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- 저자 : Cha-Chun Chen (검색결과 2 건)
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Application of Auriculotherapy for Post-Burn Scar Syndrome in Young Adults with Major Burns
Cha-Chun Chen,San-Pei Chen,Shu-Yu Lyu,Chung-Hua Hsu 사단법인약침학회 2021 Journal of Acupuncture & Meridian Studies Vol.14 No.4
Background: A burn scar is a type of hypertrophic scar that can cause significant clinical symptoms, discomfort, and post-burn scar (PBS) syndrome in up to 77% of patients with burn injuries. Medication and rehabilitation are rarely effective at managing patient discomfort, and both laser and surgical interventions are postponed until the scar stabilizes and discomfort is tolerable. Objectives: The present study was conducted to investigate the effectiveness of auricular acupuncture among burn victims from the Formosa Color Dust Explosion in Taiwan. Methods: We enrolled 31 victims of the 2016 Formosa Color Dust Explosion who met the study inclusion criteria. The intervention involved placement of magnetic beads over the auricular Shenmen and Subcortex acupoints on one ear. Patients performed selfmassage five times per day, and both magnet beads were removed between the fifth and seventh days during the sessions. Several evaluation tools were used to assess clinical symptoms: the visual analogue scale for pain assessment, Burn Man Itch Scale for perceived patient itchiness, 5-D Pruritus Scale for sleep quality, and heart rate variability (HRV) for effects on the autonomic nervous system. Results: The clinical symptoms were significantly decreased following the intervention, but the effect did not endure. The normal-to-normal heart rate interval, heart rate analysis abnormalities, and very low frequency heart rate were significantly decreased among patients with abnormal HRV (SD < 40) following treatment. Conclusion: Stimulation of the auricular Shenmen and Subcortex acupoints may effectively reduce pain, itchiness, and sleep disturbances among patients with PBS syndrome.
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Shin, Eun-Joo,Nah, Seung-Yeol,Kim, Won-Ki,Ko, Kwang Ho,Jhoo, Wang-Kee,Lim, Yong-Kwang,Cha, Joo Young,Chen, Chieh-Fu,Kim, Hyoung-Chun Nature Publishing Group 2005 British journal of pharmacology Vol.144 No.7
In a previous study, we demonstrated that a dextromethorphan analog, dimemorfan, has neuroprotective effects.Dextromethorphan and dimemorfan are high-affinity ligands at σ<SUB>1</SUB> receptors. Dextromethorphan has moderate affinities for phencyclidine sites, while dimemorfan has very low affinities for such sites, suggesting that these sites are not essential for the anticonvulsant actions of dimemorfan.Kainate (KA) administration (10 mg kg<SUP>−1</SUP>, i.p.) produced robust convulsions lasting 4–6 h in rats. Pre-treatment with dimemorfan (12 or 24 mg kg<SUP>−1</SUP>) reduced seizures in a dose-dependent manner. Dimemorfan pre-treatment also attenuated the KA-induced increases in c-fos/c-jun expression, activator protein (AP)-1 DNA-binding activity, and loss of cells in the CA1 and CA3 fields of the hippocampus. These effects of dimemorfan were comparable to those of dextromethorphan.The anticonvulsant action of dextromethorphan or dimemorfan was significantly counteracted by a selective σ<SUB>1</SUB> receptor antagonist BD 1047, suggesting that the anticonvulsant action of dextromethorphan or dimemorfan is, at least in part, related to σ<SUB>1</SUB> receptor-activated modulation of AP-1 transcription factors.We asked whether dimemorfan produces the behavioral side effects seen with dextromethorphan or dextrorphan (a phencyclidine-like metabolite of dextromethorphan). Conditioned place preference and circling behaviors were significantly increased in mice treated with phencyclidine, dextrorphan or dextromethorphan, while mice treated with dimemorfan showed no behavioral side effects.Our results suggest that dimemorfan is equipotent to dextromethorphan in preventing KA-induced seizures, while it may lack behavioral effects, such as psychotomimetic reactions.British Journal of Pharmacology (2005) 144, 908–918. doi:10.1038/sj.bjp.0705998
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