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( Byeonghyeon Kim ),( Hye Ran Kim ),( Ki Hyun Kim ),( Sang Yun Ji ),( Minji Kim ),( Yookyung Lee ),( Sung Dae Lee ),( Jin Young Jeong ) 한국축산학회(구 한국동물자원과학회) 2021 한국축산학회지 Vol.63 No.2
Heat stress (HS) causes adverse impacts on pig production and health. A potential biomarker of HS is required to predict its occurrence and thereby better manage pigs under HS. Information about the saliva metabolome in heat-stressed pigs is limited. Therefore, this study was aimed to investigate the effects of acute HS on the saliva metabolome and identify metabolites that could be used as potential biomarkers. Growing pigs (n = 6, 3 boars, and 3 gilts) were raised in a thermal neutral (TN; 25℃) environment for a 5-d adaptation period (CON). After adaptation, the pigs were first exposed to HS (30℃; HS30) and then exposed to higher HS (33℃; HS33) for 24 h. Saliva was collected after adaptation, first HS, and second HS, respectively, for metabolomic analysis using 1H-nuclear magnetic resonance spectroscopy. Four metabolites had significantly variable importance in the projection (VIP > 1; p < 0.05) different levels in TN compared to HS groups from all genders (boars and gilts). However, sex-specific characteristics affected metabolites (glutamate and leucine) by showing the opposite results, indicating that HS was less severe in females than in males. A decrease in creatine levels in males and an increase in creatine phosphate levels in females would have contributed to a protective effect from protein degradation by muscle damage. The results showed that HS led to an alteration in metabolites related to energy and protein. Protection from muscle damage may be attributed to the alteration in protein-related metabolites. However, energy-related metabolites showed opposing results according to sex-specific characteristics, such as sex hormone levels and subcutaneous fat layer. This study had shown that saliva samples could be used as a noninvasive method to evaluate heat-stressed pigs. And the results in this study could be contributed to the development of a diagnostic tool as a noninvasive biomarker for managing heat-stressed pigs.
( Byeonghyeon Kim ),( Kondreddy Eswar Reddy ),( Hye Ran Kim ),( Ki Hyun Kim ),( Yookyung Lee ),( Minji Kim ),( Sang Yun Ji ),( Sung Dae Lee ),( Jin Young Jeong ) 한국축산학회(구 한국동물자원과학회) 2021 한국축산학회지 Vol.63 No.3
Heat stress (HS) damages health and decreases performance variables in pigs, and if severe enough, causes mortality. However, metabolic changes under HS and recovery following HS are poorly understood. Therefore, this study was aimed to expose the essential mechanisms by which growing pigs respond to HS and the temporal pattern of plasma concentrations (PC) of amino acids (AAs) and metabolites. Crossbred male growing pigs were penned separately and allowed to adapt to thermal-neutral (TN) conditions (20℃ and 80% relative humidity; TN[- 1D]). On the first day, all pigs were exposed to HS for 24 h (36℃ and 60% relative humidity), then to TN conditions for 5 days (TN[2D] to TN[5D]). All pigs had ad libitum access to water and 3 kg feed twice daily. Rectal temperature (RT) and feed intake (FI) were determined daily. HS pigs had higher RT (40.72℃) and lower (50%) FI than TN(-1D) pigs (p < 0.01). The PC of indispensable (threonine, valine, and methionine) and dispensable (cysteine and tyrosine) AAs were higher (p < 0.05) in HS than TN(-1D) pigs and remained increased during recovery time. Nonprotein α-aminobutyric acid and β-alanine concentrations were higher (p < 0.05) in HS than TN(-1D) pigs. The metabolite concentration of creatinine was higher (p < 0.01) under HS treatment than other treatments, but that of alanine and leucine remained increased (p < 0.05) through 5 d of recovery. In summary, some major differences were found in plasma AA profiles and metabolites between HS- and TN-condition pigs. This indicates that the HS pigs were forced to alter their metabolism, and these results provide information about mechanisms of acute HS responses relative to the recovery time.
