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- 저자 : Arindam Ghosh (검색결과 4 건)
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Dipankar Ghosh,Arindam Pramanik,Narattam Sikdar,Panchanan Pramanik 한국생물공학회 2011 Biotechnology and Bioprocess Engineering Vol.16 No.2
The purpose of this study was to prepare low molecular weight alginic acid (LMWA) nanoparticles by cation-induced, controlled gelification of depolymerized alginic acid for effective drug delivery to drug resistant bacteria. The depolymerization reaction was performed using potassium persulfate oxidation at an optimized condition. The optimized conditions for depolymerization were anticipated to be 37℃, pH 4, 2 days reaction time, and a 0.075 M concentration of potassium persulphate containing 0.001 M silver nitrate in the final reaction mixture. Gel permeation chromatography showed depolymerized alginic acid had an average molecular weight of 20.95 ± 0.49 kDa. Depolymerized alginic acid was also characterized for its structural integrity by X-ray diffraction, nuclear magnetic resonance, and Fourier transform spectroscopy. Depolymerized alginic acid was used to prepare low molecular weight nanoparticles with a particle size of 54 ± 0.41 nm,and a zetapotential of −32.2 ± 3.91 mV. The nanoparicles were then subjected to tetracycline loading. In vitro drug loading and drug release efficiencies after 100 h were determined to be 66.56 ± 1.88 and 61.8 ±0.141%, respectively. Finally, the minimal inhibitory concentration and a putative mode of action for the tetracycline nanoparticles were determined using tetracycline resistant bacteria,Escherichia coli XL-1.
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Metabolomics affirms traditional alcoholic beverage raksi as a remedy for high-altitude sickness
Soumya Majumder,Arindam Ghosh,Sourav Chakraborty,Sumedha Saha,Malay Bhattacharya 한국식품연구원 2021 Journal of Ethnic Foods Vol.8 No.-
Raksi, a fermented distilled alcoholic beverage, is an ethnic drink consumed in high altitude regions of Singalila Ridge of the Himalayas and in adjoining high altitude places in Nepal, northern and north eastern part of India and Tibetan plateau. Like jaanr, tongba, nigar, chhyang, and other fermented ethnic beverages, raksi is considered as an element of ethnopharmacology of high altitude with claims of medicinal properties. An ethnobiological survey was done in the study area prior to collection and identification of raksi samples. In this research, two raksi samples (khokim raksi and chimphing raksi) of Singalila Ridge of the Himalayas were investigated by metabolite profiling using gas chromatography-mass spectrometry analysis. Results of the experiment showed presence of several respiratory protective, cardioprotective, neuroprotective, anti-inflammatory, and antioxidant components which have properties to prevent various high altitude illnesses. Moreover, large quantities of bioactive terpenoids, fatty acid derivatives, coumarins, and peptides were detected whose chemotaxonomy and biosynthesis pathways were further studied. This metabolomics investigation not only affirmed Raksi as a remedy for high-altitude sickness but also helped in understanding the importance of this type of ethnic foods in high altitude ethnoecology. This research on raksi in the fields of ethnobiology and metabolomics is a cumulative approach which has opened the door for in-depth investigations on similar ethnic foods. However, further experiments on raksi are surely needed in ethnobiology, microbiology, biochemistry, and food technology.
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Interconnection of Two Neighboring Autonomous Microgrids Based on Small Signal Analysis
Ehsan Pashajavid,Farhad Shahnia,Arindam Ghosh 전력전자학회 2015 ICPE(ISPE)논문집 Vol.2015 No.6
Load-shedding is a mechanism to prevent overloading of an islanded microgrid (MG). To minimize load-shedding, extra support can be provided by interconnecting the overloaded MG to another islanded neighboring MG to support each other. For this, extra generation capacity needs to be available in the distributed energy resources of the neighboring MG. This paper proposes a decision making criterion for interconnection of two neighboring islanded MGs based on small signal stability analysis. The closed-loop control system of an MG is expressed in statespace domain and used for the stability analysis of the individual MGs as well as the system of coupled MGs. The results of this analysis are applied as a stability criterion to allow interconnection of two islanded MGs. Additionally, if it is revealed that interconnection of MGs will cause instability, the analysis yields the proper range for the droop control coefficients which need to be updated in the DERs, before they MGs are interconnected. MATLAB-based simulation studies are provided to evaluate the developed small signal stability analysis.
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Bicyclic Baird-type aromaticity
Cha, Won-Young,Kim, Taeyeon,Ghosh, Arindam,Zhang, Zhan,Ke, Xian-Sheng,Ali, Rashid,Lynch, Vincent M.,Jung, Jieun,Kim, Woojae,Lee, Sangsu,Fukuzumi, Shunichi,Park, Jung Su,Sessler, Jonathan L.,Chandrashe Nature Publishing Group 2017 Nature chemistry Vol.9 No.12
Classic formulations of aromaticity have long been associated with topologically planar conjugated macrocyclic systems. The theoretical possibility of so-called bicycloaromaticity was noted early on. However, it has yet to be demonstrated by experiment in a simple synthetic organic molecule. Conjugated organic systems are attractive for studying the effect of structure on electronic features. This is because, in principle, they can be modified readily through dedicated synthesis. As such, they can provide useful frameworks for testing by experiment with fundamental insights provided by theory. Here we detail the synthesis and characterization of two purely organic non-planar dithienothiophene-bridged [34]octaphyrins that permit access to two different aromatic forms as a function of the oxidation state. In their neutral forms, these congeneric systems contain competing 26 and 34 π-electronic circuits. When subject to two-electron oxidation, electronically mixed [4n+1]/[4n+1] triplet biradical species in the ground state are obtained that display global aromaticity in accord with Baird's rule.
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