Absence of 185delAG and 6174delT Mutations among Breast Cancer Patients of Eastern India

Chakraborty, Abhijit,Banerjee, Debolina,Basak, Jayasri,Mukhopadhyay, Ashis Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.17

Background: The incidence of breast cancer in India is on the rise and is rapidly becoming the number one cancer in females, pushing the cervical cancer to the second position. Most of the predisposition to hereditary breast and ovarian cancer has been attributed to inherited defects in two tumor suppressor genes BRCA1 and BRCA2. Alterations in these genes have been reported in different populations, some of which are population-specific mutations showing founder effects. Two specific mutations in the BRCA1 (185delAG) and BRCA2 (6174delT) genes have been reported to be of high prevalence in different populations. The aim of this study was to estimate the carrier frequency of 185delAG and 6174delT mutations in eastern Indian breast cancer patients. Materials and Methods: We selected 231 histologically confirmed breast cancer patients from our tertiary cancer care center in eastern India. Family history was obtained by interview or a self-reported questionnaire. The presence of the mutation was investigated by allele specific duplex/multiplex-PCR on genomic DNA extracted from peripheral blood. Results: A total of 231 patients (age range: 26-77 years), 130 with a family history and 101 without were screened. The two founder mutations 185delAG in BRCA1 and 6174delT in BRCA2 were not found in any of the subjects. This was confirmed by molecular analysis. Conclusions: Our findings suggest that these BRCA mutations may not have a strong recurrent effect on breast cancer among the eastern Indian population. The contribution of these founder mutations to breast cancer incidence is probably low and could be limited to specific subgroups. This may be particularly useful in establishing further pre-screening strategies.

UNIQUE RANGE SETS WITHOUT FUJIMOTO'S HYPOTHESIS

Chakraborty, Bikash Korean Mathematical Society 2022 대한수학회보 Vol.59 No.5

This paper studies the uniqueness of two non-constant meromorphic functions when they share a finite set. Moreover, we will give an existence of unique range sets for meromorphic functions that are the zero sets of some polynomials that do not necessarily satisfy the Fujimoto's hypothesis ([6]).

RICARDIAN EQUIVALENCE : FURTHER EVIDENCE

CHAKRABORTY, ATREYA,FARAH, ABDIKARIM M . 한국국제경제학회 1996 International Economic Journal Vol.10 No.3

The Silence of the Words

Chakraborty SRILEKHA 이화여자대학교 아시아여성학센터 2018 이화여자대학교 아시아여성학센터 학술대회자료집 Vol.2018 No.1

This article discusses the negligence given to the issues on gender and sexuality while talking about tribes in India and the one-dimensional approach towards understanding tribal woman. I have attempted to document this gap by using both a sociological perspective and also a perspective of literature to argue on the discourse behind gender and sexuality while speaking on tribes in India. The article debates that even when academics and literature choose to portray gender and sexuality in tribes, it is portrayed under a dictum of sanctity that reveals what needs to be silenced in the society. This article brings into focus how lived realities of the tribal women get shadowed under the quantitative percentage of mainstream articles. Further, I tried to conclude with my experiences of working with adolescent Santali girls in Jharkhand and also a need to include the narratives of everyday experiences of women and girls while documenting on tribes.

Biconnectivity, st-numbering and other applications of DFS using O(n) bits

Chakraborty, S.,Raman, V.,Satti, S.R. Academic Press 2017 Journal of Computer and System Sciences Vol.90 No.-

<P>We consider space efficient implementations of some classical applications of DFS including the problem of testing biconnectivity and 2-edge connectivity, finding cut vertices and cut edges, computing chain decomposition and st-numbering of a given undirected graph G on n vertices and m edges. Classical algorithms for them typically use DFS and some Omega(1gn) bits(1) of information at each vertex. Building on a recent O (n)-bits implementation of DFS due to Elmasry et al. (STACS 2015) we provide O (n)-bit implementations for all these applications of DFS. Our algorithms take O (m lg(c) n IgIgn) time for some small constant c (where c <= 2). Central to our implementation is a succinct representation of the DFS tree and a space efficient partitioning of the DFS tree into connected subtrees, which maybe of independent interest for designing other space efficient graph algorithms. (C) 2017 Elsevier Inc. All rights reserved.</P>

