural deterioration of conversion-type anode materials during repeated sodiation/desodiation process, the ingenious integration of both nanostructure engineering and chemical hybridization is highly desirable and challenging. Here, ultrafine CoS nanoparticles embedded in porous carbon nanorods (denoted as 7-CoS/C) were facilely fabricated via simultaneous in-situ carbonization and sulfidation of Co-metal organic frameworks (Co-MOF) and have been applied as anode materials for sodium-ion batteries (SIBs). Benefiting from the advantageous embedding architecture between the nanoparticles and porous nanorods, the 7-CoS/C delivers long-term cycling stability (542mAhg<SUP>−1</SUP> after 2000 cycles with a capacity retention of 91.4% at 1Ag<SUP>−1</SUP>) and excellent rate performance (discharge capacities of 510mAhg<SUP>−1</SUP> at 5Ag<SUP>−1</SUP> and 356mAhg<SUP>−1</SUP> even at 40Ag<SUP>−1</SUP>), which is proved to be characterized of partial pseudocapacitive behaviors during the sodiation/desodiation process. In addition, Na<SUB>3</SUB>V<SUB>2</SUB>(PO<SUB>4</SUB>)<SUB>3</SUB>/7-CoS/C full cell with excessive amount of Na<SUB>3</SUB>V<SUB>2</SUB>(PO<SUB>4</SUB>)<SUB>3</SUB> has been assembled and exhibits a capacity of 352mAhg<SUP>−1</SUP> at 0.5Ag<SUP>−1</SUP>. This meaningful approach can be extended to build embedded porous structure of other hybrid composites for next-generation energy-storage technology.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The embedded hybrid architecture of the 7-CoS/C is favorable for relieving volume expansion and immobilizing the CoS nanoparticles sites. </LI> <LI> The effect of different electrolyte on the 7-CoS/C/Na system was investigated. </LI> <LI> The variation of structure and valence in Na<SUP>+</SUP> insertion/extraction process of the 7-CoS/C is presented by <I>ex situ</I> XANES. </LI> <LI> The unique structural feature of the 7-CoS/C reveals obvious advantages at more than 1Ag<SUP>−1</SUP> compared with other anode materials. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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Dengue Virus 2 NS2B Targets MAVS and IKKε to Evade the Antiviral Innate Immune Response
Nie Ying,Deng Dongqing,Mou Lumin,Long Qizhou,Chen Jinzhi,Wu Jiahong 한국미생물·생명공학회 2023 Journal of microbiology and biotechnology Vol.33 No.5
Dengue virus (DENV) is a widespread arbovirus. To efficiently establish infection, DENV evolves multiple strategies to hijack the host innate immune response. Herein, we examined the inhibitory effects of DENV serotype 2 (DENV2) nonstructural proteins on RIG-I-directed antiviral immune response. We found that DENV2 NS2A, NS2B, NS4A, and NS4B significantly inhibited RIG-I-mediated IFN-β promoter activation. The roles of NS2B in RIG-I-directed antiviral immune response are unknown. Our study further showed that NS2B could dose-dependently suppress RIG-I/MAVSinduced activation of IFN-β promoter. Consistently, NS2B significantly decreased RIG-I- and MAVSinduced transcription of IFNB1, ISG15, and ISG56. Mechanistically, NS2B was found to interact with MAVS and IKKε to impair RIG-I-directed antiviral response. Our findings demonstrated a previously uncharacterized function of NS2B in RIG-I-mediated antiviral response, making it a promising drug target for anti-DENV treatments.
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