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- 저자 : Castilla, Ana M. (검색결과 3 건)
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Chronic Management of Hypertension after Stroke: The Role of Ambulatory Blood Pressure Monitoring
Luis Castilla-Guerra,Maria del Carmen Fernandez-Moreno 대한뇌졸중학회 2016 Journal of stroke Vol.18 No.1
Hypertension is the most important potentially reversible risk factor for stroke in all age groups; high blood pressure (BP) is also associated with increased risk of recurrent stroke in patients who have already had an ischemic or hemorrhagic event. Twenty-four hour ambulatory BP monitoring (ABPM) has become an important tool for improving the diagnosis and management of hypertension, and is increasingly used to assess patients with hypertension. Nevertheless, although ABPM devices are increasingly used for assessment of hypertension, their value in the chronic management of hypertension in patients with stroke has not been systematically studied. In fact, among large-scale randomized trials for secondary stroke prevention, only the Morbidity and Mortality After Stroke, Eprosartan Compared With Nitrendipine for Secondary Prevention trial included 24-hour ABPM. ABPM has demonstrated chronic disruption of the circadian rhythm of BP after acute phase of stroke and has shown higher sensitivity compared to office BP in evaluating the effectiveness of antihypertensive treatment among stroke survivors. High 24-hour BP is an independent predictor for cerebrovascular events, brain microbleeds, and subsequent development of dementia. Nevertheless, although stroke care guidelines endorse the importance of hypertension management, the specific role of ABPM among stroke survivors after the acute phase of disease has not been established. Further studies are needed to clarify whether routine application of ABPM among these patients should be recommended.
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Ousaka, Naoki,Grunder, Sergio,Castilla, Ana M.,Whalley, Adam C.,Stoddart, J. Fraser,Nitschke, Jonathan R. American Chemical Society 2012 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.134 No.37
<P>A series of large, optically active Fe<SUB>4</SUB>L<SUB>6</SUB> cages was prepared from linear 5,5′-bis(2-formylpyridines) incorporating varying numbers (<I>n</I> = 0–3) of oligo-<I>p</I>-xylene spacers, chiral amines, and Fe<SUP>II</SUP>. When a cage was constructed from the ligand bridged by one <I>p</I>-xylene spacer (<I>n</I> = 1) and a bulky chiral amine, both a homochiral Fe<SUB>2</SUB>L<SUB>3</SUB> helicate and Fe<SUB>4</SUB>L<SUB>6</SUB> cage were observed to coexist in solution due to a delicate balance between steric factors. In contrast, when a less bulky chiral amine was used, only the Fe<SUB>4</SUB>L<SUB>6</SUB> cage was observed. In the case of larger cages (<I>n</I> = 2, 3), long-range (>2 nm) stereochemical coupling between metal centers was observed, which was minimally diminished as the ligands were lengthened. This communication was mediated by the ligands’ geometries and rigidity, as opposed to gearing effects between xylene methyl groups: the metal-centered stereochemistry was not observed to affect the axial stereochemistry of the ligands.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/2012/jacsat.2012.134.issue-37/ja306615d/production/images/medium/ja-2012-06615d_0014.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ja306615d'>ACS Electronic Supporting Info</A></P>
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