Impact of iron deficiency anemia on chronic periodontitis and superoxide dismutase activity: a cross-sectional study

Chakraborty, Souvik,Tewari, Shikha,Sharma, Rajinder Kumar,Narula, Satish Chander,Ghalaut, Pratap Singh,Ghalaut, Veena Korean Academy of Periodontology 2014 Journal of Periodontal & Implant Science Vol.44 No.2

Purpose: Both chronic periodontitis (CP) and iron deficiency anemia (IDA) induce oxidative stress in the body and cause an imbalance between reactive oxygen species and antioxidants, such as superoxide dismutase (SOD). This study explored the SOD enzyme activity of saliva and serum in CP patients with and without IDA and analyzed the impact of IDA on CP. Methods: A total of 82 patients were divided into four groups: control group (CG, 22), periodontally healthy IDA patients (IDA-PH, 20), CP patients (CP, 20), and IDA patients with CP (IDA-CP, 20). After clinical measurements and samplings, serum and salivary SOD levels were determined using an SOD assay kit. Results: IDA-CP patients exhibited a higher gingival index, bleeding on probing, probing pocket depth, and percentage (%) of sites with a clinical attachment loss (CAL) of ${\geq}6mm$ (P<0.008) than CP patients. The mean salivary and serum SOD levels were significantly lower in the IDA-PH, CP, and IDA-CP patients than in the CG group (P<0.008). A significant positive correlation between salivary and serum SOD activity was observed in IDA (P<0.05). Furthermore, serum and salivary SOD levels were significantly and negatively correlated with all periodontal parameters including the percentage of sites with CAL of 4-5 and ${\geq}6mm$ (P<0.05) except the significant correlation between salivary SOD activity and mean CAL and the percentage of sites with CAL of 4-5 mm (P>0.05) in these patients. Conclusions: Within the limits of this study, it may be suggested that IDA patients with chronic periodontitis have more periodontal breakdowns than patients with chronic periodontitis. Serum and salivary SOD activity levels were lower in the IDA-PH, CP and IDA-CP groups than in the CG. Iron deficiency anemia influenced the serum SOD activity but did not seem to affect the salivary SOD activity in these patients.

SOME RESULTS ON THE UNIQUE RANGE SETS

Chakraborty, Bikash,Kamila, Jayanta,Pal, Amit Kumar,Saha, Sudip Korean Mathematical Society 2021 대한수학회지 Vol.58 No.3

In this paper, we exhibit the equivalence between different notions of unique range sets, namely, unique range sets, weighted unique range sets and weak-weighted unique range sets under certain conditions. Also, we present some uniqueness theorems which show how two meromorphic functions are uniquely determined by their two finite shared sets. Moreover, in the last section, we make some observations that help us to construct other new classes of unique range sets.

Spirituality bestowing self-transcendence amid COVID-19 through slow fashion

Chakraborty Swagata,Sadachar Amrut 한국마케팅과학회 2023 Journal of Global Fashion Marketing Vol.14 No.3

