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      • KCI등재

        A Randomized, Double-Blind, Placebo-Controlled, Multi-Centered Clinical Study to Evaluate the Efficacy and Safety of Artemisia annua L. Extract for Improvement of Liver Function

        ( Byoungduck Han ),( Seon-mee Kim ),( Ga Eun Nam ),( Seon-hee Kim ),( Su-jin Park ),( Young-kyu Park ),( Hyun Wook Baik ) 한국임상영양학회 2020 Clinical Nutrition Research Vol.9 No.4

        Non-alcoholic fatty liver disease (NAFLD) has the potential to develop into hepatic steatosis and progress to terminal liver diseases such as cirrhosis and hepatocellular carcinoma. This human clinical study was aimed to demonstrate that SPB-201 (powdered-water extract of Artemisia annua) can improve liver function in subjects with non-alcoholic liver dysfunction at mild to moderate levels. A decrease of 271% in aspartate aminotransferase (AST) level and a significant decrease of 334% in alanine aminotransferase (ALT) level was observed in the test group as compared to the control group at the 4 weeks follow-up. In addition, after 8 weeks, decreases of 199% in AST level and 216% in ALT level were reported in the test group as compared to the control group. These results confirmed that SPB-201 intake significantly enhanced liver function and health. Moreover, the Multidimensional Fatigue Scale score of the test group decreased but that of the control group increased, implicating that SPB-201 also eliminated overall fatigue. No significant adverse events were observed among all subjects during the study. Taken together, our clinical study confirmed the excellent efficacy and safety of SPB-201 in liver function improvement, showing the possibility of SPB-201 as a functional food to restore liver dysfunction and treat liver diseases.

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        Associations between Living Alone and Smoking and Alcohol Consumption in Korean Adults

        Sang-Woo Lee,Byoungduck Han,Sung Jung Cho,Seung Jin Jung,허연,Junghun Kim,Do Hyun Eum,Taeryoon Kim,Soon-Hong Min,Woohyun Lee,Jinhee Cho,Min Hee Kwon,Ga Eun Nam 대한가정의학회 2020 Korean Journal of Family Medicine Vol.41 No.5

        Background: Recently, single-person households have increased in Korea and this trend may have potential public health implications and affect various health behaviors. This study investigated the associations between living alone and health behaviors such as smoking and alcohol consumption among Korean adults. Methods: We used data from the 6th Korea National Health and Nutrition Examination Survey between 2013 and 2015 and a total of 17,088 adults were included. We performed a multivariable logistic regression analysis and calculated odds ratios (ORs) with 95% confidence intervals (CIs). Results: Single-person households accounted for about 10% of the total participants. The proportions of currently smoking and heavy alcohol consumption were higher among individuals living alone than those living together among younger women and middle-aged and elderly men and women. In the multivariable logistic regression analysis, living alone was associated with increased odds of currently smoking compared to living together among middle-aged men and women (OR, 7.37; 95% CI, 2.33–23.32 in men and OR, 2.36; 95% CI, 1.04–5.36 in women) after adjusting for confounding variables. Conclusion: From this nationwide, population-based study, we found that living alone is associated with increased odds of currently smoking, especially in middle-aged people. Public health concerns may be warranted for middleaged single-person households to reduce health risks related to smoking.

      • KCI등재

        한국 노인에서 맥압과 관상동맥질환의 연관성 : 제 7기 한국 국민건강영양조사(2016-2018)

        Yoojeong Lee,Geeyon Seo,Jiae Heo,Junggoo Kim,Hyojin Park,Jean Shin,Byoungduck Han,Joung Sik Son,Seon Mee Kim 대한임상노인의학회 2021 대한임상노인의학회지 Vol.22 No.2

        Background: Although the pulse pressure (PP) is an independent predictor of coronary heart disease (CHD), many physicians disregard its importance and there have been no recent studies on Korean elderly. We investigated the association between PP and CHD in Korean elderly through the nationwide, observational study. Methods: This study included 4100 subjects aged ≥65 years from the 7th Korean National Health and Nutrition Examination Survey (2016-2018). Pulse pressure was calculated as the difference between the systolic blood pressure (SBP) and the diastolic blood pressure (DBP), and high PP was defined as ≥60 mmHg. Subjects diagnosed with angina pectoris or myocardial infarction were classified into the CHD group. Multivariate logistic regression analysis was performed to evaluate the association between PP and CHD. Results: Among the subjects, the incidence of high PP was higher in women, while CHD was higher in men. Subjects with high PP were older, had higher SBP, lower DBP and higher FBG compared to subjects with normal PP. After adjustment for multiple covariates, participants with high PP had a higher risk for incidence of CHD with an OR of 1.361 (95% of CI: 1.077-1.719). Conclusions: In this study, we found the significant association between PP and CHD in Korean elderly.

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