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RISS 인기검색어
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- 저자 : Atsushi Kohno (검색결과 2 건)
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Synthesis and Magnetic Properties of DyMnO3 Nanoparticles in Mesoporous Silica
Takayuki Tajiri,Atsushi Kohno,Kenta Hamamoto,Yuhki Ando,Hiroyuki Deguchi,Masaki Mito 한국물리학회 2013 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.63 No.3
We synthesized nanoparticles of the perovskite manganite DyMnO3 in pores of mesoporous silicaSBA-15 and investigated their magnetic properties. X-ray diffraction patterns of the nanoparticlesindicated successful synthesis of the DyMnO3 nanoparticles with a particle size of about 10 nmin the pores of SBA-15. The temperature dependence of the DC magnetic susceptibility for theDyMnO3 nanoparticles exhibited a pronounced magnetic irreversibility between the field-coolingand the zero-field-cooling susceptibility due to the blocking phenomena and indicated a change ofthe magnetic exchange interactions from those for the bulk crystal. The in-phase susceptibility χ" and the out-of-phase susceptibility χ" of the AC susceptibility for the nanoparticles exhibited apeak at the blocking temperature, and that peak shifted toward higher temperature with increasingfrequency. Magnetization curves for the nanoparticles were reproduced by using a Langevin functionand exhibited a hysteresis loop at temperatures below the blocking temperature. Magnetic sizeeffects and superparamagnetic behaviors were observed in the DyMnO3 nanoparticles.
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Tumor necrosis factor-α converting enzyme is a key mediator of abdominal aortic aneurysm development
Kaneko, Hidehiro,Anzai, Toshihisa,Horiuchi, Keisuke,Kohno, Takashi,Nagai, Toshiyuki,Anzai, Atsushi,Takahashi, Toshiyuki,Sasaki, Aya,Shimoda, Masayuki,Maekawa, Yuichiro,Shimizu, Hideyuki,Yoshikawa, Tsu Elsevier 2011 Atherosclerosis Vol.218 No.2
<P><B>Abstract</B></P><P><B>Objective</B></P><P>Tumor necrosis factor (TNF)-α is known to be elevated in plasma and the aorta in abdominal aortic aneurysm (AAA) patients. We sought to clarify the role of TNF-α converting enzyme (Tace), which cleaves the transmembrane precursor of TNF-α, in AAA development.</P><P><B>Methods</B></P><P>We obtained aortic sample of AAA during surgical operation to assess the histological features and protein expression of human AAA. AAA was induced in mice with temporal systemic deletion of Tace by the inducible Mx-1 Cre transgene (TaceMx1) and in wild-type littermates (CON) by periaortic application of CaCl<SUB>2</SUB> (AAA/TaceMx1, AAA/CON).</P><P><B>Results</B></P><P>Tace expression was increased in human AAA samples as compared with normal aorta. Six weeks postoperatively, aortic diameter in AAA/TaceMx1 was decreased than in AAA/CON in association with attenuated TNF-α expression and extracellular matrix disruption. Increased activities of matrix metalloproteinase (MMP)-9 and MMP-2, numbers of Mac-2-positive macrophages, CD3-positive T lymphocytes and CD31-positive vessels in periaortic tissues, mRNA expression of CD68, monocyte chemotactic protein-1, TNF-α, vascular endothelial growth factor-A, p47 and glutathione peroxidases, and protein expression of phospho-c-Jun N-terminal kinase in AAA were all attenuated by Tace deletion. Protein expression of transforming growth factor (TGF)-β1 was upregulated by Tace deletion in sham-operated mice. TGF-β1 expression was further increased in AAA/TaceMx1.</P><P><B>Conclusions</B></P><P>Tace was overexpressed in the aortic wall in human and experimental AAA. Temporal systemic deletion of Tace prevented AAA development in association with attenuating inflammation, oxidative stress, neoangiogenesis and extracellular matrix disruption, suggesting a crucial role of Tace in AAA development.</P>
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