Antioxidant Flavone Glycosides from the Root of Pteroxygonum giraldii

Li, Bao-Lin,Yang, Zhan-Jun,Jiang, Lin-Ling,Zhang, Xi-Quan,Gu, Hong-Mei,Wang, Hui-Chun,Tian, Xian-Hua Korean Chemical Society 2009 Bulletin of the Korean Chemical Society Vol.30 No.7

Two new flavone glycosides, giraldiin A and B, together with three known compounds, annulatin, myricetin 3-O-$\alpha$- L-rhamnopyranoside and gallic acid, were isolated from the ethanol extract of the root of Pteroxygonum giraldii Damm. et Diels. The structures of giraldiin A and B are designated as 3'-($\alpha$-L-arabinopyranosyloxy)-4',5,5',7- tetrahydroxy-3-methoxyflavone and 4'-($\beta$-D-glucopyranosyloxy)-5,5',7-trihydroxy-2',3-dimethoxyflavone, respectively, on the basis of detailed spectroscopic analyses. The free radical scavenging activity of giraldiin A was evaluated by decolouring spectrophotometry of pentamethine cyanine dye (Cy5) with $Fe^{2+}-H_2O_2$ Fenton radical generating system. The results indicated the hydroxyl free radical scavenging activity of giraldiin A (E$D_{50}$ = 23.7 nmol/mL) is higher than that of some known antioxidants such as rutin, puerarin, daidzein and 2,6-di-tertbutyl-4-methylphenol.

Stereochemistry Structure of Odonicin

Li, Bao-Lin,Li, Jin,Tong, Ling,Pan, Yuan-Jiang,Yu, Kai-Bei Korean Chemical Society 2004 Bulletin of the Korean Chemical Society Vol.25 No.2

miR-29 family inhibited the proliferation and migration of lung cancer cells by targeting SREBP-1

Lin Lin,Bao Yongxia,Tian Miao,Ren Qiu,Zhang Wei 대한독성 유전단백체 학회 2022 Molecular & cellular toxicology Vol.18 No.2

Backgrounds Lipid metabolism dysregulation is an important characteristic of tumor cells. Increased lipid metabolism provides a vital material and energy source for tumor growth, thereby promoting tumor invasion and metastasis. Objectives In the current work, we carried out a series of in vivo and in vitro studies to explore the relationship between miR-29 and lung cancer. Results The results showed that miR-29 was down-regulated in lung cancer, and overexpression of miR-29 inhibited the proliferation and migration of lung cancer cells (in vitro). Anti-lung cancer effect of miR-29 in vivo was evaluated, and results indicated that transfection of miR-29b/c markedly inhibited lung tumor growth (in vivo). We further explored the potential mechanism by which miR-29 could inhibit the cell proliferation of lung cancer. It is well known that lipid metabolism dysregulation is an important characteristic of tumor cells. Increased lipid metabolism provides a vital material and energy source for tumor growth, thereby promoting tumor invasion and metastasis, and sterol regulatory element-binding protein 1 (SREBP) is involved in liposome metabolism. Therefore, we analyzed the interaction between miR-29C and SREBP-1 in lung cancer cells. Bioinformatics analysis showed that the miR-29 has the potential binding site on SCAP and SREBP mRNA, and Luciferase reporter gene assays revealed the interaction between 3′UTR of SREBP-1 mRNA and miR-29c. Further study showed that miR-29 suppressed (SREBP-1) expression by interacting with 3′UTR of SREBP-1. Further work indicated that miR-29 transfection strongly inhibited lung cancer cell proliferation, which was rescued by the overexpression of SREBP-1. Conclusion These fi ndings demonstrate that transfection of miR-29 suppressed lung cancer proliferation via inhibiting SREBP-1 expression. The current study provides a basis for exploring the targeted agents against lung cancer.

Diagnostic Value of Human Epididymis Protein 4 Compared with Mesothelin for Ovarian Cancer: a Systematic Review and Meta-analysis

Lin, Jia-Ying,Qin, Jin-Bao,Li, Xiao-Yan,Dong, Ping,Yin, Bing-De Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.11

Background and Purpose: Ovarian cancer is the leading cause of death among gynecologic cancers because of the lack of effective early detection methods. Accuracies of the human epididymis protein 4 (HE4) and mesothelin in detecting ovarian cancer have never been systematically assessed. The current systematic review aimed to tackle this issue. Methods: MEDLINE, EMBASE, and Cochrane databases were searched (September 1995-November 2011) for studies on the diagnostic performances of HE4 and mesothelin in differentiating ovarian cancer from other benign gynecologic diseases. QUADAS items were used to evaluate the qualities of the studies. Meta-DiSc software was used to handle data from the included studies and to examine heterogeneity. All included studies for diagnostic performance were combined with sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratios (DORs) with 95% confidence intervals (CIs), summary receiver operating characteristic (SROC) curves, and areas under the SROC curves (AUC). Results: A total of 18 studies and 3,865 patients were eligible for the final analysis. The pooled sensitivity estimates for HE4 (74.4%) were significantly higher than those for mesothelin (49.3%). The pooled specificity estimates for mesothelin (94.5%) were higher than those for HE4 (85.8%). The pooled DOR estimates for HE4 (26.22) were higher than those for mesothelin (24.01). The SROC curve for HE4 showed better diagnostic accuracy than that for mesothelin. The PLR and NLR of HE4 were 6.33 (95% CI: 3.58 to 11.18) and 0.27 (95% CI: 0.21 to 0.34), respectively. The PLR and NLR for mesothelin were 11.0 (95% CI: 6.21 to 19.59) and 0.51 (95% CI: 0.42 to 0.62), respectively. The combination of the two tumor markers or their combination with CA-125 increased sensitivity and specificity to different extents. Conclusion: The diagnostic accuracy of HE4 in differentiating ovarian cancer from other benign gynecologic diseases is better than that of soluble mesothelin-related protein. Combinations of two or more tumor markers show more sensitivity and specificity.