가상현실 기술을 활용한 사격훈련용 모바일 애플리케이션 개발
이병현 ( Lee Byeonghyeon ),김재철 ( Kim Jaecheol ) 공군사관학교 2018 空士論文集 Vol.69 No.2
본 연구는 안드로이드 운영체제를 탑재한 스마트폰을 위한 가상현실 기반의 사격연습용 앱을 개발하고 구현한 논문으로서 특별히 K-2 소총과 K-5 권총을 활용한 사격훈련을 모의할 수 있도록 개발하였다. 기존의 사격훈련용 소프트웨어는 고가의 격발장치, 스크린장치, 데이터처리장치 등을 필요로 하였으나, 본 연구는 스마트폰 외의 다른 일체의 부가 장비 없이 사격훈련의 전체 과정을 실제 사격과정과 동일하게 모사하였다는 점이 특징이다. 스마트폰이 탑재하고 있는 터치 센서와 자이 로스코프 센서를 활용하여, 조준선 및 표적 정렬과정을 구현하였고, 격발은 스마트폰의 물리버튼을 누름으로써 구현되게 하였다. 대부분의 생도 및 간부가 소지하고 있는 스마트폰을 활용하여 언제 어디서나 개인화기인 권총 및 소총 사격훈련에 활용할 수 있다는 점에서 효용성과 차별성이 있는 연구이다. This study develops and implements a virtual reality based mobile application for shooting training which runs on a smartphone with the Android operating system. The application simulates the shooting of K-2 rifle and K-5 pistol under the fully virtual reality environment. There are many kinds of software systems for shooting training, but they require costly additional devices which include shooting guns, screens, data processing systems, and etc. On the other side, this study is exceptional in the aspect that it simulates the full process of shooting training without any additional hardware nor software devices but a smartphone. The built in touch sensor and gyroscope sensor are key tools for sightseeing line sorting and target alignment. Triggering is simulated by pressing the physical volume down button. Through the application of this study, personal smartphones of cadets and officers can be utilized for shooting training anywhere, anytime, where this study stands out quite noticeably.
Ryu, Nari,Lee, Seokwon,Park, Hong-Joon,Lee, Byeonghyeon,Kwon, Tae-Jun,Bok, Jinwoong,Park, Chan Ik,Lee, Kyu-Yup,Baek, Jeong-In,Kim, Un-Kyung Elsevier BV 2017 Gene Vol.627 No.-
<P><B>Abstract</B></P> <P>Hereditary hearing loss (HHL) is a common genetically heterogeneous disorder, which follows Mendelian inheritance in humans. Because of this heterogeneity, the identification of the causative gene of HHL by linkage analysis or Sanger sequencing have shown economic and temporal limitations. With recent advances in next-generation sequencing (NGS) techniques, rapid identification of a causative gene <I>via</I> massively parallel sequencing is now possible. We recruited a Korean family with three generations exhibiting autosomal dominant inheritance of hearing loss (HL), and the clinical information about this family revealed that there are no other symptoms accompanied with HL. To identify a causative mutation of HL in this family, we performed whole-exome sequencing of 4 family members, 3 affected and an unaffected. As the result, A novel splicing mutation, c.763+1G>T, in the solute carrier family 17, member 8 (<I>SLC17A8</I>) gene was identified in the patients, and the genotypes of the mutation were co-segregated with the phenotype of HL. Additionally, this mutation was not detected in 100 Koreans with normal hearing. <I>Via</I> NGS, we detected a novel splicing mutation that might influence the hearing ability within the patients with autosomal dominant non-syndromic HL. Our data suggests that this technique is a powerful tool to discover causative genetic factors of HL and facilitate diagnoses of the primary cause of HHL.</P> <P><B>Highlights</B></P> <P> <UL> <LI> NGS is a powerful method to facilitate discovery and diagnosis of causative factors in genetic hearing loss. </LI> <LI> We performed whole exome sequencing to screen the genetic cause of autosomal dominant non-syndromic hearing loss. </LI> <LI> A probably pathogenic, novel splicing mutation was found in the <I>SLC17A8</I> gene. </LI> <LI> Our results provide essential information to understand hearing loss caused by a splicing mutation in the <I>SLC17A8</I> gene. </LI> </UL> </P>
류마티스 관절염 환자의 통증 감소를 위한 프로그램의 효과: 체계적 문헌고찰
전병현(Jeon, Byeonghyeon),이창훈(Lee, Chang Hoon),정종혁(Chung, Chong Hyuk),이명수(Lee, Myeung Su) 대한근관절건강학회 2021 근관절건강학회지 Vol.28 No.2
Purpose: The purpose of this study was to establish the foundations for the application of appropriate programs for pain reduction in patients with rheumatoid arthritis. Methods: The literature on patients with rheumatoid arthritis were found on an electronic search site for South Korean academic papers. The search terms “rheumatism” and “rheumatoid arthritis” were used independently. The combined terms “rheumatism and pain and “rheumatoid arthritis and pain were also used. For the meta-analysis, the R version 3.5.1 program was utilized. Results: The meta-analysis of eight papers showed a large effect size of -4.11. The programs were most effective in the order of aquatic exercise, aromatherapy, self-help education, muscle strength exercises, and tai chi. Conclusion: This study could provide the basis for presenting appropriate programs for pain management in patients with rheumatoid arthritis.
