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From Ideology to Productivity: Reforming Early Childhood Education and Care in Australia
Sandra Cheeseman,Jane Torr 육아정책연구소 2009 International Journal of Child Care and Education Vol.3 No.1
Early childhood education and care services in Australia are undergoing major reforms, following widespread community concern about the quality of provision in general and the viability of corporate childcare in particular. A National Quality Framework has been developed by the current Australian Government to improve the quality, access and equity of early childhood services. As with any major social, political and economic change, however, the implementation of the reform agenda is subject to complex and often competing forces. In the paper, we describe the early childhood landscape in Australia today, and the possibilities and potential barriers to carrying out the much needed reforms proposed by the Australian Government. Early childhood professionals and the wider community are embracing the opportunity to work together to achieve a transformation in the way we educate and care for young children.
Using drawings and discussion to gain insights into young learners’ understanding of mass
Andrea McDonough,Jill Cheeseman 환태평양유아교육연구학회 2015 Asia-Pacific journal of research in early childhoo Vol.9 No.3
In this paper, we explore the possible value of an open-ended assessment task, Impress Me, and followup interview as ways to gain insights into children’s learning of mathematics,. Ten children in their first or second year of school recorded their understanding using drawing and/or writing after the period in which they were taught lessons on the measurement of mass. Later they met individually with an interviewer/researcher to discuss their drawing/writing and their learning. The Impress Me recording was found to be a useful prompt for the children to stimulate discussion about their learning.
The genome of the extremophile crucifer Thellungiella parvula
Dassanayake, Maheshi,Oh, Dong-Ha,Haas, Jeffrey S,Hernandez, Alvaro,Hong, Hyewon,Ali, Shahjahan,Yun, Dae-Jin,Bressan, Ray A,Zhu, Jian-Kang,Bohnert, Hans J,Cheeseman, John M Nature Publishing Group, a division of Macmillan P 2011 Nature genetics Vol.43 No.9
Thellungiella parvula is related to Arabidopsis thaliana and is endemic to saline, resource-poor habitats, making it a model for the evolution of plant adaptation to extreme environments. Here we present the draft genome for this extremophile species. Exclusively by next generation sequencing, we obtained the de novo assembled genome in 1,496 gap-free contigs, closely approximating the estimated genome size of 140 Mb. We anchored these contigs to seven pseudo chromosomes without the use of maps. We show that short reads can be assembled to a near-complete chromosome level for a eukaryotic species lacking prior genetic information. The sequence identifies a number of tandem duplications that, by the nature of the duplicated genes, suggest a possible basis for T. parvula's extremophile lifestyle. Our results provide essential background for developing genomically influenced testable hypotheses for the evolution of environmental stress tolerance.
EVI1 acts as an inducible negative-feedback regulator of NF-κB by inhibiting p65 acetylation.
Xu, Xiangbin,Woo, Chang-Hoon,Steere, Rachel R,Lee, Byung Cheol,Huang, Yuxian,Wu, Jing,Pang, Jinjiang,Lim, Jae Hyang,Xu, Haidong,Zhang, Wenhong,Konduru, Anuhya S,Yan, Chen,Cheeseman, Michael T,Brown, S Williams Wilkins 2012 JOURNAL OF IMMUNOLOGY Vol.188 No.12
<P>Inflammation is a hallmark of many important human diseases. Appropriate inflammation is critical for host defense; however, an overactive response is detrimental to the host. Thus, inflammation must be tightly regulated. The molecular mechanisms underlying the tight regulation of inflammation remain largely unknown. Ecotropic viral integration site 1 (EVI1), a proto-oncogene and zinc finger transcription factor, plays important roles in normal development and leukemogenesis. However, its role in regulating NF-κB-dependent inflammation remains unknown. In this article, we show that EVI1 negatively regulates nontypeable Haemophilus influenzae- and TNF-α-induced NF-κB-dependent inflammation in vitro and in vivo. EVI1 directly binds to the NF-κB p65 subunit and inhibits its acetylation at lysine 310, thereby inhibiting its DNA-binding activity. Moreover, expression of EVI1 itself is induced by nontypeable Haemophilus influenzae and TNF-α in an NF-κB-dependent manner, thereby unveiling a novel inducible negative feedback loop to tightly control NF-κB-dependent inflammation. Thus, our study provides important insights into the novel role for EVI1 in negatively regulating NF-κB-dependent inflammation, and it may also shed light on the future development of novel anti-inflammatory strategies.</P>