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Secular trends in cesarean sections and risk factors in South Korea (2006-2015)
( Ho Yeon Kim ),( Dokyum Lee ),( Jinsil Kim ),( Eunjin Noh Bachelor ),( Ki-hoon Ahn ),( Soon-cheol Hong ),( Hai-joong Kim ),( Min-jeong Oh ),( Geum Joon Cho ) 대한산부인과학회 2020 Obstetrics & Gynecology Science Vol.63 No.4
Objective This study aimed to investigate trends in the rate of cesarean sections (CSs) in South Korea from 2006 to 2015 and identify the risk factors associated with these changes. Methods Using the National Health Insurance Corporation dataset, all women who gave birth between 2006 and 2015 were included in the study. We investigated 1) the mode of delivery, 2) the complication rates during pregnancy (i.e., preeclampsia and placenta previa), and 3) pre-pregnancy factors (body mass index, hypertension [HTN], diabetes mellitus [DM], and other pre-existing medical conditions), and their trends during the study period. Results Over 10 years, the rate of CS increased from 36.3% in 2006 to 40.6% in 2015 (P<0.01). The rate of CS increased in primiparous women, women with multiple pregnancy, and women with preeclampsia. Maternal age and the incidence of placenta previa also increased. In contrast, the rate of vacuum deliveries and vaginal birth after CS decreased during the study period. The rate of women with pre-pregnancy obesity and DM increased, but the rate of women with pre-pregnancy HTN decreased. Conclusion The rate of CS in South Korea increased from 2006 to 2015. This trend may reflect changes in the rate of different risk factors. Identifying the causes of the increasing CS trend observed in this study will allow clinicians to monitor these factors and possibly reduce the rate of CS.
Strum, John S.,Nwosu, Charles C.,Hua, Serenus,Kronewitter, Scott R.,Seipert, Richard R.,Bachelor, Robert J.,An, Hyun Joo,Lebrilla, Carlito B. American Chemical Society 2013 ANALYTICAL CHEMISTRY - Vol.85 No.12
<P>Site-specific glycosylation (SSG) of glycoproteins remains a considerable challenge and limits further progress in the areas of proteomics and glycomics. Effective methods require new approaches in sample preparation, detection, and data analysis. While the field has advanced in sample preparation and detection, automated data analysis remains an important goal. A new bioinformatics approach implemented in software called GP Finder automatically distinguishes correct assignments from random matches and complements experimental techniques that are optimal for glycopeptides, including nonspecific proteolysis and high mass resolution liquid chromatography/tandem mass spectrometry (LC/MS/MS). SSG for multiple N- and O-glycosylation sites, including extensive glycan heterogeneity, was annotated for single proteins and protein mixtures with a 5% false-discovery rate, generating hundreds of nonrandom glycopeptide matches and demonstrating the proof-of-concept for a self-consistency scoring algorithm shown to be compliant with the target-decoy approach (TDA). The approach was further applied to a mixture of N-glycoproteins from unprocessed human milk and O-glycoproteins from very-low-density-lipoprotein (vLDL) particles.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancham/2013/ancham.2013.85.issue-12/ac4006556/production/images/medium/ac-2013-006556_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ac4006556'>ACS Electronic Supporting Info</A></P>
De Jong, Wim H.,Hoffmann, Sebastian,Lee, Michelle,Kandá,rová,, Helena,Pellevoisin, Christian,Haishima, Yuji,Rollins, Beau,Zdawczyk, Austin,Willoughby, Jamin,Bachelor, Michael,Schatz, Timot Elsevier 2018 Toxicology in vitro Vol.50 No.-
<P><B>Highlights</B></P> <P> <UL> <LI> Alternative in vitro testing of medical device extracts for irritation is possible. </LI> <LI> Reconstructed human epidermis (RhE) model detects presence of irritant in extracts. </LI> <LI> High predictivity RhE model for presence of strong irritants in material extracts. </LI> <LI> Predictivity in saline or sesame oil extract depends on hydrophilicity of irritant. </LI> <LI> Four positive polymer test materials containing a known irritant were evaluated. </LI> </UL> </P>