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LB30057 Inhibits Platelet Aggregation and Vascular Relaxation Induced by Thrombin
Byoung-InJung,Kyu-TaeKang,배옥남,Moo-YeolLee,Seung-MinChung,Sang-KooLee,In-ChulKim,Jin-HoChung 대한약학회 2002 Archives of Pharmacal Research Vol.25 No.6
Previous study showed that an amidrazonophenylalanine derivative, LB30057, which has high water solubility, inhibited the catalytic activity of thrombin potently by interaction with the active site of thrombin. In the current investigation, we examined whether LB30057 inhibited platelet aggregation and vascular relaxation induced by thrombin. Treatment with LB30057 to plateletrich plasma (PRP) isolated from human blood resulted in a concentration-dependent inhibition of thrombin-induced aggregation. Values for IC50 and IC100 were 54 ± 4 nM and 96 ± 3 nM, respectively. This inhibition was agonist (thrombin) specific, since IC50 values for collagen and ADP were much greater than those for thrombin. In addition, concentration-dependent inhibitory effects were observed on the serotonin secretion induced by thrombin in PRP. Consistent with these findings, thrombin-induced increase in cytosolic calcium levels was inhibited in a concentration-dependent manner. When LB30057 was treated with aortic rings isolated from rats, LB30057 resulted in a concentration-dependent inhibition of thrombin-induced vascular relaxation. All these results suggest that LB30057 is a potent inhibitor of platelet aggregation and blood vessel relaxation induced by thrombin.
양단고정(兩端固定) 변단면(變斷面) 원호(圓弧)아-치의 수치해석(數値解析)에 관(關)한 연구(硏究)
박문호 ( Moon Ho Park ),이병구 ( Byoung Koolee ) 한국농공학회 1977 韓國農工學會誌 : 전원과 자원 Vol.19 No.3
The governing differential equations for the tapered circular arch with fixed ends have been derived, and a numerical procedure for the solution of these equations have been developed. The governing differential equations were solved numerically by an initial value integration procedure and Shooting Methods for boundary value problems. The Rungekutta fourth order integration technique was used. The methods was programmed for a Cyber 73-18 computer System, and all esults were obtained on this computer. A detailed study has been made for a fixed arch with an angle of opening equal to 0.7 radian, and the results are presented in detail in tables and curves. It is hoped that the results presented herein is applied to the deformations of gives point from the tri-axial direction of tapered circular arch with fixed ends, bending moment, and torsional moment, and that at the same time results to be used for archwise structures in steel structure.