Genetic variant in TP63 on locus 3q28 is associated with risk of lung adenocarcinoma among never-smoking females in Asia

Hosgood III, H. Dean,Wang, Wen-Chang,Hong, Yun-Chul,Wang, Jiu-Cun,Chen, Kexin,Chang, I-Shou,Chen, Chien-Jen,Lu, Daru,Yin, Zhihua,Wu, Chen,Zheng, Wei,Qian, Biyun,Park, Jae Yong,Kim, Yeul Hong,Chatterje Springer-Verlag 2012 HUMAN GENETICS Vol.131 No.7

<P>A recent genome-wide association study (GWAS) of subjects from Japan and South Korea reported a novel association between the TP63 locus on chromosome 3q28 and risk of lung adenocarcinoma (p = 7.3 10(-12)); however, this association did not achieve genome-wide significance (p 10(-7)) among never-smoking males or females. To determine if this association with lung cancer risk is independent of tobacco use, we genotyped the TP63 SNPs reported by the previous GWAS (rs10937405 and rs4488809) in 3,467 never-smoking female lung cancer cases and 3,787 never-smoking female controls from 10 studies conducted in Taiwan, Mainland China, South Korea, and Singapore. Genetic variation in rs10937405 was associated with risk of lung adenocarcinoma [n = 2,529 cases; p = 7.1 10(-8); allelic risk = 0.80, 95% confidence interval (CI) = 0.74-0.87]. There was also evidence of association with squamous cell carcinoma of the lung (n = 302 cases; p = 0.037; allelic risk = 0.82, 95% CI = 0.67-0.99). Our findings provide strong evidence that genetic variation in TP63 is associated with the risk of lung adenocarcinoma among Asian females in the absence of tobacco smoking.</P>

III-nitride nanowires for solar light harvesting: A review

Chatterjee, U.,Park, Ji-Hyeon,Um, Dae-Young,Lee, Cheul-Ro PERGAMON 2017 RENEWABLE AND SUSTAINABLE ENERGY REVIEWS Vol.79 No.-

<P><B>Abstract</B></P> <P>The world needs economical and sustainable alternate energy sources to combat the irreversible phenomenon like global warming. Solar photovoltaic technology, which converts sunlight directly to electricity, is the most potential candidate for alternate energy source. On the other hand, increasing global pollution due to energy emission compels the worldwide researcher community to deliberate over various green fuels. Recently due to numerous advancements hydrogen fuel cells are thought to be the green power source of 21st century and may develop the hydrogen economy. However, despite of many promising breakthroughs energy production harvesting solar light does not find wide spread applications due to their low efficiency associated with unsuccessful utilization of entire solar spectrum which leads researchers to consider materials with multi energy band gap. Due to their unique property of band gap tuning (~6.2eV for AlN to ~0.65eV for InN) III-nitride nanowire structures have been extensively investigated in the past decade in pursuit of multi band gap materials. Intensive research efforts have been paid into studying GaN, InN, InGaN, AlN and their different compositions. It is clear that this material family has enormous potential in harvesting solar energy to light the new dawn of clean and sustainable energy sources. In this article, we present an overview on recent advancements in III-nitride solar energy devices. We have made a review for more than 200 articles in this regard. All the recent developments in realizing III-nitride nanostructures and novel yet recent advances in III-nitride solar devices are reviewed in and its subsequent subsections. The III-nitride nanowire photovoltaic devices are discussed in whereas deals with the current progresses in artificial photosynthesis involving III-nitride nanowires. Finally in the present challenges in realizing high efficiency III-nitride nanowire solar energy devices are summarized along with paths for future work.</P>

Extended Study of Visible-Light-Induced Photocatalytic [4 + 2] Benzannulation: Synthesis of Polycyclic (Hetero)Aromatics

Chatterjee, Tanmay,Lee, Da Seul,Cho, Eun Jin American Chemical Society 2017 Journal of organic chemistry Vol.82 No.8

