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Inflammation Enhanced X-irradiation-Induced Colonic Tumorigenesis in the Min mouse
Nojiri, Ayumi,Toyoda, Takeshi,Tanaka, Takuji,Yoshida, Toshimichi,Tatematsu, Masae,Tsukamoto, Tetsuya Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.7
Inflammation is potential risk factor of various human malignancies. Inflammatory bowel syndromes such as ulcerative colitis are well known as risk factors for colon cancer. Here, we examined enhancing effects of dextran sulfate sodium (DSS)-associated inflammation on X-irradiation induced colonic tumorigenesis in Min and wild-type (WT) mice. Animals were X-irradiated at 1.5 Gy at 5 weeks of age (at 0 experimental week) and 2% DSS in drinking water was administered at 5 or 11 experimental weeks. Mice were sacrificed at 16 weeks and incidence and multiplicity of colonic tumors were assessed. Incidence of colonic tumors in Min mouse was increased from 33.3% to 100% (p<0.05) with X-irradiation alone, whereas no tumors were developed in WT mice. In DSS-treated Min mice, X-irradiation increased the number of colonic tumors. Total number of colonic tumors was increased 1.57 times to $30.7{\pm}3.83$ tumors/mouse with X-irradiation+DSS at 5 weeks comapared to $19.6{\pm}2.9$ in corresponding DSS alone group (p<0.05). When the duration of inflammation was compared, longer period of DSS effect promoted more colonic tumorigenesis. Collectively, we conclude that X-irradiation and DSS-induced inflammation act synergistically for colonic tumorigenesis.
Atomic Force Microscopic Study of Chitinase Binding onto Chitin and Cellulose Surfaces
Kikkawa, Yoshihiro,Fukuda, Masato,Kimura, Tomoya,Kashiwada, Ayumi,Matsuda, Kiyomi,Kanesato, Masatoshi,Wada, Masahisa,Imanaka, Tadayuki,Tanaka, Takeshi American Chemical Society 2014 Biomacromolecules Vol.15 No.3
<P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/bomaf6/2014/bomaf6.2014.15.issue-3/bm500046f/production/images/medium/bm-2014-00046f_0004.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/bm500046f'>ACS Electronic Supporting Info</A></P>
A three-dimensional movie of structural changes in bacteriorhodopsin
Nango, Eriko,Royant, Antoine,Kubo, Minoru,Nakane, Takanori,Wickstrand, Cecilia,Kimura, Tetsunari,Tanaka, Tomoyuki,Tono, Kensuke,Song, Changyong,Tanaka, Rie,Arima, Toshi,Yamashita, Ayumi,Kobayashi, Jun American Association for the Advancement of Scienc 2016 Science Vol.354 No.6319
<P>Bacteriorhodopsin (bR) is a light-driven proton pump and a model membrane transport protein. We used time-resolved serial femtosecond crystallography at an x-ray free electron laser to visualize conformational changes in bR from nanoseconds to milliseconds following photoactivation. An initially twisted retinal chromophore displaces a conserved tryptophan residue of transmembrane helix F on the cytoplasmic side of the protein while dislodging a key water molecule on the extracellular side. The resulting cascade of structural changes throughout the protein shows how motions are choreographed as bR transports protons uphill against a transmembrane concentration gradient.</P>
양영남,Rana B. Safarova,박소연,Yasuhito Sakuraba,오민혁,Ismayil S. Zulfugarov,이신범,Ayumi Tanaka,백남천,이춘환 한국식물학회 2019 Journal of Plant Biology Vol.62 No.1
The stay-green mutant of Arabidopsis thaliana,ore10 forms stable light-harvesting complex II (LHCII)aggregates during dark-induced senescence, which showed asingle base deletion (G1351) in the coding region of thepheophytinase (PPH) gene. PPH specifically dephytylatesthe Mg-free chlorophyll (Chl) pigment pheophytin, yieldingpheophorbide. In both ore10 and pph-1 mutants, pheophytina accumulated due to the deficiency of PPH gene, but theamount was relatively smaller than that of degraded Chl, andmost of the pheophytin a was bound to the stable LHCIIforming aggregates with some other Chl-protein (CP)complexes. Comparison of Chl a/b ratios in thylakoids,aggregates, and LHCII indicated that the suppression of Chlb to Chl a conversion was stronger when Chl b reductasewas missing and weak when PPH is missing in the large Chlcatabolic complex, which allowed the partial degradation ofChl b. These results suggest that the PPH-dependent pathway isnot specific for LHCII, but common for all CP complexes,including LHCII. In PPH-deficient mutants, the degradationof LHCII was suppressed by the formation of aggregates,and some of the remaining CP complexes and pheophytin awere included in the aggregates. Non-included CP complexeswere degraded via an unknown mechanism.