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Marycruz Barocio-Pantoja,Patricia Quezada-Fernández,David Cardona-Muller,Mayra B Jiménez-Cázarez,Mariana Larios-Cárdenas,Oscar I. González-Radillo,Andrés García-Sánchez,Jaime Carmona-Huerta,Ana N. Chá 한국식품영양과학회 2021 Journal of medicinal food Vol.24 No.12
One of the proposed mechanisms for the development of diabetic nephropathy (DN) is the increase of end products of advanced glycosylation (AGEs), which bind to its receptor (RAGE), favoring nephron cellular damage. An isoform of this receptor is soluble RAGE (sRAGE), which can antagonize AGE-altered intracellular signaling. It has known that green tea extract (GTE) increases the expression of sRAGE, but it is unknown whether this could improve kidney function. The objective of this study was to evaluate the effect of the administration of GTE on the concentrations of sRAGE, renal function, and metabolic profile in patients with type 2 diabetes mellitus (T2DM) and DN. A randomized, double-blinded, placebo-controlled clinical trial was carried out in 39 patients who received GTE (400 mg every 12 h) or placebo for 3 months. sRAGE levels, renal function, and metabolic parameters were determined before and after the intervention. In the GTE group, there were statistically significant increase on sRAGE (320.55 ± 157.63 pg/mL vs. 357.59 ± 144.99 pg/mL; P = .04) and glomerular filtration rate (GFR; 66.44 ± 15.17 mL/min/1.73 m2 vs. 71.70 ± 19.33 mL/min/1.73 m2; P = .04), and a statistically significant decrease in fasting serum glucose (7.62 ± 3.00 mmol/L vs. 5.86 ± 1.36 mmol/L; P ≤ .01) and triacylglycerols (1.91 ± 0.76 mmol/L vs. 1.58 ± 0.69; P = .02). Administration of GTE increases the serum concentration of sRAGE and the GFR and decreases the concentration of fasting serum glucose and triacylglycerols. The study was registered in ClinicalTrials.gov with the identifier NCT03622762.
Control of 3-Phase 4-Wire Isolated Grids
Jurgen Buttner,Thomas Ellinger,Andre Muller,Jurgen Petzoldt 전력전자학회 2001 ICPE(ISPE)논문집 Vol.2001 No.10
The generation of isolated grids by pulsed converters with characteristics close to the mains of the utility companies is a pretentious task. For generation of three-phase four-wire isolated grids are presented possible topologies and the demands on the system control are processed. For control of all conceivable load and error conditions, an extensive control technology is necessary. This must permit unsymmetrical operating conditions for an unlimited period but recognize errors simultaneously and therefore an overloading the consumer and the power semiconductors reliable may prevent. Measurement results on an experimental plant show the problems to be solved.
Alrwashdeh, Saad S.,Markotter, Henning,Haussmann, Jan,Hilger, Andre,Klages, Merle,Muller, Bernd R.,Kupsch, Andreas,Riesemeier, Heinrich,Scholta, Joachim,Manke, Ingo Korean Society of Microscopy 2017 Applied microscopy Vol.47 No.3
In this investigation, synchrotron X-ray imaging was used to investigate the water distribution inside newly developed gas diffusion media in polymer electrolyte membrane fuel cells. In-situ radiography was used to reveal the relationship between the structure of the microporous layer (MPL) and the water flow in a newly developed MPL equipped with randomly arranged holes. A strong influence of these holes on the overall water transport was found. This contribution provides a brief overview to some of our recent activities on this research field.