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Bhatia Kailash,Eccles Jennifer,Meessala Dinesh. K 대한마취통증의학회 2021 Korean Journal of Anesthesiology Vol.74 No.4
Background: Shone’s syndrome is a rare complex congenital cardiac condition, characterized by a supra-valvular mitral ring, parachute deformity of the mitral valve, aortic stenosis, and coarctation of the aorta.Case: A 26-year-old parturient with partial Shone’s syndrome presented to our delivery unit in pulmonary edema. She underwent a scheduled cesarean section performed under a combined spinal-epidural anesthetic at 33 weeks. She had multidisciplinary input from the cardiac, obstetric, and anesthetic teams, which led to a good outcome. A review of the five published case reports of Shone’s syndrome in pregnancy is presented along with key findings.Conclusions: Our case report and the review highlight the successful use of combined spinal-epidural anesthetic and provides guidance to the multidisciplinary team on the varied presentation and the optimum management of women with Shone’s syndrome during the peripartum period.
Arvind Lal Bhatia,Kailash Manda,Shikha Patni,Antim Lata Sharma 한국식품영양과학회 2006 Journal of medicinal food Vol.9 No.2
The present study is a pilot study that explores the antioxidative properties of linseed (Linum usitatissimum)oil in its prophylactic action against oxidative stress induced by a radiomimetic drug, cyclophosphamide. Oral administrationof linseed oil (0.1 mL/kg of body weight/day) for 20 days prior to an acute dose of cyclophosphamide (75 mg/kg) signifi-cantly inhibited the augmented level of malondialdehyde, conjugated dienes, and hydroperoxides in the mouse brain. The cy-clophosphamide-induced decline in the levels of reduced glutathione, glutathione peroxidase, and alkaline phosphatase wasalso significantly prevented by linseed oil in mouse blood. Similarly, the increased activity of acid phosphatase and oxidizedglutathione was significantly inhibited by linseed oil. Results clearly indicate the prophylactic action of linseed oil against cy-clophosphamide-induced oxidative stress.