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Evaluation of Anti-inflammatory Activity of Asparagus racemosus Willd. (Liliaceae) root extract
Subhash C. Mandal,B. C. Maiti,Tapan K. Maity,M. Pal,B. P. Saha 한국생약학회 1998 Natural Product Sciences Vol.4 No.4
The methanol extract of Asparagus racemosus root was evaluated for its anti-inflammatory activity on carrageenin and serotonin-induced rat hind paw oedema models. The extract (200 and 400 ㎎/㎏) showed maximum inhibition of oedema of 18.6% and 33.7% at 3 h with carrageenin and 22.2% and 40.5% at 5 h with serotonin-induced rat paw oedema respectively. The experimental models tested, where the effect produced by the extract was compared to that of phenylbutazone, a prototype non-steroidal anti-inflammatory drug.
Veerendra C. Yeligar,K. Murugesh,Deepak Kumar Dash,Siva Shankar Nayak,B. C. Maiti,Tapan K. Maity 한국생약학회 2007 Natural Product Sciences Vol.13 No.1
unripe whole fruits of Luffa tuberosa (Roxb.) or Momordica tuberosa (Roxb) Cogn.(Cucurbitaceae) were evaluated for the antidiabetic and hyperlipidemic potential in streptozotocin (STZ) induceddiabetic rats. Diabetes was induced by administration of intra-peritoneal injection of streptozotocin at a dose of55 mg/kg body weight. After the induction of diabetes aqueous extract of L.tuberosa (AELT) was administeredorally at doses of 250 and 500 mg/kg. body weight/day for a period of 14 days. The Fasting blood glucose (FBG)levels, serum insulin levels, changes in body weight, food and liquid intake were measured. In diabetic rats, theAELT exhibited significant reduction in blood glucose levels. Biochemical assay of plasma total cholesterol (TC),triglyceride (TG), high-density lipoprotein cholesterol (HDLc), low-density lipoprotein cholesterol (LDLc),after the extract supplementation was confirmed by significant reduction in the levels of above mentionedhyperlipidemic indicators. This study focus on the efficacy of L.tuberosa fruits for the management ofexperimental STZ induced diabetic rats and provides the scientific basis of ancient herbal therapy and use of thesefruits as vegetable.KeywordsLuffa tuberosa (Roxb.), streptozotocin, antihyperglycemic activity, antihyperlipidemic activity
Evaluation of Hepatoprotective Potential of Cassia tora Leaf Extract
Maity, Tapan Kumar,Mandal, Subhash C.,Mukherjee, Pulok K.,Saha, Kakali,Das, J.,Saha, B.P.,Pal, M. The Korean Society of Pharmacognosy 1997 Natural Product Sciences Vol.3 No.2
Methanolic extract of the leaves of Cassia tom was evaluated for its hepatoprotective potentials in rats by inducing hepatotoxicity with carbon tetrachloride. The extract at a dose of 400 mg/kg orally showed significant protective effect by lowering the serum levels of transaminase (SGOT and SGPT), bilirubin and alkaline phosphatase (ALP). The effects produced were comparable to that of a standard hepatoprotective agent.
Subhash C. Mandal,Tapan K. Maity,J. Das,B. P. Saha,M. Pal 한국생약학회 1998 Natural Product Sciences Vol.4 No.3
The effect of oral treatment with Ficus racemosa leaf extract (400 ㎎/㎏ for seven days) were studied on hepatic damage induced by paracetamol (750 ㎎/㎏, i.p.) in rats. Biochemical parameter like SGOT, SGPT, serum bilirubin and alkaline phosphatase were estimated to assess liver function. These biochemical observations were supplemented by histopatllalogical examination of liver sections. The activity of extract was also comparable to Neutrosec a known hepatoprotective formulation.
Antihepatotoxic Activity of Cassia tora Leaf Extract
Tapan K. Maity,Subhash C. Mandal,M. Pal,B. P. Saha 한국생약학회 1998 Natural Product Sciences Vol.4 No.4
Methanolic extract of Cassia tora leaves was evaluated for its hepatoprotective activity in rats by inducing hepatotoxicity with paracetamol (acute model). The extract at a dose of 400 ㎎/㎏ orally exhibited significant protective effect by lowering the serum levels of transaminase (SGOT and SGPT), bilirubin, and alkaline phosphatase (ALP). The effects produced were comparable to that of a standard hepatoprotective agent.