We proposed and tested a conceptual model exploring how (i) COVID-stress evokes spirituality; (ii) COVID-stress and spirituality engender positive attitude toward the different dimensions of slow fashion (i.e. equity, authenticity, functionality, localism, and exclusivity) as a symbol of self-transcendence and (iii) spirituality mediates the relationships between COVID-stress and the different dimensions of slow fashion. We conducted an online survey in Amazon Mechanical Turk (n = 317) and analyzed the data through structural equation modeling. (i) COVID-stress positively influences spirituality; (ii) both COVID-stress and spirituality positively influ- ence attitude toward slow fashion in terms of equity, authenticity, localism, and exclusivity; (iii) spirituality mediates the relationships between COVID-stress and all the dimensions of slow fashion except for functionality. Due to the fast-changing situations amid the pandemic and the uneven severity of the pandemic globally, a cross-sectional study may have limited the scope for capturing nuances of retail consumer behavior. In summary, we suggest that the consumption of slow fashion apparel as a symbol of self- transcendence may help consumers cope with COVID-stress in the hope of building spiritual ties with a higher power through the process of ethical consumption amid the pandemic.

Electromagnetic Interference Reflectivity of Nanostructured Manganese Ferrite Reinforced Polypyrrole Composites

Chakraborty, Himel,Chabri, Sumit,Bhowmik, Nandagopal The Korean Institute of Electrical and Electronic 2013 Transactions on Electrical and Electronic Material Vol.14 No.6

Nano-size manganese ferrite reinforced conductive polypyrrole composites reveal a core-shell structure by in situ polymerization, in the presence of dodecyl benzene sulfonic acid as the surfactant and dopant, and iron chloride as the oxidant. The structure and magnetic properties of manganese ferrite nano-fillers were measured, by using X-ray diffraction and vibrating sample magnetometer. The morphology, microstructure, and conductivity of the composite were characterized by transmission electron microscopy, Fourier transform infrared spectroscopy, and four-wire technique. The microwave-absorbing properties of composites reinforcement dispersed in resin coating with the coating thickness of 1.2 nm were investigated, by using vector network analyzers, in the frequency range of 8~12 GHz. A reflection loss of -8 dB was observed at 10.5 GHz.

Micro-Environmental Signature of The Interactions between Druggable Target Protein, Dipeptidyl Peptidase-IV, and Anti-Diabetic Drugs

Chakraborty, Chiranjib,Mallick, Bidyut,Sharma, Ashish Ranjan,Sharma, Garima,Jagga, Supriya,Doss, C George Priya,Nam, Ju-Suk,Lee, Sang-Soo Royan Institute 2017 Cell journal (Yakhteh) Vol.19 No.1

<P><B>Objective</B></P><P> Druggability of a target protein depends on the interacting micro-environment between the target protein and drugs. Therefore, a precise knowledge of the interacting micro-environment between the target protein and drugs is requisite for drug discovery process. To understand such micro-environment, we performed in silico interaction analysis between a human target protein, Dipeptidyl Peptidase-IV (DPP-4), and three anti-diabetic drugs (saxagliptin, linagliptin and vildagliptin). </P><P><B>Materials and Methods</B></P><P> During the theoretical and bioinformatics analysis of micro-environmental properties, we performed drug-likeness study, protein active site predictions, docking analysis and residual interactions with the protein-drug interface. Micro-environmental landscape properties were evaluated through various parameters such as binding energy, intermolecular energy, electrostatic energy, van der Waals’+H-bond+desolvo energy (E<SUB>VHD</SUB>) and ligand efficiency (LE) using different in silico methods. For this study, we have used several servers and software, such as Molsoft prediction server, CASTp server, AutoDock software and LIGPLOT server. </P><P><B>Results</B></P><P> Through micro-environmental study, highest log P value was observed for linagliptin (1.07). Lowest binding energy was also observed for linagliptin with DPP-4 in the binding plot. We also identified the number of H-bonds and residues involved in the hydrophobic interactions between the DPP-4 and the anti-diabetic drugs. During interaction, two H-bonds and nine residues, two H-bonds and eleven residues as well as four H-bonds and nine residues were found between the saxagliptin, linagliptin as well as vildagliptin cases and DPP-4, respectively. </P><P><B>Conclusion</B></P><P>Our in silico data obtained for drug-target interactions and micro-environmental signature demonstrates linagliptin as the most stable interacting drug among the tested anti-diabetic medicines.</P>