General nonlocal solution of the elastic half space loaded by a concentrated force P perpendicular to the boundary

Artan, R. Techno-Press 2000 Structural Engineering and Mechanics, An Int'l Jou Vol.9 No.2

The main purpose of this paper is to develop the results introduced in Artan (1996) and to find a general nonlocal linear elastic solution for Boussinesq problem. The general nonlocal solution given Artan (1996) is valid only when the distance to the boundary is greater than one atomic measure. The nonlocal stress field presented in this paper is valid for the whole half plane.

Food-derived sensory cues modulate longevity via distinct neuroendocrine insulin-like peptides

Artan, Murat,Jeong, Dae-Eun,Lee, Dongyeop,Kim, Young-Il,Son, Heehwa G.,Husain, Zahabiya,Kim, Jinmahn,Altintas, Ozlem,Kim, Kyuhyung,Alcedo, Joy,Lee, Seung-Jae V. Cold Spring Harbor Laboratory Press 2016 Genes & development Vol.30 No.9

<P>Environmental fluctuations influence organismal aging by affecting various regulatory systems. One such system involves sensory neurons, which affect life span in many species. However, how sensory neurons coordinate organismal aging in response to changes in environmental signals remains elusive. Here, we found that a subset of sensory neurons shortens Caenorhabditis elegans' life span by differentially regulating the expression of a specific insulin-like peptide (ILP), INS-6. Notably, treatment with food-derived cues or optogenetic activation of sensory neurons significantly increases ins-6 expression and decreases life span. INS-6 in turn relays the longevity signals to nonneuronal tissues by decreasing the activity of the transcription factor DAF-16/FOXO. Together, our study delineates a mechanism through which environmental sensory cues regulate aging rates by modulating the activities of specific sensory neurons and ILPs.</P>

Heat FLiPs a Hormonal Switch for Longevity

Artan, M.,An, Seon Woo A.,Lee, S.Jae V. Cell Press 2016 DEVELOPMENTAL CELL Vol.39 No.2

<P>Temperature-sensing neurons in C. elegans reduce the life-shortening effects of high temperatures via steroid signaling. In this issue of Developmental Cell, Chen et al. (2016) elucidate the underlying mechanisms by which the transcription factor CREB induces the neuropeptide FLP-6 in the temperature-sensing neurons to counteract the life-shortening effects of high temperature.</P>

[P8-285] Inhibitory effect of sulfated chitooligosaccharides on HIV-1 infection

Murat Artan,Fatih Karademz,Moon-Moo Kim,Se-Kwon Kim 한국식품영양과학회 2008 한국식품영양과학회 학술대회발표집 Vol.2008 No.10

Gastritis Associated with Initially Pediatric Crohn's Disease and Ulcerative Colitis

Basturk, Ahmet,Artan, Reha,Yilmaz, Aygen,Gelen, Mustafa T. The Korean Society of Pediatric Gastroenterology 2018 Pediatric gastroenterology, hepatology & nutrition Vol.21 No.3

Purpose: The aim of this study is to determine the involvement of the upper gastrointestinal system (GIS) in patients diagnosed with Crohn's disease (CD), ulcerative colitis (UC), and non-inflammatory bowel disease (IBD) and to compare their differences. Methods: This study included patients aged between 2 and 18 years who underwent colonoscopy and esophagogastroduodenoscopy (EGD) for the first time due to the prediagnosis of IBD. In EGD, samples were taken from duodenum, antrum, corpus, and esophagus; and gastritis, duodenitis, and esophagitis were identified through histopathologic examination. The data gathered the ends of the research were compared between IBD with non-IBD groups and between CD-UC with non-IBD groups, and the presence of significant differences between groups were determined. Results: In our study, 16 patients were diagnosed with CD, 13 with UC, 3 with undeterminate colitis, and 13 with non-IBD. In the histopathological examination of the groups, GIS involvement was found in 94.1% of patients diagnosed with IBD and in 38.5% of non-IBD patients. Moreover, the difference was found to be statistically significant (p=0.032). No significant difference was found between the CD and UC groups. Gastritis was mostly observed in 93.8% of CD-diagnosed patients, 76.8% of UC-diagnosed patients, 81.2% of IBD-diagnosed patients, and 38.5% of non-IBD-diagnosed patients. On the other hand, significant differences were found between CD and non-IBD groups (p=0.03), UC and non-IBD groups (p=0.047), and IBD and non-IBD groups (p=0.03). Conclusion: The results of the study show that gastritis was highly observed in UC- and CD-diagnosed patients than in non-IBD-diagnosed patients.

Inhibition of elongin C promotes longevity and protein homeostasis via HIF ‐1 in <i>C. elegans</i>

Hwang, Wooseon,Artan, Murat,Seo, Mihwa,Lee, Dongyeop,Nam, Hong Gil,Lee, Seung‐,Jae V. BLACKWELL PUBLISHING 2015 AGING CELL Vol.14 No.6

<P><B>Summary</B></P><P>The transcription factor hypoxia‐inducible factor 1 (HIF‐1) is crucial for responses to low oxygen and promotes longevity in <I>Caenorhabditis elegans</I>. We previously performed a genomewide RNA interference screen and identified many genes that act as potential negative regulators of HIF‐1. Here, we functionally characterized these genes and found several novel genes that affected lifespan. The worm ortholog of <I>elongin C</I>,<I> elc‐1</I>, encodes a subunit of E3 ligase and transcription elongation factor. We found that knockdown of <I>elc‐1</I> prolonged lifespan and delayed paralysis caused by impaired protein homeostasis. We further showed that <I>elc‐1 </I>RNA interference increased lifespan and protein homeostasis by upregulating HIF‐1. The roles of elongin C and HIF‐1 are well conserved in eukaryotes. Thus, our study may provide insights into the aging regulatory pathway consisting of elongin C and HIF‐1 in complex metazoans.</P>

