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        Modified Endoscopic Ultrasound Needle to Obtain Histological Core Tissue Samples: A Retrospective Analysis

        Munish Ashat,Kaartik Soota,Jagpal S. Klair,Sarika Gupta,Chris Jensen,Arvind R. Murali,Randhir Jesudoss,Rami El Abiad,Henning Gerke 대한소화기내시경학회 2020 Clinical Endoscopy Vol.53 No.4

        Background/Aims: Endoscopic ultrasound (EUS)-guided fine-needle aspiration is very effective for providing specimens forcytological evaluation. However, the ability to provide sufficient tissue for histological evaluation has been challenging due to thetechnical limitations of dedicated core biopsy needles. Recently, a modified EUS needle has been introduced to obtain tissue coresamples for histological analysis. We aimed to determine (1) its ability to obtain specimens for histological assessment and (2) thediagnostic accuracy of EUS-guided fine-needle biopsy (EUS-FNB) using this needle. Methods: We retrospectively analyzed consecutive cases of FNB using modified EUS needles for 342 lesions in 303 patients. Thecytology and histological specimens were analyzed. Diagnostic accuracy was calculated. Results: Adequate cytological and histological assessment was possible in 293/342 (86%) and 264/342 (77%) lesions, respectively. Diagnostic accuracy of the cytological specimen was 294/342 (86%) versus 254/342 (74%) for the histological specimen (p<0.01). Diagnostic accuracy of the combined cytological and histological assessment was 323/342 (94.4%), which was significantly higher thanthat of both histology alone (p<0.001) and cytology alone (p=0.001). Conclusions: EUS-FNB with the modified EUS needle provided histologic tissue cores in the majority of cases and achieved excellentdiagnostic accuracy with few needle passes.

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