<P>Herein we report an extended study of [4 + 2] benzannulation reactions of 2-(hetero)aryl-substituted,anilines with alkynes by visible light photocatalysis. The method requires the use of BuONO as a diazotizing agent and 0.3 mol % of fac-Ir(ppy)(3) as a photocatalyst at room temperature. The reaction-proceeded in a chemo-and regioselective manner with high functional group tolerance under mild conditions alloWing the preparation of a wide variety of polycyclic (hetero)arornatic compounds, including phenanthrenes, in moderate to high yields. This procedure is amenable to gram-scale synthesis of 9-phenyliphenanthrene.</P>

Synthesis of Substituted Oxazoles by Visible-Light Photocatalysis

Chatterjee, Tanmay,Cho, Ji Young,Cho, Eun Jin American Chemical Society etc. 2016 Journal of organic chemistry Vol.81 No.16

<P>A simple and practical method for the synthesis of substituted oxazoles has been developed using readily available alpha-bromoketones and benzylamines by visible-light photocatalysis at room temperature. The process, which requires 1 mol % of [Ru(bpy)(3)]Cl-2 photocatalyst with K3PO4 and CCl3Br, is effective for accessing a variety of valuable oxazole compounds. The synthetic utility of our protocol was also demonstrated by preparing a natural prochict, texaline.</P>

Halacaridae (Acari) from Thailand: One New and Two Known Species of the Genus Copidognathus Trouessart

Chatterjee, Tapas,Chang, Cheon-Young The Korean Society for Integrative Biology 2002 Korean journal of biological sciences Vol.6 No.3

Three halacarid species belonging to the genus Copidognathus are recorded from the shallow subtidal sands at Ko Taenae Islet (sand dune) off Ko Pha-Ngan Island, Thailand: Copidognathus thailandicus n. sp., C. euryalus Bartsch, 1997 and C. orarius Otto, 2001. Copidognathus thailandicus n. sp. comes close with C. cribrosoma (Police, 1909) and C. cribellus Bartsch, 1993 due to dorsal plates completely covered with rosette pores. Dissimilarities among them are discussed. Copidognathus euryalus and C. orarius are recorded hove for the first time from Thailand and away from its type locality. The present paper is also the first contribution on the taxonomy of Halacaridae (Acari) from Thailand.

Searching for boosted dark matter at ProtoDUNE

Chatterjee, Animesh,De Roeck, Albert,Kim, Doojin,Moghaddam, Zahra Gh.,Park, Jong-Chul,Shin, Seodong,Whitehead, Leigh H.,Yu, Jaehoon American Physical Society 2018 Physical Review D Vol.98 No.7

Global metabolomics approach in <i>in vitro</i> and <i>in vivo</i> models reveals hepatic glutathione depletion induced by amorphous silica nanoparticles

Chatterjee, Nivedita,Jeong, Jaeseong,Yoon, Dahye,Kim, Suhkmann,Choi, Jinhee Elsevier 2018 Chemico-biological interactions Vol.293 No.-

<P><B>Abstract</B></P> <P>The present study aimed to investigate the mechanisms involved in amorphous silica nanoparticles (aSiNPs)-mediated hepatotoxicity through the evaluation of changes in global metabolomics in <I>in vitro</I> and <I>in vivo</I> systems. <SUP>1</SUP>H NMR-based non-targeted global metabolomics and biochemical approaches were conducted in an aSiNPs-treated human hepatoma cell line (HepG2) and in ICR mice liver. The non-targeted NMR-based metabolomic analysis, followed by pathway analysis, revealed the perturbation of glutathione metabolism and the depletion of the glutathione pool after aSiNPs treatment in both <I>in vitro</I> (HepG2 cells) and <I>in vivo</I> systems. The total glutathione level, glutathione-S-transferase enzyme activity, and antioxidant gene expression strongly corroborated the metabolomic analysis results. The <I>in vitro</I> results were further supported by the <I>in vivo</I> data, specifically for metabolites profiling (Pearson Correlation coefficient is 0.462 (p = 0.026)). Furthermore, the depletion of glutathione, the formation of NADPH oxidase-mediated reactive oxygen species, and oxidative stress were evident in aSiNPs-treated HepG2 cells. Overall, the suppression of glutathione metabolism and oxidative stress are among the principal causes of aSiNPs-mediated hepatotoxicity.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Amorphous Silica nanoparticles (aSiNPs) exposure to HepG2 cells and ICR mice liver. </LI> <LI> Global metabolomics (NMR based) and biochemical assays reveal glutathione depletion. </LI> <LI> NADPH oxidase dependent ROS formation in aSiNPs exposed HepG2 cells. </LI> <LI> Alteration in antioxidative gene expression and GST enzyme activity. </LI> <LI> Conserved mechanisms of aSiNPs toxicity between <I>in vitro</I> and <I>in vivo</I> models. </LI> </UL> </P>

