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An insulin-sensing sugar-based fluorescent hydrogel
Bhuniya, Sankarprasad,Kim, Byeang Hyean Royal Society of Chemistry 2006 Chemical communications Vol.2006 No.17
<P>We have prepared a small library of amphiphiles, each comprising a polar carbohydrate head group attached through an N-terminal amino acid to a nonpolar pyrene tail group. One of these derivatives is sensitive to the presence of insulin in aqueous media.</P> <P>Graphic Abstract</P><P>A small library of amphiphiles consisting of a polar carbohydrate “headgroup” attached to the N-termini of amino acids, which is linked with a nonpolar pyrene tail group have been prepared and it is found that one of them has insulin sensitivity in aqueous media. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=b516632b'> </P>
Diagnostic Significance of pH-Responsive Gd<sup>3+</sup>-Based T<sub>1</sub> MR Contrast Agents
Bhuniya, Sankarprasad,Hong, Kwan Soo Korean Society of Magnetic Resonance in Medicine 2019 Investigative Magnetic Resonance Imaging Vol.23 No.1
We discuss recent advances in Gd-based $T_1$-weighted MR contrast agents for the mapping of cellular pH. The pH plays a critical role in various biological processes. During the past two decades, several MR contrast agents of strategic importance for pH-mapping have been developed. Some of these agents shed light on the pH fluctuation in the tumor microenvironment. A pH-responsive self-assembled contrast agent facilitates the visualization of tumor size as small as $3mm^3$. Optimization of various parameters is crucial for the development of pH-responsive contrast agents. In due course, the new contrast agents may provide significant insight into pH fluctuations in the human body.
Bhuniya, Sankarprasad,Lee, Min Hee,Jeon, Hyun Mi,Han, Ji Hye,Lee, Jae Hong,Park, Nayoung,Maiti, Sukhendu,Kang, Chulhun,Kim, Jong Seung The Royal Society of Chemistry 2013 Chemical communications Vol.49 No.64
<P>We present the design, synthesis, optical properties and <I>in vitro</I> biological assessments of the theranostic prodrug <B>6</B> in which a near IR fluorophore is conjugated with a cancer cell-directing biotin unit; further it is linked with the anti-cancer drug gemcitabine <I>via</I> a self-immolative spacer, a disulfide bond. The prodrug <B>6</B> is able to monitor drug delivery and cellular imaging.</P> <P>Graphic Abstract</P><P>We developed a bifunctional theranostic prodrug that instantaneously monitors target specific delivery of gemcitabine and cellular imaging by the action of cellular enzyme. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c3cc42653j'> </P>
Diagnostic Significance of pH-Responsive Gd3+-Based T1 MR Contrast Agents
Sankarprasad Bhuniya,홍관수 대한자기공명의과학회 2019 Investigative Magnetic Resonance Imaging Vol.23 No.1
We discuss recent advances in Gd-based T1-weighted MR contrast agents for the mapping of cellular pH. The pH plays a critical role in various biological processes. During the past two decades, several MR contrast agents of strategic importance for pH-mapping have been developed. Some of these agents shed light on the pH fluctuation in the tumor microenvironment. A pH-responsive self-assembled contrast agent facilitates the visualization of tumor size as small as 3 mm3. Optimization of various parameters is crucial for the development of pH-responsive contrast agents. In due course, the new contrast agents may provide significant insight into pH fluctuations in the human body.
ON NOETHERIAN PSEUDO-PRIME SPECTRUM OF A TOPOLOGICAL LE-MODULE
Anjan Kumar Bhuniya,Manas Kumbhakar Korean Mathematical Society 2023 대한수학회논문집 Vol.38 No.1
An le-module M over a commutative ring R is a complete lattice ordered additive monoid (M, ⩽, +) having the greatest element e together with a module like action of R. This article characterizes the le-modules <sub>R</sub>M such that the pseudo-prime spectrum X<sub>M</sub> endowed with the Zariski topology is a Noetherian topological space. If the ring R is Noetherian and the pseudo-prime radical of every submodule elements of <sub>R</sub>M coincides with its Zariski radical, then X<sub>M</sub> is a Noetherian topological space. Also we prove that if R is Noetherian and for every submodule element n of M there is an ideal I of R such that V (n) = V (Ie), then the topological space X<sub>M</sub> is spectral.
A DTTA-ligated uridine–quantum dot conjugate as a bimodal contrast agent for cellular imaging
Park, Junwon,Bhuniya, Sankarprasad,Lee, Hyunseung,Noh, Young-Woock,Lim, Yong Taik,Jung, Jong Hwa,Hong, Kwan Soo,Kim, Jong Seung The Royal Society of Chemistry 2012 Chemical communications Vol.48 No.26
<P>A uridine–quantum dot conjugate, a contrast agent for multimodal imaging, was synthesized. Its <I>T</I><SUB>1</SUB> relaxivity was 655 and 571.2 mM<SUP>−1</SUP> s<SUP>−1</SUP> per particle at 36 °C in phosphate buffered saline at 60 and 200 MHz, respectively. <I>In vitro</I> multimodal images confirmed its uptake by RAW 264.7 cells.</P> <P>Graphic Abstract</P><P>A uridine–quantum dot conjugate, a multimodal imaging agent was synthesized with high <I>T</I><SUB>1</SUB> relaxivity. This bimodal (MR/FR) nanoprobe used as cellular labeling of phagocyte cell. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c2cc17555j'> </P>
Fluorescence turn-on sensors for HSO<sub>4</sub><sup>−</sup>
Kim, Hyun Jung,Bhuniya, Sankarprasad,Mahajan, Rakesh Kumar,Puri, Rajiv,Liu, Hongguang,Ko, Kyoung Chul,Lee, Jin Yong,Kim, Jong Seung The Royal Society of Chemistry 2009 Chemical communications Vol.2009 No.46
<P>A coumarin-based derivative (1), a highly selective and sensitive turn-on fluorogenic probe for the detection of HSO4- ions in aqueous solution, has been designed and synthesized. Various spectroscopic and DFT calculations revealed that H-bonding between the phenolic -OH and imine nitrogen of 1 played a crucial role in its high selectivity for HSO4-.</P>
Kim, Eun-Joong,Bhuniya, Sankarprasad,Lee, Hyunseung,Kim, Hyun Min,Shin, Weon Sup,Kim, Jong Seung,Hong, Kwan Soo American Chemical Society 2016 ACS APPLIED MATERIALS & INTERFACES Vol.8 No.16
<P>A novel dual imaging probe for in vivo magnetic resonance imaging (MRI) and optical imaging was developed by combining gadolinium (Gd)-chelating MR probe and a near-infrared (NIR) fluorophore, aza-BODIPY (AB; BODIPY = boron-dipyrromethene). This aza-BODIPY-based bimodal contrast agent (AB-BCA) showed a significant fluorescence emission around the NIR range and an enhanced longitudinal relaxivity in MR modality. The probe was easily delivered to phagocytic cells of the innate immune system, together with macrophages and dendritic cells (DCs), and presented high-performance fluorescence and MR imaging without obvious cytotoxicity. For in vivo visualization of AB-BCA using MRI and optical imaging, bone marrow derived DCs were labeled and injected into the footpad of mice, and labeled DCs were tracked in vivo. We observed the migration of AB-BCA-labeled DCs into the lymph nodes via lymphatic vessels using NIR fluorescence and T-1-weighted MR images. This dual-modality imaging probe was used for noninvasive monitoring of DC migration into lymph nodes and could be useful for investigating advanced cellular immunotherapy.</P>