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( Ashok Kumar Gupta ),( Shyam Sunder Pandey ),( Bajrangprasad Laxminarayan Pandey ) 대한피부과학회 2013 Annals of Dermatology Vol.25 No.2
Evidence for superior outcome by adhering to therapy guidelines is imperative to their acceptance and adaptation for the optimal management of disease variants. Objective: Comparative study of prospective outcomes in simultaneous consideration of independent variables in groups of 150 patients of plaque psoriasis either treated adhering to or in digression of standard guidelines. Methods: The psoriasis area severity index (PASI) and the dermatology life quality index (DLQI), prior to and after three months of uninterrupted therapy were examined in treatment groups among 150 patients. Recovery rates of 75% or more in PASI were compared. Independent variables were also examined for their bearing on the outcome. Results: The vast majority was early onset disease phenotype. All three treatment regimens when administered in adherence to the guidelines yielded significantly superior rates of defined recovery both in PASI and DLQI. Compromise of the therapeutic outcome appeared in high stress profiles, obesity, female sex and alcohol, tobacco or smoking habit. Conclusion: Conventional drug therapy of plaque psoriasis yields superior outcome by adhering to the consensus guidelines. Psychiatric address to stress must be integral and special considerations for phenotypic/syndromic variants is emphasized for effective therapy of psoriasis.
Shyam Kumar,Ashok Khanna 한국화학공학회 2014 Korean Journal of Chemical Engineering Vol.31 No.11
The effect of liquid and gas velocities, solid concentrations, and operating pressure has been studied ex-perimentally in a 15 cm diameter air-water-glass beads bubble column. The superficial gas and liquid velocities variedfrom 1.0 to 40.00 cm/s and 0 to 16.04 cm/s, respectively, while the solid loading varied from 1 to 9%. The gas holdupin the column was reduced sharply as we switched from batch to co-current mode of operation. At low gas velocity,the effect of liquid velocity was insignificant; while at high gas velocity, increasing liquid velocity decreased the gasholdup. Drift flux approach was applied to quantify the combined effect of liquid and gas velocities over gas holdup. For co-current three phase flows, the gas holdup decreased with increase in solid loading for all pressures. But for batchoperations, when solid loading was 5% or more, settling started leading to higher gas holdup. Increasing pressure fromatmospheric conditions increased the gas holdup significantly, flattening asymptotically.
Shailesh Ramakant Hadgaonkar,Ashok Kumar Shyam,Kunal Chandrakant Shah,Ketan Shripad Khurjekar,Parag Kantilal Sancheti 대한척추외과학회 2014 Asian Spine Journal Vol.8 No.5
Osteoblastomas are bone forming lesions arising mainly from posterior elements of the vertebra. They are commonly encountered in the cervical and lumbar regions. We present a case of a thoracic osteoblastoma which is extra osseous and is not communicating with any part of the vertebra present intraforaminally. This is a rare presentation of an osteoblastoma. Imaging studies do not accurately diagnose the osteiod lesion. The size of the lesion and cortical erosion seen on the computed tomography scan help in differentiating the osteoid osteoma and osteoblastoma, but they are less sensitive and specific. Thus a histopathology is the investigation of choice to diagnose the osteoblastoma. Early and adequate removal of mass prevents malignant transformation, metastasis, and recurrence. In our case we excised the pars interarticularis unilaterally, removed the osteoid mass intact, and performed unilateral instrumented fusion. There was no recurrence and solid fusion was seen at 3 years follow up.
Chaitanya Baban Chikhale,Ketan Shripad Khurjekar,Ashok Kumar Shyam,Parag Kantilal Sancheti 대한척추외과학회 2017 Asian Spine Journal Vol.11 No.2
Study Design: This was a single surgeon, single center-based retrospective study with prospective data collection. Purpose: To assess the correlation between T2-weighted magnetic resonance imaging (MRI) signal intensity (SI) changes and factors such as age, duration of symptoms, baseline modified Japanese Orthopedic Association (mJOA) score and to determine its prognostic value in predicting recovery after surgery. Overview of Literature: Whether intramedullary cord T2-weighted MRI SI changes can predict operative outcomes of cervical myeloradiculopathy remains debatable, with only a few prospective studies analyzing the same. Methods: Forty-six consecutive patients who underwent cervical myeloradiculopathy were included and were followed up for an average of 1 year. Preoperative T2-weighted MRI SI grading was performed for all patients. The correlation between MRI SI changes and age, duration of symptoms, preoperative mJOA score, and mJOA score at 1-year follow-up were analyzed. Results: Fifteen patients had single-level (21.73%) or double-level (10.86%) prolapsed discs; 54.34% had degenerative cervical spondylosis with canal stenosis or multilevel disc prolapse and 13.07% had ossified posterior longitudinal ligaments. The mean age was 56.17±9.53 years (range, 35–81 years). The mean baseline mJOA score was 10.83±2.58 (range, 6–16), which postoperatively improved to 13.59±2.28 (range, 8–17; p <0.001). There was a statistically significant correlation between mJOA score at 1 year and MRI T2 SI grading (p =0.017). Conclusions: Patients with longer symptom durations had high grades of intramedullary cord T2-weighted MRI SI changes. Age and preoperative neurological status were not significantly correlated with the existence of intramedullary cord SI changes. However, patients without or with mild and diffuse intramedullary cord T2-weighted MRI SI changes had better postoperative neurological recovery than those with sharp and focal SI changes.