AN IMPROVED ADDITIVE MODEL FOR RELIABILITY ANALYSIS OF SOFTWARE WITH MODULAR STRUCTURE

Chatterjee, S.,Nigam, S.,Singh, J.B.,Upadhyaya, L.N. The Korean Society for Computational and Applied M 2012 Journal of applied mathematics & informatics Vol.30 No.3

Most of the software reliability models are based on black box approach and these models consider the entire software system as a single unit. Present day software development process has changed a lot. In present scenario these models may not give better results. To overcome this problem an improved additive model has been proposed in this paper, to estimate the reliability of software with modular structure. Also the concept of imperfect debugging has been also considered. A maximum likelihood estimation technique has been used for estimating the model parameters. Comparison has been made with an existing model. ${\chi}^2$ goodness of fit has been used for model fitting. The proposed model has been validated using real data.

A systems toxicology approach reveals the Wnt-MAPK crosstalk pathway mediated reproductive failure in <i>Caenorhabditis elegans</i> exposed to graphene oxide (GO) but not to reduced graphene oxide (rGO)

Chatterjee, Nivedita,Kim, Youngho,Yang, Jisu,Roca, Carlos P.,Joo, Sang-Woo,Choi, Jinhee Informa UK (TaylorFrancis) 2017 Nanotoxicology Vol.11 No.1

<P>The potential hazards of graphene nanomaterials were investigated by exposing the nematode Caenorhabditis elegans to graphene oxide (GO) and reduced graphene oxide (rGO). The underlying mechanisms of the nano-bio interaction were addressed with an integrated systems toxicology approach using global transcriptomics, network-based pathway analysis, and experimental validation of the in-silico-derived hypotheses. Graphene oxide was found to reduce the worms' reproductive health to a greater degree than rGO, but it did not affect survival (24h endpoint). Comparative analysis of GO vs. rGO effects found that the wingless-type MMTV integration site family (Wnt) pathway and the mitogen-activated protein kinase (MAPK) pathway were evoked in GO- but not in rGO-exposed worms. We therefore hypothesized that crosstalk between the Wnt and MAPK pathways is responsible for C. elegans' reproductive sensitivity to GO exposure. By targeting the individual components of the Wnt-MAPK crosstalk pathway (with qPCR gene expression and mutant reproduction analysis), we found a signaling cascade of MOM-2 -> MOM-5 -> MOM-4 -> LIT-1 -> POP-1 -> EGL-5. Specifically, the activation of POP-1 (the TCF protein homolog) and subsequent repression of the Wnt/beta-catenin target gene (EGL-5), analyzed with target-gene-specific RNAi in POP-1 mutant [pop-1(q645)] worms, were the central mechanisms of reduced reproductive potential in the worms exposed to GO. Our results highlight the distinct biological and molecular mechanisms of GO and rGO exposure and the role of Wnt-MAPK pathway crosstalk in regulating GO-induced reproductive failure in in vivo systems, and they will contribute to the development of efficient and innocuous graphene applications as well to improvements in mechanism-based risk assessment.</P>

AMATURE ASTRONOMY AND ASTRONOMY EDUCATION IN INDIA

CHATTERJEE, SOMENATH The Korean Astronomical Society 2015 天文學論叢 Vol.30 No.2

In India, astronomy has been studied from the beginning of civilization. The word amateur means involvement in work for pleasure rather than as a profesion. So, amateur astronomers, in many places, prefer to be called non-professional astronomers. In India, the history of amateur astronomy is quite bright. From the Puranic age astronomy was studied for peoples' daily life. In Ramayana, Mahabharata, there is a lot of evidence of astronomical knowledge. Veda is the main source for studying the history of Indian astronomy. Today astronomy education, consciousness of astronomy education, sky observation, etc. are dependent on non-professional astronomers. Vigyan Prasar, an Indian Govt. organization, is trying to popularize astronomy throughout the country.