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Effects of Dietary Flaxseed Lignan Extract on Symptoms of Benign Prostatic Hyperplasia
Wei Zhang,Xiaobing Wang,Yi Liu,Haimei Tian,Brent Flickinger,Mark W. Empie,Sam Z. Sun 한국식품영양과학회 2008 Journal of medicinal food Vol.11 No.2
A flaxseed lignan extract containing 33% secoisolariciresinol diglucoside (SDG) was evaluated for its abilityto alleviate lower urinary tract symptoms (LUTS) in 87 subjects with benign prostatic hyperplasia (BPH). A randomized, dou-ble-blind, placebo-controlled clinical trial with repeated measurements was conducted over a 4-month period using treatmentdosages of 0 (placebo), 300, or 600 mg/day SDG. After 4 months of treatment, 78 of the 87 subjects completed the study.For the 0, 300, and 600 mg/day SDG groups, respectively, the International Prostate Symptom Score (IPSS) decreased . 3.67.1.56, . 7.33. 1.18, and . 6.88. 1.43 (mean. SE, P. .100,. .001, and. .001 compared to baseline), the Quality of Lifescore (QOL score) improved by . 0.71. 0.23, . 1.48. 0.24, and . 1.75. 0.25 (mean. SE, P. .163 and .012 comparedto placebo and P. .103,. .001, and. .001 compared to baseline), and the number of subjects whose LUTS grade changedfrom “moderate/severe” to “mild” increased by three, six, and 10 (P. .188, .032, and .012 compared to baseline). Maximumurinary flows insignificantly increased 0.43. 1.57, 1.86. 1.08, and 2.7. 1.93 mL/second (mean. SE, no statistical sig-nificance reached), and postvoiding urine volume decreased insignificantly by . 29.4. 20.46, . 19.2. 16.91, and . 55.62.36.45 mL (mean. SE, no statistical significance reached). Plasma concentrations of secoisolariciresinol (SECO), enterodiol(ED), and enterolactone (EL) were significantly raised after the supplementation. The observed decreases in IPSS and QOLscore were correlated with the concentrations of plasma total lignans, SECO, ED, and EL. In conclusion, dietary flaxseed lig-nan extract appreciably improves LUTS in BPH subjects, and the therapeutic efficacy appeared comparable to that of com-monly used intervention agents of .1A-adrenoceptor blockers and 5.-reductase inhibitors.
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