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Chaoyuan Sun,Junqi He,Junfang Zheng,Shan Cheng,Duiping Feng 한국분자세포생물학회 2013 Molecules and cells Vol.36 No.1
The actin cytoskeleton plays an important role in cell shape determination, adhesion and cell cycle progression. Ezrin-radixin-moesin (ERM)-binding phosphoprotein 50 (EBP50), also known as Na+-H+ exchanger regulatory factor 1 (NHERF1), associates with actin cytoskeleton and is related to cell cycle progression. Its Ser279 and Ser301 residues are phosphorylated by cyclin-dependent kinase 2 (cdc2)/cyclin B during the mitosis phase. However, the biological significance of EBP50 phosphorylation mediated by cdc2/cyclin B is not clear. In the present study, MDA-MB-231 cells with low levels of endogenous EBP50 protein were stably trans-fected with constructs of EBP50 wild type (WT), phospho-deficient (serine 279 and serine 301 mutated to alanine-S279A/S301A) or phospho-mimetic (serine 279 and serine 301 mutated to aspartic acid-S279D/S301D) mutants. Subsequently, multiple phenotypes of these cells were characterized. Failure of cdc2/cyclin B-mediated EBP50 phosphorylation in cells expressing S279A/S301A (AA cells) significantly increased F-actin content, enhanced the adherence of cells to the extracellular matrix, altered cell morphology and caused defects in cytokinesis, as reflected in the formation of giant cells with heteroploid DNA and multinucleation or giant nuclei. Furthermore, knockdown of EBP50 expres-sion in AA cells rescued cell defects such as the cytokinesis failure and abnormal cell morphology. EBP50 S279A/ S301A had a weaker binding affinity with actin than EBP50 S279D/S301D, which might explain the increase of F-actin content in the AA cells. The present results suggest that cdc2/cyclin B-mediated EBP50 phos-phorylation may play a role in the regulation of various cell functions by affecting actin cytoskeleton reorgan-ization.
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Lightweight Intrusion Detection of Rootkit with VMI-Based Driver Separation Mechanism
( Chaoyuan Cui ),( Yun Wu ),( Yonggang Li ),( Bingyu Sun ) 한국인터넷정보학회 2017 KSII Transactions on Internet and Information Syst Vol.11 No.3
Intrusion detection techniques based on virtual machine introspection (VMI) provide high temper-resistance in comparison with traditional in-host anti-virus tools. However, the presence of semantic gap also leads to the performance and compatibility problems. In order to map raw bits of hardware to meaningful information of virtual machine, detailed knowledge of different guest OS is required. In this work, we present VDSM, a lightweight and general approach based on driver separation mechanism: divide semantic view reconstruction into online driver of view generation and offline driver of semantics extraction. We have developed a prototype of VDSM and used it to do intrusion detection on 13 operation systems. The evaluation results show VDSM is effective and practical with a small performance overhead.
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YiBo Xiong,DongXu Wen,ZhiZhen Zheng,ChaoYuan Sun,Jing Xie,JianJun Li 대한금속·재료학회 2023 METALS AND MATERIALS International Vol.29 No.10
The combination of wire arc additive manufacturing (WAAM) technology with traditional manufacturing process providesa promising method for fabricating the large and complex parts with the advantages of high performance, time-saving, lowcost and high material utilization. In order to acquire the optimal hybrid manufacturing process, the comparative study offlow behaviors and microstructure evolution of wrought and WAAMed ultrahigh-strength (UHS) steels is carried out underthe temperatures of 920–1160 ℃ and strain rates of 0.01–10 s−1 . The results show that the coarse prior austenite columnargrains and carbides in the initial microstructure of the WAAMed UHS steel contribute to the higher flow stress and slowerdynamic recrystallization (DRX) kinetics during hot deformation as compared to the wrought UHS steel. The hot activationenergy under the peak stress of the wrought and WAAMed UHS steels is estimated to be 332.3 kJ/mol and 374.1 kJ/mol,respectively. On the basis of the hot processing maps, the common optimal processing window for WAAMed and wroughtUHS steels is determined as the temperatures of 1060–1160 oC and strain rates of 0.08–0.66 s−1 . Under these deformationparameters, the microstructures of WAAMed and wrought UHS steels consist of fine DRXed grains, and the DRX behaviorsare both dominated by the discontinuous DRX and continuous DRX mechanisms.
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