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RISS 인기검색어
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- 저자 : Baohui Li (검색결과 5 건)
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Li Li,Huan Liu,Boya Li,Yanan Guo,Liming Qing,Baohui Wang 한국고분자학회 2020 Macromolecular Research Vol.28 No.5
The polyaniline/reduced graphene oxide (PANI/RGO) modified interdigital electrode (IDE) has been successfully fabricated by in situ electrochemical reduction and electrochemical polymerization through cyclic voltammetry. The morphology and topography of PANI/RGO characterized by SEM and AFM display intercrosslinked dendritic structure in three dimensions, and it is favorable for the detection of nitrite due to its large surface area, which can provide the large electrocatalytic active surface and various diffusion paths for nitrite. Herein, the obtained PANI/ RGO/IDE was employed for the electrochemical monitoring platform of nitrite for the first time and the electrochemical performance of the as-developed sensor was investigated via cyclic voltammetry and chronoamperometry. At the optimum conditions, the PANI/RGO/IDE has a linear response in the range from 0.4 to 183.7 mM with a sensitivity of 457.4 μA mM-1 cm-2 and a detection limit of 0.1 μM. Moreover, the obtained PANI/RGO/IDE with excellent long-term stability and reproducibility also can be employed for practical application for the determination of nitrite in tap water, the results show that the recovery rate is desirable. It is expected that IDE can be employed as the substrate electrode decorated with various materials to construct highperformance electrochemical sensors.
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Research on Bending Stiffness of the New Sprayer Joint
Ren Li,Zhicheng Xiao,Hui-jun Li,Baohui Li 한국강구조학회 2024 International Journal of Steel Structures Vol.24 No.2
The socket joint are commonly employed in large-span spatial structures; however, its bending stiff ness is limited. Based on the socket joint, this paper proposes an improved and novel sprayer joint that features a more rational force transmission mechanism and have larger bending stiff ness. Firstly, the joint is designed, followed by verifi cation of numerical model and bending stiff ness comparison with socket joint. Secondly, the bending performance of the sprayer joints with various surrounding bolt radii under load conditions is investigated, and the resulting bending moment-rotation curves are obtained. The research fi ndings demonstrate that the force transmission mechanism of the sprayer joint with larger bending stiff ness is more rational. When the surrounding bolt radius is excessively small or the axial tension is excessively high, the bolt prematurely yields, leading to a signifi cant decrease in joint stiff ness. Despite a mere 15% increase in material cost, the bending stiff ness of the new joint is 21.71 times higher than that of the traditional socket joint, and the ultimate bending moment is 5.42 times higher.
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Potential Antitumor Activity of SIM-89 in Non-Small Cell Lung Cancer Cells
Jun Pei,Baohui Han,Tianqing Chu,Minhua Shao,Jiajun Teng,Huifang Sha,Aiqing Gu,Rong Li,Jialin Qian,Weifeng Mao,Ying Li 연세대학교의과대학 2017 Yonsei medical journal Vol.58 No.3
Purpose: c-Met and its ligand, hepatocyte growth factor (HGF), play a critical role in oncogenesis and metastatic progression. The aim of this study was to identify inhibited enzymogram and to test the antitumor activity of SIM-89 (a c-Met receptor tyrosine kinaseinhibitor) in non-small cell lung cancer. Materials and Methods: Z’-LYTE kinase assay was employed to screen the kinase enzymogram, and mechanism of action (MOA) analysis was used to identify the inhibited kinases. Cell proliferation was then analyzed by CCK8 assay, and cell migration was determinedby transwell assay. The gene expression and the phosphorylation of c-Met were examined by realtime-PCR and western blotting, respectively. Finally, the secretion of HGF was detected by ELISA assay. Results: c-Met, activated protein kinase (AMPK), and tyrosine kinase A (TRKA) were inhibited by SIM-89 with the IC50 values of 297 nmol/L, 1.31 μmol/L, and 150.2 nmol/L, respectively. SIM-89 exerted adenosine triphosphate (ATP) competitive inhibition on c-Met. Moreover, the expressions of STAT1, JAK1, and c-Met in H460 cells were decreased by SIM-89 treatment, and c-Met phosphorylationwas suppressed in A549, H441, H1299, and B16F10 cells by the treatment. In addition, SIM-89 treatment significantly decreased the level of HGF, which accounted for the activation of c-Met receptor tyrosine kinase. Finally, we showed cell proliferationinhibition and cell migration suppression in H460 and H1299 cells after SIM-89 treatment. Conclusion: In conclusion, SIM-89 inhibits tumor cell proliferation, migration and HGF autocrine, suggesting it’s potential antitumoractivity.
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Zhentao Guo,Qianxue Chen,Baohui Liu,Daofeng Tian,Shenqi Zhang,Mingchang Li 연세대학교의과대학 2014 Yonsei medical journal Vol.55 No.5
Purpose: Leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) are an inhibitor of receptor tyrosine kinases (RTKs) that was discovered in recent years, and many studies showed that LRIG1 is a tumor suppressor gene and may be related to tumor drug resistance. In this study, we explored whether LRIG1 protein expression can improve the chemosensitivity of glioma cells and what was its mechanism. Materials and Methods: We collected 93 cases of glioma tissues and detected the expression of LRIG1 and BCL-2. We constructed a multidrugresistance cell line U251/multidrug resistance (MDR) and examined the change of LRIG1 and BCL-2 at mRNA and protein expression levels. LRIG1 expressionwas upregulated in U251/MDR cells and we detected the change of multidrug resistance. Meanwhile, we changed the expression of LRIG1 and BCL-2 and explored the relationship between LRIG1 and BCL-2. Finally, we also explored the relationship between LRIG1 and RTKs. Results: LRIG1 was negatively correlated with BCL-2 expression in glioma tissue and U251/MDR cells, and upregulation of LRIG1 can enhance chemosensitivity and inhibit BCL-2 expression. Furthermore, LRIG1 was negatively correlated with RTKs in U251/MDR cells. Conclusion: These results demonstrated that LRIG1 can improvechemosensitivity by modulating BCL-2 expression and RTK signaling in glioma cells.
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