A New Diterpenoid Isolated from Isodon japonica Structure Elucidation by NMR Spectroscopy

Li, Bao-Lin,Pan, Yuan-Jiang Korean Chemical Society 2002 Bulletin of the Korean Chemical Society Vol.23 No.4

A Base Promoted Synthesis of N,N-dimethylformamidines

Li, Bao Lin,Ding, Si Yi,Ren, Yu Fei,Wang, Liu Chang,Jia, Yu Cai,Zhang, Xi Quan,Gu, Hong Mei Korean Chemical Society 2013 Bulletin of the Korean Chemical Society Vol.34 No.5

A MODEL-ORDER REDUCTION METHOD BASED ON KRYLOV SUBSPACES FOR MIMO BILINEAR DYNAMICAL SYSTEMS

Lin, Yiqin,Bao, Liang,Wei, Yimin 한국전산응용수학회 2007 Journal of applied mathematics & informatics Vol.25 No.1

In this paper, we present a Krylov subspace based projection method for reduced-order modeling of large scale bilinear multi-input multi-output (MIMO) systems. The reduced-order bilinear system is constructed in such a way that it can match a desired number of moments of multi-variable transfer functions corresponding to the kernels of Volterra series representation of the original system. Numerical examples report the effectiveness of this method.

Geographic Distribution and Epidemiology of Lung Cancer During 2011 in Zhejiang Province of China

Lin, Xia-Lu,Chen, Yan,Gong, Wei-Wei,Wu, Zhao-Fan,Zou, Bao-Bo,Zhao, Jin-Shun,Gu, Hua,Jiang, Jian-Min Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.13

Background: To explore etiology for providing scientific clues for the prevention of lung cancer. Materials and Methods: Data for lung cancer incidence and meteorological geographic factors from 25 counties in Zhejiang province of China during 2011 were studied. Stepwise multiple regression and correlation analysis were performed to analyze the geographic distribution and epidemiology of lung cancer. Results: 8,291 new cases (5,998 in males and 2,293 females) of lung cancer during 2011 in Zhejiang province were reported in the 25 studied counties. Reported and standardized incidence rates for lung cancer were 58.0 and 47.0 per 100,000 population, respectively. The incidence of lung cancer increased with age. Geographic distribution analysis shows that the standardized incidence rates of lung cancer in northeastern Zhejiang province were higher than in the southwestern part, such as in Nanhu, Fuyang, Wuxing and Yuyao counties, where the rates were more than 50 per 100,000 population. In the southwestern Zhejiang province, for instance, in Yueqing, Xianju and Jiande counties, the standardized incidence rates of lung cancer were lower than 37 per 100,000 population. Spearman correlation tests showed that forest coverage rate, air quality index (AQI), and annual precipitation level are associated with the incidence of lung cancer. Conclusions: Lung cancer in Zhejiang province shows obvious regional differences. High incidence appears associated with low forest coverage rate, poor air quality and low annual precipitation. Therefore, increasing the forest coverage rate and controlling air pollution may play an important role in lung cancer prevention.

Size effects of the bending stiffness of nanowires

Li, Xian-Fang,Wang, Bao-Lin,Lee, Kang Yong American Institute of Physics 2009 JOURNAL OF APPLIED PHYSICS - Vol.105 No.7

<P>This paper studies the size effect in the transverse deformation of nanowires or nanoropes subjected to flexural bending. Based on the classic strain-gradient theory, a continuum approach is proposed, in which the strain energy was expressed in terms of the linear strains and strain gradients, and two additional phenomenological internal parameters were introduced. The governing equation for the flexural deformation of the nanowires was derived according to the principle of minimum potential energy. In particular, the deformations of the nanowires under two support conditions were determined explicitly, i.e., a cantilever nanowire and a fixed nanowire. Numerical examples were demonstrated to indicate the dependence of the effective modulus and bending stiffness upon the nanowire diameter and aspect ratio. The predictions given by the present model are consistent very well with the experimental measurements reported in the recent literature. The proposed model can be further used to explain the size effect in other properties of nanowires such as dynamics and thermal properties, among others. (C) 2009 American Institute of Physics. [DOI: 10.1063/1.3103322]</P>

An Analytical Solution for Voltage Stability Studies Incorporating Wind Power

Lin, Yu-Zhang,Shi, Li-Bao,Yao, Liang-Zhong,Ni, Yi-Xin,Qin, Shi-Yao,Wang, Rui-Ming,Zhang, Jin-Ping The Korean Institute of Electrical Engineers 2015 Journal of Electrical Engineering & Technology Vol.10 No.3

Voltage stability is one of the most critical security issues which has not yet been well resolved to date. In this paper, an analytical method called PQ plane analysis with consideration of the reactive power capability of wind turbine generator and the wake effect of wind farm is proposed for voltage stability study. Two voltage stability indices based on the proposed PQ plane analysis method incorporating the uncertainties of load-increasing direction and wind generation are designed and implemented. Cases studies are conducted to investigate the impacts of wind power incorporation with different control modes. Simulation results demonstrate that the constant voltage control based on reactive power capability significantly enhances voltage stability in comparison of the conventional constant power factor control. Some meaningful conclusions are obtained.