Investigation of Efficacy of Lidocaine Spray for Sedated Esophagogastroduodenoscopy in Children

Basturk, Ahmet,Artan, Reha,Yilmaz, Aygen The Korean Society of Pediatric Gastroenterology 2017 Pediatric gastroenterology, hepatology & nutrition Vol.20 No.2

Purpose: Our aim in this study is to investigate efficacy of topical lidocaine spray for sedated esophagogastroduodenoscopy (EGD) in children. Methods: The endoscopy of children aged between 3-18 years who underwent EGD in our endoscopy unit. Intravenous (IV) midazolam and ketamine were used for sedation. Prior to sedation, endoscopy nurse applied topical lidocaine 10% with pump spray at 1 mg/kg dose in group 1, and distilled water via identically scaled pump spray in group 2, in a double blinded fashion. Results: Sedation was not applied in 24.1% of the cases in topical lidocaine spray group (LS group) and in 5.7% of the cases in distilled water spray group (DS group). Gag reflex was observed in 6.5% of cases in LS group and 33.3% of cases in DS group (p=0.024), increased oral secretion was observed in 9.3% of cases in LS group and 51.7% of cases in DS group (p=0.038), sore throat was observed in 3.7% of cases in LS group and 35.6% of cases in DS group (p=0.019) and the difference was statistically significant. Conclusion: The study showed that topical pharyngeal lidocaine reduces both requirement and amount of IV sedation before EGD in children and sore throat, gag reflex and decreased oral secretion increase.

Turkish Adaptation of Integrated Creativity Test-Preschooler- ICT-P: A Validity and Reliability Study

Binhan Koyuncuoğlu,İsmihan Artan 숭실대학교 영재교육연구소 2019 Global Creative Leader Vol.9 No.6

The aim of the study is to investigate the psychometric characteristics of the “Integrated Creativity Test-Preschooler-ICT-P” (Creative Thinking Ability Domain) for Turkish children. The study included 104 Turkish children aged 4-5 from Sinop city center. The ICT-P (Creative Thinking Ability Section) has language and drawing sub-domains. The language domain consists of imagination, fluency, flexibility and originality factors. The drawing domain consists of continuation & connection, completion, new elements addition, theme, and unconventionality factors. The translation and back translation processes were conducted for the Turkish adaptation of the scale. Expert opinions were obtained for scope, semantic and conceptual equivalence. The validity and reliability analyzes were conducted to determine that the test was successful in fulfilling certain objectives related to the characteristics that fit wanted to measure. For the reliability assessment: To predict the stability of the test, Test-Retest Reliability and Pearson Moments Multiplication Correlation Coefficient were evaluated. For observer reliability, intra-observer consistency and the inter-measure consistency percentage were utilized. For internal consistency Cronbach's alpha reliability coefficient was calculated. For determining the validity of the test, content validity with expert opinions and construct validity with factor analysis were tested. Exploratory Factor Analysis projected that the scale has a two factor structure composed of 11 sub factors. Results of CFA clarified that the scale has a two factor structure. Inner consistency coefficients and test-retest values proved that the test is a reliable measurement tool. The results of the study confirmed that the test can be used in the assessment of the creative thinking ability of 4-5 year-old Turkish children.

Effects of nutritional components on aging

Lee, Dongyeop,Hwang, Wooseon,Artan, Murat,Jeong, Dae-Eun,Lee, Seung-Jae BLACKWELL PUBLISHING 2015 AGING CELL Vol.14 No.1

<P>Nutrients including carbohydrates, proteins, lipids, vitamins, and minerals regulate various physiological processes and are essential for the survival of organisms. Reduced overall caloric intake delays aging in various organisms. However, the role of each nutritional component in the regulation of lifespan is not well established. In this review, we describe recent studies focused on the regulatory role of each type of nutrient in aging. Moreover, we will discuss how the amount or composition of each nutritional component may influence longevity or health in humans.</P>

Role of Soluble Adiponectin Receptor 2 in Non-Alcoholic Fatty Liver Disease in Children

Aksoy, Gulsah Kaya,Artan, Reha,Aksoy, Cihat,Ozdem, Sebahat,Atalay, Atike,Yilmaz, Aygen The Korean Society of Pediatric Gastroenterology 2019 Pediatric gastroenterology, hepatology & nutrition Vol.22 No.5

Purpose: The incidence of non-alcoholic fatty liver disease (NAFLD) in children is gradually increasing. The aim of this study was to investigate the use of serum adiponectin and soluble adiponectin receptor 2 (soluble Adipo R2) levels for the diagnosis of fatty liver disease in obese and overweight children. Methods: The study included 51 obese and overweight children between the ages of 6 and 18 years diagnosed with NAFLD using ultrasonography and 20 children without fatty liver disease. Patients whose alanine transaminase level was two times higher than normal (${\geq}80U/L$) were included in the non-alcoholic steatohepatitis (NASH) group. Results: NASH was observed in 11 (21.6%) of the patients with NAFLD. The incidence of obesity was higher in patients with NASH (80% and 45%, p=0.021). While the adiponectin levels were similar in patients with NAFLD and those without, they were below the normal level in the whole study group. Adiponectin and soluble Adipo R2 levels of patients with NASH were lower than those in patients without NASH; however, this difference was not statistically significant (p=0.064 and p=0.463). Soluble Adipo R2 levels in obese patients with NAFLD were higher than those in obese children without NAFLD (p<0.001). Conclusion: Soluble adiponectin receptor 2 level is a noninvasive marker that can be used for the diagnosis of NAFLD in obese children.