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초음파 유도 가열 기반 가속된 용질성 마랑고니 유동을 이용한 미세 액적 혼합
차범석(Beomseok Cha),김우혁(Woohyuk Kim),윤기성(Giseong Yoon),전현우(Hyunwoo Jeon),박진수(Jinsoo Park) 대한기계학회 2021 대한기계학회 춘추학술대회 Vol.2021 No.11
In digital microfluidics, droplet-based technology has inherent limitation of the quiescent flow condition at low Reynolds number, which causes mixing samples confined within the droplets to be challenging. Recently, solutal Marangoni-driven vortical flows have emerged as a promising approach for digital microfluidic mixing. Despite its simplicity, the solutal Marangoni effect still demands a long time for sample mixing, which makes it difficult to be utilized for practical engineering applications. Here, we propose a new digital microfluidic mixing method by accelerated solutal Marangoni flows in liquid sessile drops based on improved ultrasound-induced heating device. We theoretically and experimentally investigated the accelerated Marangoni flow and confirmed that droplet mixing can be achieved within a few seconds even for high viscosity liquids. The proposed heater-embedded droplet mixing platform can be fabricated in small size, allowing it to be integrated with other microfluidic platforms. We believe that the proposed droplet mixing platform can be utilized for a variety of practical applications in bioassays, clinical diagnostics, and drug screening.
박경민(Gyeongmin Park),차범석(Beomseok Cha),박진수(Jinsoo Park) 대한기계학회 2022 대한기계학회 춘추학술대회 Vol.2022 No.11
In the development of biochemical technology, microfluidic-based microreaction technology has provided a variety of useful platforms, and extensive research on microreactor-based tools has demonstrated their benefits. The acoustic microfluidic-based microreactor proposed in this study uses surface acoustic waves to generate a vortex of the fluid called acoustic streaming flow in a non-contact manner. This device can be used as a way to solve the problems of sample contamination and activity degradation by preventing direct contact of samples by replacing existing reactor systems. It also consumes small amount of samples and enables real-time analysis on the microscopic stage simultaneously. In this research, we experimentally proved the validity of this device by E-Coli cell culture and Gold Nanoparticles(AuNPs) synthesis. We believe that the proposed microreactor can be utilized for a variety of applications in the biochemical field including disease diagnosis and drug screening.
박경민(Gyeongmin Park),차범석(Beomseok Cha),박진수(Jinsoo Park) 대한기계학회 2022 대한기계학회 춘추학술대회 Vol.2022 No.11
In the development of biochemical technology, microfluidic-based microreaction technology has provided a variety of useful platforms, and extensive research on microreactor-based tools has demonstrated their benefits. The acoustic microfluidic-based microreactor proposed in this study uses surface acoustic waves to generate a vortex of the fluid called acoustic streaming flow in a non-contact manner. This device can be used as a way to solve the problems of sample contamination and activity degradation by preventing direct contact of samples by replacing existing reactor systems. It also consumes small amount of samples and enables real-time analysis on the microscopic stage simultaneously. In this research, we experimentally proved the validity of this device by E-Coli cell culture and Gold Nanoparticles(AuNPs) synthesis. We believe that the proposed microreactor can be utilized for a variety of applications in the biochemical field including disease diagnosis and drug screening.
박정은(Jeongeun Park),강효찬(Hyochan Kang),강예슬(Yeseul Kang),차범석(Beomseok Cha),박진수(Jinsoo Park) 대한기계학회 2023 대한기계학회 춘추학술대회 Vol.2023 No.11
Acoustomicrofluidic chips are being applied in various fields, including drug screening, because of their ability to control microscale heat transfer and manipulate floating objects. Acoustomicrofluidic chips can be used as disposable by attaching a PDMS film underneath the channel instead of permanently attaching an electrode and a channel. This approach is considered cost-effective and helps prevent contamination of channels. However, the conversion of acoustic energy into thermal energy occurs as a result of absorption caused by the viscoelasticity of PDMS. This phenomenon leads to changes in the properties of the fluid or particles. Therefore, a quantitative analysis of the absorption of acoustic waves by PDMS is necessary. This study investigates the relationship between the absorption characteristics and the thickness of the PDMS membrane through thermal measurement experiments using an infrared camera. This is validated by the results of flow mixing using acoustic streaming flow.