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RISS 인기검색어
- 검색키워드
- 저자 : Ashish Patra (검색결과 4 건)
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( Ashish Kumar Vyas ),( Sharda Patra ),( Archana Rastogi ),( Shiv Ku-mar Sarin ),( Nirupma Trehanpati ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: Vertical transmission of Hepatitis B virus (HBV) from infect ed mother to the newborn is the major cause of HBV chronicity. Asialoglycoprotein receptor (ASGPR) expression on hepatocytes has been associated with HBV entry and endocytosis. However, there is a big lacuna regarding expression of ASGPR expression on placental cells and its role in HBV vertical transmission. Methods: 34 HBsAg+ve and 13 healthy pregnant mothers were enrolled along with their newborns. QHBsAg, HBV DNA and liv er-function-test were performed among the groups. HBsAg+ve women were grouped into transmitting and non-transmitting mothers on the basis of newborns HBsAg and HBVDNA. Ex pression of ASGPR and HBsAg were analyzed in placental tissue using Immunohistochemistry and immunofluorescence staining. Peripheral and cord blood-mononuclear cell together with den dritic cells (mDCs and pDCs) were analyzed for the expression of DC-ASGPR, using flow cytometry and QPCR in all subjects. Results: The incidence of HBV vertical transmission to the newborn was 18% among the HBsAg positive pregnant fe males. HBV transmitting mothers showed increased expression of ASGPR in trophoblasts of placenta. Immunofluorescence microscopy revealed co-localization of HBsAg and ASGPR in placenta as well as in DCs of HBV transmitting mothers. HBV transmitting mothers and their HBsAg+ve newborns showed increased mRNA levels of DC-ASGPR in PBMCS. However, flow cytometry revealed no significant difference in the expression of ASGPR on PBMCs or CBMCs cells between the 2 groups. The HBV transmitting mothers and their HBsAg+ve newborns also showed an increased expression of DC-ASGPR on both myeloid and plasmocytoid dendritic cells compared to HBV non-trans mitting mothers and their HBsAg negative newborns. Conclusions: The present work highlights for the first time a role of ASGPR in the intrauterine mother to baby HBV transmis sion. Blocking of ASGPR appears to be novel therapeutic strate gy for prevention of HBV mother to baby vertical transmission.
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Chiranjib Chakraborty,Ashish Ranjan Sharma,Sharma Garima,Manojit Bhattacharya,Bidhan C. Patra,Bimal Kumar Sarkar,Saptarshi Banerjee,Kankana Banerjee,Sang‑Soo Lee 한국유전학회 2021 Genes & Genomics Vol.43 No.7
Background Currently, Tigers (the top predator of an ecosystem) are on the list of endangered species. Thus the need is to understand the tiger’s population genomics to design their conservation strategies. Objective We analyzed the molecular evolution of tiger diversity using NADH dehydrogenase subunit 4 (ND4), a signifcant electron transport chain component. Methods We have analyzed nucleotide composition and distribution pattern of ND genes, molecular evolution, evolutionary conservation pattern and conserved blocks of NADH, phylogenomics of ND4, and estimating species divergence, etc., using diferent bioinformatics tools and software, and MATLAB programming and computing environment. Results The nucleotide composition and distribution pattern of ND genes in the tiger genome demonstrated an increase in the number of adenine (A) and a lower trend of A+T content in some place of the distribution analysis. However, the observed distributions were not signifcant (P > 0.05). Evolutionary conservation analysis showed three highly align blocks (186 to 198, 406 to 416, and 527 to 545). On mapping the molecular evolution of ND4 among model species (n = 30), we observed its presence in a broader range of species. ND4 based molecular evolution of tiger diversity and time divergence for a tiger (20 diferent other species) shows that genus Panthera originated more or less at a similar time. Conclusions The nucleotide composition and nucleotide distribution pattern of tiger ND genes showed the evolutionary pattern and origin of tiger and Panthera lineage concerning the molecular clock, which will help to understand their adaptive evolution.
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Pole Placement Using Genetic Algorithm with Integral Control
Abhishek Pratap Singh,Ashish Patra 보안공학연구지원센터 2015 International Journal of u- and e- Service, Scienc Vol.8 No.6
This paper presents the application of genetic algorithms to find the optimum feedback gains in pole placement with integral control to get the desired performance in control system. Performances are measured in terms of key parameters like settling time, peak overshoot, undershoot, rise time etc in control system. The major drawbacks of pole placement technique are to get optimum location of poles and we cannot place zeros at desired locations. Dominating concept of poles is enough for placing poles for systems which transfer functions are without zeros. But if there are zeros in transfer function then it is not enough to place pole with dominating pole concept because presence of zero can destroy the dynamic response of control system. In this paper genetic algorithm is used to find the optimum locations of poles to get the desired response and compensate the effect of zeros on transient in case zeros are present in transfer function. GA is a population based algorithm to find the global solution of a problem. This paper compares the unit step response of a plant with presence of zero in transfer function. The same GA based technique is used for finding optimum location of poles to get the desired response for magnetic levitation system. This analysis is well supported by the simulation and experimental results done using MATLAB and Simulink.
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DNA barcoding to fishes: current status and future directions
Bhattacharya, Manojit,Sharma, Ashish Ranjan,Patra, Bidhan Chandra,Sharma, Garima,Seo, Eun-Min,Nam, Ju-Suk,Chakraborty, Chiranjib,Lee, Sang-Soo Informa UK (Informa Healthcare) 2016 Mitochondrial DNA. Part A Vol.27 No.4
<P>DNA barcoding appears to be a promising approach for taxonomic identification, characterization, and discovery of newer species, facilitating biodiversity studies. It helps researchers to appreciate genetic and evolutionary associations by collection of molecular, morphological, and distributional data. Fish DNA barcoding, based on the sequencing of a uniform area of Cytochrome C Oxidase type I (COI) gene, has received significant interest as an accurate tool for species identification, authentication, and phylogenetic analysis. The aim of this review article was to investigate recent global status, approaches, and future direction of DNA barcoding in fisheries sectors. We have tried to highlight its possible impacts, complications, and validation issues at species levels for biodiversity analysis. Moreover, an effort has been put forward to understand issues related to various marker genes associated with barcode process as primer sequences and have concluded barcode promotion as an indispensable tool of molecular biology for the development of taxonomic support systems.</P>
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