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RISS 인기검색어
- 검색키워드
- 저자 : Benoist, Henri Michel (검색결과 6 건)
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Profile of chronic and aggressive periodontitis among Senegalese
Benoist, Henri Michel,Seck-Diallo, Adam,Diouf, Abdoulaye,Yabbre, Salama,Sembene, Malick,Diallo, Papa Demba Korean Academy of Periodontology 2011 Journal of Periodontal & Implant Science Vol.41 No.6
Purpose: To describe the profile of chronic and aggressive periodontitis among Senegalese (West Africans) attending the Institute of Dentistry of Dakar. Methods: A retrospective study was conducted with an inclusion period running from 2001 to 2008. The sample included 413 chronic periodontitis and 151 aggressive periodontitis cases, among them 299 males and 265 females selected from 2,274 records. A Student's independent t-test or Pearson chi-squared test was used for data analysis. Results: The proportion of females with aggressive periodontitis was significantly higher than those with chronic periodontitis (64.9% vs. 40.4%, P<0.001). The aggressive periodontitis patients had an average age of $28.1{\pm}8.9$ years, and had lost less than 3 teeth. Less than a third of them reported using a toothbrush. Attachment loss was as high as 8 mm and severe lesions had spread to an average of 12 teeth with maximum alveolar bone loss up to 80%. The chronic periodontitis patients had an average age of $44.9{\pm}14.0$ and had lost on average less than 3 teeth. Nearly 75% used a toothbrush. Attachment loss was significantly higher and lesions were more extensive in the aggressive periodontitis. Chronic periodontitis is associated with risk factors such as smoking or diabetes mellitus in 12.8% versus 0.7% in aggressive periodontitis (P<0.001). Differences between the two groups for most clinical and radiographic parameters were statistically significant. Conclusions: The profile of aggressive periodontist is characterized by more severe lesions than chronic periodontitis, whereas tooth loss experience is similar in both forms.
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Profile of chronic and aggressive periodontitis among Senegalese
Henri Michel Benoist,Adam Seck-Diallo,Abdoulaye Diouf,Salama Yabbre,Malick Sembene,Papa Demba Diallo 대한치주과학회 2011 Journal of Periodontal & Implant Science Vol.41 No.6
Purpose: To describe the profile of chronic and aggressive periodontitis among Senegalese (West Africans) attending the Institute of Dentistry of Dakar. Methods: A retrospective study was conducted with an inclusion period running from 2001 to 2008. The sample included 413chronic periodontitis and 151 aggressive periodontitis cases, among them 299 males and 265 females selected from 2,274 records. A Student’s independent t-test or Pearson chi-squared test was used for data analysis. Results: The proportion of females with aggressive periodontitis was significantly higher than those with chronic periodontitis (64.9% vs. 40.4%, P<0.001). The aggressive periodontitis patients had an average age of 28.1±8.9 years, and had lost less than 3 teeth. Less than a third of them reported using a toothbrush. Attachment loss was as high as 8 mm and severe lesions had spread to an average of 12 teeth with maximum alveolar bone loss up to 80%. The chronic periodontitis patients had an average age of 44.9±14.0 and had lost on average less than 3 teeth. Nearly 75% used a toothbrush. Attachment loss was significantly higher and lesions were more extensive in the aggressive periodontitis. Chronic periodontitis is associated with risk factors such as smoking or diabetes mellitus in 12.8% versus 0.7% in aggressive periodontitis (P<0.001). Differences between the two groups for most clinical and radiographic parameters were statistically significant. Conclusions: The profile of aggressive periodontist is characterized by more severe lesions than chronic periodontitis, whereas tooth loss experience is similar in both forms.
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Aire's plant homeodomain(PHD)-2 is critical for induction of immunological tolerance.
Yang, Siyoung,Bansal, Kushagra,Lopes, Jared,Benoist, Christophe,Mathis, Diane National Academy of Sciences 2013 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.110 No.5
<P>Aire impacts immunological tolerance by regulating the expression of a large set of genes in thymic medullary epithelial cells, thereby controlling the repertoire of self-antigens encountered by differentiating thymocytes. Both humans and mice lacking Aire develop multiorgan autoimmunity. Currently, there are few molecular details on how Aire performs this crucial function. The more amino-terminal of its two plant homeodomains (PHDs), PHD1, helps Aire target poorly transcribed loci by 'reading' the methylation status of a particular lysine residue of histone-3, a process that does not depend on the more carboxyl-terminal PHD-2. This study addresses the role of PHD2 in Aire function by comparing the behavior of wild-type and PHD2-deleted Aire in both transfected cells and transgenic mice. PHD2 was required for Aire to interact with sets of protein partners involved in chromatin structure/binding or transcription but not with those implicated in pre-mRNA processing; it also was not required for Aire's nuclear translocation or regional distribution. PHD2 strongly influenced the ability of Aire to regulate the medullary epithelial cell transcriptome and so was crucial for effective central tolerance induction. Thus, Aire's two PHDs seem to play distinct roles in the scenario by which it assures immunological tolerance.</P>
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Regulatory T cells generated early in life play a distinct role in maintaining self-tolerance
Yang, Siyoung,Fujikado, Noriyuki,Kolodin, Dmitriy,Benoist, Christophe,Mathis, Diane American Association for the Advancement of Scienc 2015 Science Vol.348 No.6234
<P><B>Early T cells keep autoimmunity at bay</B></P><P>A major challenge faced by the immune system is to react to foreign substances, such as microbes, while simultaneously tolerating the self. Upsetting this balance leads to autoimmunity. Regulatory T cells (T<SUB>regs</SUB>), are a subset of immune cells that help to maintain this balance. Yang <I>et al.</I> found that murine T<SUB>reg</SUB> cells generated very early in life are distinct from those generated in older animals and play an especially important role in keeping autoimmunity in check (see the Perspective by Tanaka and Sakaguchi). These changes are due to differences in the way T<SUB>regs</SUB> develop in the thymus in newborn versus adult mice.</P><P><I>Science</I>, this issue p. 589; see also p. 506</P><P>Aire is an important regulator of immunological tolerance, operating in a minute subset of thymic stromal cells to induce transcripts encoding peptides that guide T cell selection. Expression of Aire during a perinatal age window is necessary and sufficient to prevent the multiorgan autoimmunity characteristic of Aire-deficient mice. We report that Aire promotes the perinatal generation of a distinct compartment of Foxp3<SUP>+</SUP>CD4<SUP>+</SUP> regulatory T (T<SUB>reg</SUB>) cells, which stably persists in adult mice. This population has a role in maintaining self-tolerance, a transcriptome and an activation profile distinguishable from those of T<SUB>regs</SUB> produced in adults. Underlying the distinct T<SUB>reg</SUB> populations are age-dependent, Aire-independent differences in the processing and presentation of thymic stromal-cell peptides, resulting in different T cell receptor repertoires. Our findings expand the notion of a developmentally layered immune system.</P>
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