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- 저자 : Boram Ku (검색결과 3 건)
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Kim, Boram,Jung, In Hwan,Kang, Mijeong,Shim, Hong-Ku,Woo, Han Young American Chemical Society 2012 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.134 No.6
<P>We demonstrate highly sensitive and selective potassiumion detectionagainst excess sodium ions in water, by modulating the interactionbetween the G-quadruplex-forming molecular beacon aptamer (MBA) andcationic conjugated polyelectrolyte (CPE). The K<SUP>+</SUP>-specificaptamer sequence in MBA is used as the molecular recognition element,and the high binding specificity of MBA for potassium ions offersselectivity against a range of metal ions. The hairpin-type MBA labeledwith a fluorophore and quencher at both termini undergoes a conformationalchange (by complexation with CPEs) to either an open-chain form ora G-quadruplex in the absence or presence of K<SUP>+</SUP> ions. Conformationalchanges of MBA as well as fluorescence (of the fluorophore in MBA)quenching or amplification via fluorescence resonance energy transferfrom CPEs provide clear signal turn-off and -on in the presence orabsence of K<SUP>+</SUP>. The detection limit of the K<SUP>+</SUP> assays is determined to be ∼1.5 nM in the presence of 100mM Na<SUP>+</SUP> ions, which is ∼3 orders of magnitude lowerthan those reported previously. The successful detection of 5′-adenosinetriphosphate (ATP) with the MBA containing an ATP-specific aptamersequence is also demonstrated using the same sensor scheme. The schemereported herein is applicable to the detection of other kinds of G-richaptamer-binding chemicals and biomolecules.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/2012/jacsat.2012.134.issue-6/ja210360v/production/images/medium/ja-2011-10360v_0010.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ja210360v'>ACS Electronic Supporting Info</A></P>
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유미,양미란,Boram Ku,Jon S. Mann 한국간호과학회 2021 Asian Nursing Research Vol.15 No.3
Purpose: Virtual reality simulation can give nursing students a safe clinical experience involving highrisk infants where access to neonatal intensive care units is limited. This study aimed to examine the effects of a virtual reality simulation program on Korean nursing students’ knowledge, performance selfefficacy and learner satisfaction. Methods: A nonequivalent control group design was applied. Senior nursing students were divided into an experimental group (n = 25) experiencing virtual reality simulation and routine neonatal intensive care unit practice and a control group (n = 25) having routine neonatal intensive care unit practice. The program consisted of three scenarios: basic care, feeding management and skin care and environmental management for prevention of neonatal infection. The total execution time for the three scenarios was 40 minutes. The simulation created immersive virtual reality experiences using a head-mounted display with hand-tracking technology. Data were collected from December 9, 2019, to January 17, 2020, and were analyzed using descriptive statistics and the t-test, paired t-tests, Mann-Whitney test and Wilcoxon signed-ranks test. Results: Compared to the control group, the experimental group showed significantly greater improvements in high-risk neonatal infection control performance self-efficacy (t = _2.16, p = .018) and learner satisfaction (t = _5.59, p < .001). Conclusion: The virtual reality simulation program can expand the nursing students’ practice experience in safe virtual spaces and enhance their performance self-efficacy and learning satisfaction.
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Anticancer Drug-Loaded Gliadin Nanoparticles Induce Apoptosis in Breast Cancer Cells
Gulfam, Muhammad,Kim, Ji-eun,Lee, Jong Min,Ku, Boram,Chung, Bong Hyun,Chung, Bong Geun American Chemical Society 2012 Langmuir Vol.28 No.21
<P>Nanoscale drug carriers play an important role in regulating the delivery, permeability, and retention of the drugs. Although various carriers have been used to encapsulate anticancer drugs, natural biomaterials are of great benefit for delivery and controlled release of drugs. We used the electrospray deposition system to synthesize gliadin and gliadin-gelatin composite nanoparticles for delivery and controlled release of an anticancer drug (e.g., cyclophosphamide). The size profile and synthesis of nanoparticles was characterized by dynamic light scattering and X-ray diffractometry. Cyclophosphamide was gradually released from the gliadin nanoparticles for 48 h. In contrast, the gliadin-gelatin composite nanoparticles released cyclophosphamide in a rapid manner. Furthermore, we demonstrated that breast cancer cells cultured with cyclophosphamide-loaded 7% gliadin nanoparticles for 24 h became apoptotic, confirmed by Western blotting analysis. Therefore, the gliadin-based nanoparticle could be a powerful tool for delivery and controlled release of anticancer drugs.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/langd5/2012/langd5.2012.28.issue-21/la300691n/production/images/medium/la-2012-00691n_0008.gif'></P>
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