A case of CHARGE syndrome featuring immunodeficiency and hypocalcemia
Yu Yun Son,Byeonghyeon Lee,Chae-Ri Suh,Hyo-Kyoung Nam,Jung Hwa Lee,Young Sook Hong,Joo Won Lee 대한의학유전학회 2015 대한의학유전학회지 Vol.12 No.1
CHARGE syndrome (coloboma, heart defects, atresia choanae, retarded growth and development, genital hypoplasia, and ear abnormalities) is characterized by multiple malformations and is diagnosed using distinct consensus criteria. Mutations in the gene encoding chromodomain helicase DNA-binding protein 7 (CHD7) are the major cause of CHARGE syndrome. Clinical features of CHARGE syndrome considerably overlap those of 22q11.2 deletion syndrome. Of these features, immunodeficiency and hypocalcemia are frequently reported in patients with 22q11.2 deletion syndrome but are rarely reported in patients with CHARGE syndrome. In this report, we have described the case of a patient with typical phenotypes of 22q11.2 deletion syndrome but without the proven chromosome microdeletion. Mutation analysis of CHD7 identified a pathogenic mutation (c.2238+1G>A) in this patient. To our knowledge, this is the first case of CHARGE syndrome with immunodeficiency and hypocalcemia in Korea. Our observations suggest that mutation analysis of CHD7 should be performed for patients showing the typical phenotypes of 22q11.2 deletion syndrome but lacking the proven chromosome microdeletion
A case of CHARGE syndrome featuring immunodeἀciency and hypocalcemia
Yu Yun Son,Byeonghyeon Lee,Chae-Ri Suh,Hyo-Kyoung Nam,Jung Hwa Lee,Young Sook Hong,Joo Won Lee 대한의학유전학회 2015 대한의학유전학회지 Vol.12 No.1
CHARGE syndrome (coloboma, heart defects, atresia choanae, retarded growth and development, genital hypoplasia, and ear abnormalities) is characterized by multiple malformations and is diagnosed using distinct consensus criteria. Mutations in the gene encoding chromodomain helicase DNA-binding protein 7 (CHD7) are the major cause of CHARGE syndrome. Clinical features of CHARGE syndrome considerably overlap those of 22q11.2 deletion syndrome. Of these features, immunodeficiency and hypocalcemia are frequently reported in patients with 22q11.2 deletion syndrome but are rarely reported in patients with CHARGE syndrome. In this report, we have described the case of a patient with typical phenotypes of 22q11.2 deletion syndrome but without the proven chromosome microdeletion. Mutation analysis of CHD7 identified a pathogenic mutation (c.2238+1G>A) in this patient. To our knowledge, this is the first case of CHARGE syndrome with immunodeficiency and hypocalcemia in Korea. Our observations suggest that mutation analysis of CHD7 should be performed for patients showing the typical phenotypes of 22q11.2 deletion syndrome but lacking the proven chromosome microdeletion.