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Wang Fei,Luo Defan,Chen Jianxiang,Pan Cuiqing,Wang Zhongyao,Fu Housheng,Xu Jianbing,Yang Meng,Mo Shaowei,Zhuang Liying,Ye Liefu,Wang Weifu 대한남성과학회 2022 The World Journal of Men's Health Vol.40 No.2
Purpose: Genetic factors play an indispensable role in the pathogenesis of lifelong premature ejaculation (LPE). The suscep-tibility genes/SNPs that have been discovered are very limited and can only explain part of the genetic effects of LPE. There-fore, discovering more genetic polymorphisms associated with the occurrence and development of LPE will help reveal the pathogenesis of LPE. Materials Materials and and Methods:Methods: We conducted a genome-wide association study of LPE in 486 Chinese male Han people (cases and controls). We used Gene Titan multi-channel instrument and Axiom Analysis Suite 6.0 software for genotyping. Imputation was performed by IMPUTE2 software and the 1000 Genomes Project (Phase3) was used as reference for haplotype. Finally, logistic regression analysis was performed on all loci that passed the quality control. The odds ratio and 95% confidence in-terval were calculated to determine the association between each SNPs and Chinese male Han population LPE risk. Results:Results: The results showed that a total of 33 genetic variants in 13 genes (LACTBL1 , SSBP3 , ACOT11 , LINC02486 , TMEM154, LINC01098, NONE, HCG27, HLA-C, TNFSF8, TNC, FAM53B, SULF2) have a suggestively significant genome-wide association with LPE risk (p<5×10-6). Conclusions:Conclusions: This study is the first to conduct a GWAS on LPE in Chinese male Han population 33 genetic polymorphisms have a suggestive genome-wide association with LPE risk. This study have provided data supplement for the genetic loci of LPE risk, and laid a scientific foundation for the pathogenesis and the targeted therapy of LPE.
Le Wang,Qing Chen,Jianxiang Xi,Guangbin Liu 제어·로봇·시스템학회 2019 International Journal of Control, Automation, and Vol.17 No.5
The current paper studies the guaranteed-performance consensualization for general high-order multiagentsystems with intermittent communications. Firstly, a new consensus protocol is constructed by using only intermittentlocal information, and the corresponding performance function is given to guarantee the consensus regulationperformance among neighboring agents. Then, linear matrix inequality conditions for guaranteed-performanceconsensus and consensualization are respectively provided and a guaranteed-performance cost of multi-agent systemsis determined meanwhile. Furthermore, the whole motion mode of the multi-agent system can be described byderiving a precise expression of the consensus function. If the nominal converge rate is larger than a positive threshold,then multi-agent systems can achieve guaranteed-performance consensus by determining the gain matrix whenintermittent communications are involved, and the performance function is less than the guaranteed-performancecost. Finally, a simulation example is shown to demonstrate the effectiveness of the proposed theorems.
Exploring precise deposition and influence mechanism for micro-scale serpentine structure fiber
Wang, Han,Ou, Weicheng,Zhong, Huiyu,He, Jingfan,Wang, Zuyong,Cai, Nian,Chen, XinDu,Xue, Zengxi,Liao, Jianxiang,Zhan, Daohua,Yao, Jingsong,Wu, Peixuan Techno-Press 2022 Advances in nano research Vol.12 No.2
Micro-scale serpentine structure fibers are widely used as flexible sensor in the manufacturing of micro-nano flexible electronic devices because of their outstanding non-linear mechanical properties and organizational flexibility. The use of melt electrowriting (MEW) technology, combined with the axial bending effect of the Taylor cone jet in the process, can achieve the micro-scale serpentine structure fibers. Due to the interference of the process parameters, it is still challenging to achieve the precise deposition of micro-scale and high-consistency serpentine structure fibers. In this paper, the micro-scale serpentine structure fiber is produced by MEW combined with axial bending effect. Based on the controlled deposition of MEW, applied voltage, collector speed, nozzle height and nozzle diameter are adjusted to achieve the precise deposition of micro-scale serpentine structure fibers with different morphologies in a single motion dimension. Finally, the influence mechanism of the above four parameters on the precise deposition of micro-scale serpentine fibers is explored.